Objective To investigate the cost-effect of tele-wound treatment platform with cellular phone terminator and traditional outpatient treatment on chronic lower limb ulcers in remote district.Methods Thirty seven cases with chronic lower limb ulcers from the key hospitals in the district of west Hunan Province were collected by cluster sampling,and randomly divided into the intervention group (25 cases)and the control group (12 cases).They chose remote wound treatment platform intervention with cellular phone terminator and traditional dressing change in clinic.All patients received a 1.5-year follow-up,or cure and amputations were set as the endpoint of the study.The cost-effect,including the incidence of complications in the course of treatment,number of switches,treatment time,the cost of treatment,as well as medical human resources consumption was analyzed and compared between the two groups.Results The incidence of complications in the course of treatment in the intervention was (76.0％) significantly lower than the control group(91.7％).There was a significant increase in the dressing times and the duration of treatment; and there was no significant difference in the cost of treatment and medical human resources consumption between two groups.Conclusions Compared to the traditional outpatients wound treatment,the multimedia message-based tele-wound treatment platform unlikely increased medical human resources consumption and the cost of treatment,and may reduce the incidence of complications and the treatment time.

Objective To investigate the role of the ATP binding box C subfamily 2 transporter protein (ABCC2) gene in drug-resistant epilepsy.Methods From February 2014 to February 2018,204 epileptic patients were treated in our hospital,including 41 cases of drug resistance epilepsy (drug resistance group),163 cases of non drug resistant epilepsy (sensitive group).The rs717620 polymorphism of ABCC2 gene and the level of P-glycoprotein (P-gp) in cerebrospinal fluid and serum were detected in two groups.Results The proportion of genotype TT and gene frequency T in the drug resistant group were 24.39％ and 41.46％,respectively,which were significantly higher than those in the sensitive group (P ＜ 0.05).The concentration of P-gp in cerebrospinal fluid of drug resistant group was (21.03 ± 4.21) ng/ml,which was significantly higher than that of the sensitive group (P ＜ 0.05).There was no significant difference in serum P-gp concentration between the drug resistant group and the sensitive group (P ＞ 0.05);The concentration of P-gp in cerebrospinal fluid of patients with genotype TT in drug resistance group was (24.03 ± 3.57) ng/ml,which was significantly higher than that of type CC and CT (P ＜ 0.05).There was no significant difference in the concentration of P-gp in the patients with different genotypes in the drug resistant group (P ＞ 0.05).Conclusions The rs717620 polymorphism of ABCC2 gene may be associated with drug-resistant epilepsy,and may be related to P-gp level in the cerebrospinal fluid.

Objective To explore the compliance of rehabilitation training and its influencing factors in patients with post-stroke dysphagia (PSD). Methods The clinical case data of 320 PSD patients in the hospital were retrospectively analyzed from January 2020 to December 2023. According to the evaluation results of rehabilitation exercise adherence questionnaire (EAQ), PSD patients were divided into good compliance group (compliance index≥50%) and poor compliance group (compliance index<50%). The compliance of PSD patients was recorded. Univariate analysis and Multivariate logistic regression analysis were adopted to analyze the independent risk factors leading to poor compliance of PSD patients. Results The evaluation results of rehabilitation training compliance of PSD patients showed that the overall rehabilitation training compliance index was 53.04% and the proportion of poor compliance was 41.25%. Univariate analysis showed that there were statistical differences in age, Barthel index<40 points, Family Assessment Device (FAD) score, Stroke Knowledge Questionnaire (SKQ) score, Stroke Self-Efficacy Questionnaire (SSEQ) score, Brief Illness Perception Questionnaire (BIPQ) score and Short Form Health Belief Model Scale (SF-HBMS) score between the good compliance group and the poor compliance group (P<0.05). Multivariate logistic regression analysis indicated that age, Barthel index<40 points and FAD score were independent risk factors for poor rehabilitation training compliance in PSD patients (P<0.05), and SKQ score, SSEQ score, BIPQ score and SF-HBMS score were protective factors (P<0.05). Conclusion PSD patients generally have unsatisfactory rehabilitation exercise compliance. Age, daily living ability and family function are risk factors for poor compliance.