Cellulose was prepared successfully from rice straw by alkali and acid method and bleached by hydrogen peroxide. The effects of percentages of sodium hydroxide, hydrogen peroxide and bleaching method on quality of the cellulose were studied. The product meets requirements of the pharmaceutical grade and may be applied for producing tablets.
cellulose ; Drug Compounding

Microcrystalline cellulise was prepared successfully from cellulose was prepared successfully from cellulose of rice straw by selective hydrolytic method in dilute hydrochloride acid. Effects of percentages of hydrochloride acid, duration of hydrolysis process on productivity and coloration of the Microcrystalline cellulose collected were studied. The product was standardized and complied with it is standard. The product may be applied for producing tablets.
cellulose ; Drug Compounding

Bagasse, an abundant available waste has high -cellulose content (more than 38%) and less than 1.5% as content. In Vietnam, bagasse from refinery at VietTri, VanDiem has cellilose content more than 48%. Powdered cellulose, which is used as a tablet diluent, can be prepared from bagasse. Product is a white powder and loses less than 5.7% of its weight when dried. The supernatant liquid of a 10% dispersion in water has a pH of 7.02.
cellulose ; Drug Compounding

Purpose: Use experimental scheme to find some optimal conditions for reaction of acylized N-phtalyl chitosan stage. Material: green clawed shrimp shell. Preparing following modified water-heat method. Divide into 2 stages: Preparation N-phtalyl chitosan and soluble film created agent in the intestine in optimal conditions. Result: Derivative can be used to make a soluble film created agent in the intestine like CAP, HPMCP.
Chitosan ; Drug Compounding

Semi synthesis of a derivative of chitosan from shrimp shell, which is called Acetyl phtanyl chitosan. Material: green clawed shrimp, pure chemical. Preparation according to heat-water therapy including 2 stages; Preparation N-phtalyl chitosan and derivative of chitosan with property "film created substance dissolves intestine". Film have property which not dissolve in water, solution of HCl 0.1N, pH 1.3; but well dissolves in solution of phosphate pH6. This derivative can be used to make the film created substance that dissolved in intestine.
chitosan ; Drug Compounding

4-chloroanilline, 5-chlorosalicylanilid and 3,5-dichlorosalicylic acid are obtained by chlorination aniline and salicylic acid in difference conditions. Condensation of the above compounds with aniline, salicylic acid and each other to get chlorosalicylanilid derivatives. Chlorosalicylanilid derivatives have high antibiotic and antifungal activity. All most of chlorosalicylanilid derivatives has low toxicity.
Drug Compounding ; chemical synthesis

A titration in nonaqueous medium was proposed to determine simultaneously the mixtures of Chlorpheniramine maleat and the other halogen salts (Dextromethorphan HBr and phenylpropanilamin HCl). The first one was assayed for having the equivalent point EP1. For the second halogen salts we added (CH3COO)2 for liberating halogen radicaux and trans forming to base form. This form was recorded the equivalent point EP2.
Chlorpheniramine ; Drug Compounding

5 thiourea derivatives were synthesized by condensation of 4- chlorophenylisothiocyanat with p-aminobenzoic acide and its derivatives. Condensation of 4-chlorophenylisothiocyanat with phenylhydrazine derivatives to give 2 thiosemicarbazid derivatives. The structure of the obtained products was determined by elementary analysis and IR spectroscopy. The study indicated that all of them have effect on bacteria Gram (+) but this effect on Gram (-) bacteria was weaker. All most of them have effect on Microsporum gypseum and Tricophyton mentagrophytes. Two compounds have effect on candida albicans.
Drug Compounding ; Antifungal Agents ; Anti-Bacterial Agents

Condensation of 4-chlorophenylisocyanat with amine compounds (p-amino salicylic acide, phenyl hydrazine derivatives) gets 7 thiourea derivatives. The structures of the obtained products were determined by elemental analysis and IR spectroscopy. The study indicated that all of them have strong effect on bacteris Gram(+) but weak on GR(-). Six compounds have affected on Microsporum gypseum and Tricophyton mentagrophytes. Two compounds have effects on Candida albicans.
Antifungal Agents ; Anti-Bacterial Agents ; Drug Compounding

As an advanced concept in international pharmaceutical research,quality by design( QbD) can fulfill the strategic requirements of drug quality from testing to design. In this paper,the extraction process of Yanggong Prescription which was the modified Siwu Decoction was optimized based on QbD concept. With the extraction amount of solid matter,the content of ferulic acid and the content of paeoniflorin as critical quality attributes( CQAs),the failure mode and effect analysis( FMEA) was used to screen potential critical process parameters( p CPPs). The mathematical model was established by Box-Behnken experimental design to investigate the interaction between critical process parameters( CPPs) and CQAs. Then the design space for the extraction process of Yanggong Prescription was further established and optimized. Analysis of variance showed that the variance of all models was significant( P<0. 01),and the lack-of-fit value was not significant,indicating that the model was statistically significant. The relationship between various factors and the response values could be functionalized by the established models. Finally,through the optimization of the design space,the optimum extraction process of Yanggong Prescription was obtained as follows: 3 extraction times,122 minutes extraction,and 7 times of water adding. The extraction process of Yanggong Prescription based on the QbD concept was robust and reliable,which would provide guidance for the process development and quality control of its formulations.
Drug Compounding ; Quality Control ; Research Design ; Water