Objective To analyze the causes of death in patients with uremia during maintenance hemodialysis and explore the countermeasures for improving life quality and decreasing mortality.Methods A retrospective analysis was made on the clinical and hemodialysis material fo 145 patients with MH to analysis the causes of death.Results The total number of deaths was 38;cerebral hemorrhage 6,heart failure 16,infection 5,the mean age in the deceased group was older than that in the survival group.The systolic blood pressure in the deceased group was higher than that in the survival group,but the levels of serum albumin,serum total cholesterol,serum creatinine,and urea nitrogen in the deceased group were much more lower than those in the survival group.The mean duration of hemodialysis in the deceased group was shorter than that in the survival group.Conclusion Cardiovascular disease and severe infections were the leading causes of death in patients with maintenance hemodialysis.Controlling the inter-dialysis weight gain and blood pressure,improving the anemia and main-nutrition were the significant management of prevention of cardiovascular complications.

Objectives To evaluate the application of systemic octreotide radioactive imaging in diagnosis and follow-up for children with neruoblastoma (NB). Methods Clinical data of 14 children with NB applied systemic octreotide radioac-tive imaging from April 2006 to March 2011 were collected and analyzed. For the ifrst-visit patients, they were applied with systemic octreotide radioactive imaging at the ifrst follow-up appointment after routine treatment. And for recurrent or sus-pected recurrent cases, systemic octreotide radioactive imaging was applied before the treatment and after 2-3 weeks chemo-therapy. Results Nine of 14 patients were male and 5 were female with a median age of 4.8 years (1-10 years). According to In-ternational Neuroblastoma Staging System (INSS), 4 cases were categorized as stage 3 and 10 cases were categorized as stage 4. The uptake rate of systemic octreotide radioactive imaging in primary site or metastasis sites of 8 cases were higher than nor-mal site with positive rate of 57.14%(8/14). One case was conifrmed as false positive by treatment and imaging examination. Six cases were negative in primary site or metastasis sites with negative rate of 42.86%(6/14). One case was conifrmed as false negative via treatment and imaging examination. Therefore, the sensitivity of systemic octreotide radioactive imaging reached 85.71%(12/14). Conclusion Systemic octreotide radioactive imaging could be one of the effective methods for NB in diagno-sis, follow-up and evaluation of prognosis.

Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease characterized by progressive loss of upper and lower motor neuron. Insomnia is one of the widespread but underappreciated non-motor symptoms in ALS patients, which may not only seriously affect patients′ quality of life, but also reflect the lesions of central nervous system in ALS. This review summarizes the insomnia symptoms reported in current ALS studies, and summarizes the somatic factors and central nervous system changes associated with insomnia in ALS patients, so as to provide ideas for the development of effective intervention measures and future research.

Apolipoprotein E (ApoE) was purified from human serum and used as the antigen to immunize BALB/C mice. The splenic cells of the mice fused with NS-1 mouse myeloma cells. Three hybridoma cell lines(E3C3, E6C3 and E4C2)secreting anti-human ApoE McAb were established. The immunological property of the McAb was studied. The ascites fluids titer were 8?10~(-5)2?10~(-6). The McAbs did not cross react with the other apolipoprotins. ApoE was purified by immunoaffinity chromatography prepared by using the ApoE McAb. McAbs recognized two distinct respective epitopcs on ApoE. The subclass of immunoglabulin of three McAbs were IgG_1. A double McAb sandwich EL1SA was developed to evaluate ApoE levels in normal and hyperlipidemia human serum.

