Objective To discuss the selection of operation methods of total hysterectomy in obese women. Methods We reviewed clinical data of 116 obese women with the body mass index (BMI) ≥ 28 kg/m~2 treated with total hysterectomy. According to the operative procedure, 56 women underwent the vaginal total hysterectomy (Vaginal Group) and 60 women, abdominal total hysterectomy (Abdominal Group). Intra- and post-operative records were compared between the two groups. Results As compared with the Abdominal Group, the Vaginal Group presented a significantly shorter operation time (t=-3.693,P=0.000) and hospital stay (t=-7.019, P=0.000), a significantly less intraoperative blood loss (t=-4.006,P=0.000), and a significantly lower postoperative pyrexia rate (?~2=4.388,P=0.036) and complication rate (?~2=5.243,P=0.022). Conclusions Vaginal hysterectomy is superior to abdominal hysterectomy in obese women, but should be used with caution in those with severe adhesions or multiple abdominal operation history.

AIM To investigate the effect of ke tamine on ATP-sensitive K + currents (I K ATP ) in single airway smooth muscle (ASM) cells of asthmatic rat. METHODS Single ASM cells of asthmatic rat were isolated with enzymatic dissociation technique. Effect of ketamine on I K ATP in single ASM cells was studied using the whole-cell configu ration of patch clamp technique. RESULTS Ketamine opened the ATP -sensitive K + channel (K ATP channel) in a dose-dependent manner. When the concentrations of ketamine were 1?10 -7 ,1?10 -6 ,1?10 -5 and 1?10 -4 mol?L -1 , the amplitude values of I K ATP were increased to 63 86?19 33 pA/pF(n=8,P