Cancer stem cells(CSCs) are a group of tumor cells with stem cell-like properties such as infinite self-renewal and multi-differentiation potential. Accumulating evidence strongly indicates the presence of cancer stem cells in a variety of solid tumors. Although rare, CSCs play important roles in tumor initiation, progression, recurrence and metastasis. Research of gastric cancer stem cells is still in its infancy. Specific surface markers of gastric CSC are yet to be identified. Active researches are currently underway to investigate the existence and source of CSC in gastric cancer.

Objective:To report one case of hilar hepatic tumor treated by ultrasound-guided percutaneous puncture 125 I radioactive seed implantation,and to review the associated literatures.Methods:One patient’s CT and ultrasonic examinations were taken,and the plan of TPS was taken.The patient was treated by ultrasound-guided percutaneous puncture 125 I radioactive seed implantation according to the plan of TPS.The needles were parallel, and the distance between the seeds were 1.0 to 1.5 cm. Results:The operation was successfully completed.No postoperative complications were encountered during 1 month follow up.The volume of tumor was obviously reduced 1 month after operation detected by ultrasound and CT. The local control effect of tumor was good.Conclusion:Ultrasound-guided percutaneous puncture 125 I radioactive seed implantation is a safe and effective method in treating hilar hepatic tumor.

Objective To explore the influence of Shensongyangxin capsule on plasma high-sensitivity C-reactive protein(hs-CRP) and N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with persistent atrial fibrillation after cardioversion.Methods 152 patients with persistent atrial fibrillation were randomly divided into the observation group(76 cases)and the control group (76 cases).All patients were conducted atrial cardioversion.The patients were followed up for 12 months.The plasma hs-CRP and NT-proBNP were measured before and after treatment.Results All patients with atrial fibrillation were cardioversed to sinus rhythm after cardioversion.During 12 months of follow-up,in the observation group 2 patients had recurrence of atrial fibrillation and in the control group,nine cases of recurrence,the difference between the two groups was significant (x2 =5.28,P ＜ 0.05).After treatment,the plasma hs-CRP and NT-proBNP in the two groups were significantly decreased(t =7.270,3.601,8.118,3.006,P ＜ 0.05,P ＜ 0.01),and those in the observation group were significantly lower than control group (t =4.720,2.914,all P ＜ 0.05).Conclusion Shensongyangxin capsule can significantly reduce plasma hs-CRP and NT-proBNP in patients with persistent atrial fibrillation after cardioversion.

Objective:To explore influence of critical care unit (CCU)clinical nursing pathway (CCU-CNP)in de-partment of cardiology on quality of life in patients undergoing coronary artery bypass grafting (CABG).Methods:A total of 128 patients undergoing CABG,who hospitalized in our CCU from Jun 2012 to Jun 2014,were selected. According to random number table,patients were equally divided into CCU-CNP group and routine nursing group. Changes of quality of life and disease knowledge level were compared and analyzed between two groups before and after intervention.Results:Compared with routine nursing group,after intervention,there were significant rise in scores of anginal stability [(60.12±4.36)scores vs.(77.36±5.46)scores],physical limitation [(68.02±3.98) scores vs.(86.98±4.58)scores],anginal frequency [(60.28±5.12)scores vs.(78.47±3.45)scores],disease per-ception [(61.89±4.36)scores vs.(82.58±5.89)scores]and treatment satisfaction [(63.38±5.23)scores vs. (83.92±6.21)scores],P <0.05 or <0.01;and significant reductions in CCU time [(6.98±1.32)d vs.(3.32± 1.22)d],mean hospitalization time [(12.87±2.66)d vs.(6.36±2.45)d]and incidence rate of adverse cardiac events (14.06% vs.3.13%)in CCU-CNP group,P <0.05 or <0.01. Conclusion:CCU clinical nursing pathway can effectively raise disease knowledge and quality of life,reduce the incidence of adverse cardiac events,shorten CCU time and improve patient′s prognosis in CABG patients.