Objective To investigate relationships between serum asymmetric dimethylarginine (ADMA) and transient ischemic attack (TIA).Methods Forty hcalthy controls and 40 patients with TIA were enrolled in the present study.ABCD2 score was used to evaluate risk for future stroke.Serum ADMA levels were measured with ELISA analysis.Results Serum level of ADMA was higher in TIA group than that in control group [(0.52 ± 0.06) mmol/L vs (0.23 ± 0.04) mmol/L,P ＜ 0.05].In TIA subgroup,19 cases(47.5％)developed cerebral infarction and 23 cases(57.5％)had no stroke history.There is positive correlation between serum ADMA levels and ABCD2 score in both cerebral infarction subjects (r =0.560,P =0.013),and no stroke history cases(r =0.602,P =0.002).TIA subjects were,then,divided in to two groups based on ABCD2 score as 0-3 group and ≥ 4 group.In general linear model analysis,ADMA level was associated with ABCD2 score (F =4.39,P =0.043) after adjusted for age and gender.This situation hold true for subjects within cerebral infarction group (F =7.327,P =0.017) or non-previous stroke group(F =12.300,P =0.002).No association could bc found between ADMA level and ABCD2 score grouping in subjects with non-infarct (F =0.523,P =0.675) or stroke history (F =0.274,P =0.609).Conclusions Elevated ADMA is associated with occurrence of TIA.Endothelial dysfunction may play an important role in the pathogenesis of TIA.

Objective To discuss the relationship of metabolizing enzyme Cystathionine βsynthase (CBS) G919A gene polymorphism with essential hypertension on Hui nationality in Xinjiang. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the gene polymorphism, blood lipid, blood sugar and other biochemical indicators were tested at the same time. Result The distribution frequency of genotype GG, GA, AA and A,G, of CBS G919A was 76.4%, 19.0%, 4.5%, which was of no significant difference compared with the control group (P > 0.05). Conclusion Gene polymorphism of CBS G919A was existed, which was no relationship with essential hypertension on Hui nationality in Xinjiang.

Objective To investigate effect of hydroxypropyl methyl cellulose (HPMC) to in vitro release characteristics of cefaclor sustained-release tablets.Methods Collected 10 batches of HPMC from different manufacturers.Determined the viscosity, molecular weight and the distribution of molecular weight of HPMC.HPMC from different manufacturers was used as blocking agent for the preparation of cefaclor sustained-release tablets according to the same prescription.Results The molecular weight was positively related to the viscosity of HPMC.The more molecular weight was, the slower the drugs release rate was,the better controlled released.Conclusion HPMC from different manufacturers show different quality stability and effect in vitro release of cefacor sustained-release tablets.

Objective: To evaluate the effect of Chinese herbal medicine on Chronic Periodontitid.(CP).Method:34 patients with CP were randomly divided into two groups.The herbal medicine was given to the experiment group for two months,while the other group was set as a blank control.The Periodontitid and laboratory test indexes such as PLP,PPDPAL,MD and Ca P,ALP of patients were measured before and after treatment.Results: The indexes of patients in the group of Chinese herbal medicine were statistically signifi cant in contrast with the control group(P

Objective:To discuss the effect of Jianpi Shugan Huoxue Prescription on ICAM-1 gene expression in H22 hepatic cancer mice. Methods: Animal model of H22 hepatic cancer mice were established by inoculating tumor cell. Mice were randomly divided into six groups: the normal group, the model group , Cyclophosphamide group, low, middle and high dosage groups of Jianpi Shugan Huoxue Prescription. The gene expression of ICAM-1 were detected by reverse-transcription polymerase chain reaction (RT-PCR). Results: Compared with model group, the contents of ICAM-1 in serum in the middle and high dosage groups of Jianpi Shugan Huoxue Prescription both decreased(P

Heat shock protein (HSP) is a family of poly-peptdic-proteins with many members. A great deal of data show that heat shock proteins act as molecular chaperones to regulate protein folding, translocation and assembly, it can combine with other peptidic-proteins existing in cells and participating in the process of anti-damage, repair and thermotolerance of cells. In recent years, with the progress of research in this field, it has arisen extensive attentions of the application of heat shock proteins in etiology , therapeutics and prevention of tumor. HSP becomes one of the most active research field.