1.Ombitasvir/paritaprevir/ritonavir+dasabuvir and ribavirin associated drug-induced liver injury and syndrome of inappropriate secretion of anti-diuretic hormone: A case report
Rahul KUMAR ; John Chen HSIANG ; Jessica TAN ; Prem Harichander THURAIRAJAH
Clinical and Molecular Hepatology 2019;25(3):326-330
No abstract available.
Drug-Induced Liver Injury
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Ribavirin
7.Panax Ginseng Induces Toxic Hepatitis and Acute Kidney Injury
Jeong Ho LEE ; Jung Hwan YOON ; Sung Sun KIM ; Seong Kwon MA ; Soo Wan KIM ; Eun Hui BAE
Chonnam Medical Journal 2017;53(2):168-169
No abstract available.
Acute Kidney Injury
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Drug-Induced Liver Injury
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Panax
9.Primary study on hepatoprotective effect of curcuminoid in mice
Thanh Ngoc Vu ; Mai Thi Tuyet Vu
Journal of Medical Research 2007;47(2):22-28
Background: Curcuminoid in crocus has a wide spectrum of therapeutic effects such as antitumor and anti-inflammatory effects, including antibacterial, antiviral, antifungal, and antispasmodic activities. Curcuminoid \ufffd?biofavonoid, a component of Cucuma longa L is attracting attention of researchers because of their effects and low toxicity. Objectives:To evaluate the hepatoprotective effect of curcuminoid on acute liver injury induced by carbon tetraclorid (CCl4 and paracetamol (PAR) in mice.) Subjects and method: Curcuminoid at doses of 60mg/kg and 120mg/kg were used in 8 consecutive days before hepatotoxins ( CCl4 0.5ml/kg in olive oil or PAR 400mg/kg) in mice.Results & Conclusion: Curcuminoid has hepatoprotective effect, expressed by reductions of serum levels of ALT, AST and liver histopathological injuries, in comparison with the control group ( which didn\u2019t use any drug). Curcuminoid at doses of 60mg/kg and 120mg/kg have hepatoprotective effect on acute liverinjury induced by carbon tetraclorid and paracetamol in mice. Curcuminoid at two different doses and silymarin at a dose 67mg/kg. The result showed that just low dose of curcuminoid (60mg/kg in mice) was enough to protect liver. It was just cheaper and safer than using high dose when using high dose the effect was not increase much.\r\n', u'\r\n', u'
Curcuma/ chemistry
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drug effects
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Drug-Induced Liver Injury
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