Objective:To study the influence of TNF-? on the expression of secretory component (SC) in Caco-2 cells.Methods:Immunocytochemistry,ELISA,Western blot and quantitative real-time PCR were used to test SC-positive cells of Caco-2,free SC in culture supernatants,protein and mRNA expression of SC in the cells.Results:The increase of SC-positive cells,free SC in culture supernatants,SC protein expression and expression of SC genes in Caco-2 cells was found under stimulation of TNF-? treatment compared with control(P

Objective To investigate the effects of Chinese drugs for nourishing Yin and clearing the heat on regulation of sex hormones and clinical efficacy patients with SLE.Methods Fifty four active SLE patients with Yin deficiency were randomly divided into 2groups.Thirty patients in tr eatment group were treated with Pill of Wind-weed Phellodendron and Rehman nia(Zhibai Dihuang Wan)and Bolus for Replenishing Vital Ess ence(Da Buyin Wan)combined with western medicine for 2months,while 24patients in control group were treated with western medicine alone.Before and a fter treatment,the serum levels of f ollicle-stimulating hormone(FSH),luteinizing hormone,estradiol,pr ogesterone,testosterone,prolactin were measured by ELISA in 54patien ts,respec-tively.Before treatment the serum l evels of FSH,luteinizing hormone,estradiol,progesterone,testosterone,prolactin were measured in 30active SLEpatien ts without Yin deficiency and 25age-matched healthy controls simultaneously.Results The mean levels of FSH,luteinizing h ormone,estradiol were significant ly higher in patients with Yin de-ficiency than those without Yin deficiency and those in heathy controls(P

Objective To investigate the risk factors of flare in systemic lupus erythematosus(SLE).Methods In this retrospective cohort study132cases of SLE were followed up for1～5years.The risk factors of SLE flare were analyzed by univariate and multivariate logistic regression with computer software,SPSS.Results Of the132patients,82cases had more than one flare,the total number of flares was115.The incidence of flare was0.22per patient-year.The frequency of flares within5years after diagnosis of SLE was higher than that in more than5years.By univariate logistic regression analysis the age younger than40years at the beginning of the study,age of disease onset younger than32years,stress,depression,overwork,pregnancy,suffering from infectious disease,and quick decreasing of prednisone dosage significantly increased the risk of flare(P

OBJECTIVE To find out the clinical characteristics of nosocomial infections with Stenotrophomonas maltophilia(SMA) and investigate the disinfectant resistant gene of qacE△1,improve the diagnosis and decrease of nosocomial infection cases.METHODS Toally 165 strains of SMA were clinically isolated from 2004 to 2007.The gene of qacE△1 was analyzed by polymerase chain reation(PCR) and homology of the strains was analyzed by the method of by pulsed field gel electrophoresis(PFGE) genotype.RESULTS Susceptible factors were old age,seriousness of underlying disease,prolonged hospitalization and invasive operation with infection of SMA.The lower respiratory tract infection was mostly common with SMA,rate of which was 87.9%.Antibiotic sensitive rate more than 80% against SMA was minocycline,trimethoprim-sulfamethoxazole and levofloxacin.The positive rate of gene qacE△1 was 13.3% in 60 strains tested.Two genotypes in SMA strains from respiratory ICU(RICU) were with the same clone.This result proved that clone transmission occurred in RICU.CONCLUSIONS SMA is an important nosocomial infection pathogen.With the multi-drug resistance,the therapy of infection with SMA is very hard in clinic.As result of gene of qacE△1 and the same clone transmission,clinicians should play an important role of surveillance of effect of disinfection.

Objective To study the efficacy of Ciwujia injection combined with electric acupuncture in the treatment of arteria vetaebralis vertigo.Methods 66 cases with arteria vertebralis vertigo were randomly recruited into a control group with 30 cases and a treatment group with 36 cases.The treatment group was administered with Ciwujia injection and electric acupuncture for 10 days,and the control group was administered with flunarizine and Danshen injection for 10 days.Resuits After 10 days'therapy,thetotal effective rate and the cure ratewas 91.7%and 30.6%in the treatment group,and the total effective rate and the cure rate was 63.3%and 16.7%in the control group.There was statistical diflerence between the two groups(P＜0.05).Conclusion The therapy of Ciwujia injection and electric acupuncture has good effect in treating arteria vertebralis vertigo.

Objective To investigate the therapeutic effects of Yangxin Ningshen capsule in the treatment of insomnia. Methods 78 patients were randomly recurited into a control group (36 cases) and a treatment group (42 cases). The treatment group was administered with 1.6g to 2.0g Yangxin Ningshen capsule, three times daily, for 28 days. The control group was administered with Valium and Orgzanol tablets for 28 days. After 4 weeks therapy, the clinical effect was evaluated. Results The total effective rate and cure rate was 92.85% and 47.62% respectively in the treatment group. The total of effective rate and cure rate was 83.33% and 30.56% respectively in the control group, There was statistical difference between the two groups (P<0.05) .Conclusion The therapy of Yangxin Ningshen capsule has good effects in treating insomnia.