Objective To explore the role of medical insurance in the treatment of the coronary heart disease(CHD) out-patients with or without medicare. Methods 92 CHD out-patients from the medicare department and 92 CHD out-patients from general department of Shandong Taishan Chronic Disease Hospital were investigated and comparatively analyzed on their clinical data in the past 1 year,including the times of hospital visiting,compliance with doctor's instruction,blood pressure,serum lipids and blood glucose control and evaluation of treatment effect based on their clinical symptoms and ECG records.Results The compliance with doctor's instruction,blood lipids,blood pressure control of out-patients in medicare department were significantly better than those in general department(P

BACKGROUND: At present, bone defects usually repaired by autologous bone, allogenic bone, synthetic bone substitutes and other methods, which received poor clinical results. Preliminary studies have shown that adipose-derived mesenchymal stem cells (ADSCs) possess strong proliferation ability and differentiation potential, and can be induced differentiate into bone. OBJECTIVE: To analyze the application of ADSCs in bone tissue engineering, and to identify whether ADSCs can be used as seed cells in bone tissue engineering. METHODS: The databases of PubMed (1999-01/2008-12) and Tongfang (2003-01/2008-12) was retrieved using key words of "adipose tissue-derived mesenchymal stem cells, adipose mesenchymal stem cells, adipose stem cell; osteogenic induction, osteogenic inducement, bone induction, osteoblastic induced; chondroblast induction, cartilage induction; bone tissue engineering, tissue engineering bone, tissue engineering of bone". RESULTS AND CONCLUSION: A total of 361 literatures were collected, including 246 in Chinese and 115 in English. Totally 29 literatures were accordant with the study criteria. ADSCs is a truly multi-directional differentiation potential cells, which possess strong amplification and self-renewal potential, and can be directional differentiated into osteoblasts, cartilage cells, bone cells and muscle cells. It can be used as seed cells in bone tissue engineering when matching appropriate stents.

Stranging the communication between the clinical laboratory and clinical department,is useful to promote and enhance the quality of tests and clinical examination.The communication work organization and implementation has been effectively guaranteed by managing communication theories and multiple pathways of communication means to strengthen clinical laboratory and clinical department communication.

Objective To investigate the variation of middle cerebral arteries of rats in depression model by using 3D-TOF sequence on 3.0T MR.Methods Forty SD rats were randomly divided into control group and depressive group with 20 in each.Compared with control group,depressive group were handled according to the demand of rat depression model.Rats were scanned by 3.0T MR on 0th,4th,6th,8th week respectively.Using Mimics software,the variation of middle cerebral arteries were described and analysed.Results Compared with the control group,the middle cerebral arteries of depressive group rats changed along with the increase of time.On the 4th week,the diameter of the middle cerebral arteries of rats decreased significantly (the diameter of left middle cerebral arteries:control group (0.31 ±0.05) mm,depressive group (0.28±0.04) mm,t=2.76,P＜0.05 ; the diameter of right middle cerebral arteries:control group (0.30 ± 0.05) mm,depressive group (0.27± 0.03) mm,t =2.61,P＜ 0.05).On the 6th week,the length of the middle cerebral arteries of rats decreased significantly (the length of left middle cerebral arteries:control group (5.6± 0.77) mm,depressive group (4.9 ± 0.73) mm,t =2.84,P＜ 0.05 ; the length of right middle cerebral arteries:control group(5.5±0.76) mm,depressive group(4.8±0.72) mm,t=3.11,P ＜0.05).On the 8th week,the diameter and length of the middle cerebral arteries of rats decreased more significantly (the diameter of left middle cerebral arteries:control group (0.31 ±0.05) mm,depressive group (0.22±0.02) mm,t =5.50,P＜ 0.01 ; the diameter of right middle cerebral arteries:control group (0.30 ± 0.04) mm,depressive group (0.21 ±0.02) mm,t=5.57,P＜0.01 ; the length of left middle cerebral arteries:control group (5.6±0.78) mm,depressive group (4.3±0.70)mm,t=5.49,P＜0.01 ;the length of right middle cerebral arteries:control group (5.5 ± 0.79) mm,depressive group (4.2±0.71)mm,t=5.45,P＜0.01).Conclusion The variation of middle cerebral arteries of depressive rats reveals the relationship between brain vessels and depression in a certain extent.

Objective To investigate the CT and MRI findings of primary hepatic neuroendocrine carcinomas.Methods Imaging findings of 6 patients with pathologically confirmed hepatic neuroendocrine carcinomas were retrospectively analyzed.Four patients underwent plain CT and contrast enhanced CT examinations.The other 2 patients underwent plain MRI and contrast enhanced MRI.Results One out of the 6 cases manifested multicentric tumor which appeared as one large tumor surrounded with multiple small nodules peripherally,and the tumors of the other 5 cases were solitary.On plain CT images,all lesions were well-defined and hypoattenuating with central areas of even lower density except punctuate calcifications at tumor periphery in 1 case.On pre-contrast MRI,the cases manifested heterogeneous low signal intensity on T1 wI and slightly high intensity on T2 WI.On dynamic contrast enhanced CT and MRI,Tumors manifested slight to mild enhancement in arterial phase,slight enhancement in portal venous phase or delayed phase with no enhancement in the center,accompanied by dislocation of surrounding vessels.There Was no lymphadenopathy in peritoneal cavity and retroperitoniurm. Conclusion CT and MRI scanning can demonstrate specific features of primary hepatic neuroendocrine carcinoma,which may help the diagnosis and differential diagnosis of the tumor.

Psychiatric disorders with the chief feature of psychiatric symptoms are different from body diseases, traditional syndrome differentiation and treatment of Zang and Fu based on somatic symptoms is not adapted to the psychiatric clinical practice, so the new method of syndrome differentiation and treatment should be established. The new method must be guided by the methodology of Chinese Medicine (CM) . Thinking of imagine is the core of CM, and formation of the CM theory and syndrome differentiation and treatment of clinical course also reflect this thinking model.The new method of syndrome differentiation and treatment based on psychiatric symptoms must be guided by the methodology of thinking of imagine, so this paper discussed the significance in establishing the new method of syndrome differentiation and treatment based on psychiatric symptoms from the methodology of thinking of imagine, and this paper perhaps provided an idea for the establishment of syndrome differentiation and treatment of psychiatric disorders.

The pathogenesis of tourette syndrome is not clear yet, and the clinical manifestations are diverse. With modern medi-cal treatment, adverse reactions occur frequently in clinics. Based on syndrome differentiation, TCM treatment can well control the clinical symptoms of children, and achieve better results without obvious adverse reactions. TCM treatment has unique advantages. In the paper, the etiology and pathogenesis, and the classification of the disease were discussed, so as to systematically explore TCM treatment of the disease and provide reference for TCM treatment of the disease.

Objective:To summarize and sort out the best evidence for sleep disorders management in children with autism spectrum disorder.Methods:Literatures related to sleep disorders management in children with autism spectrum disorder were systematically retrieved on UpToDate, BMJ Best Practice, National Guidelines Clearinghouse, Registered Nurses' Association of Ontario, Scottish Intercollegiate Guidelines Network, National Institute for Health and Clinical Excellence, Guidelines International Network, World Health Organization website, Medlive, Joanna Briggs Institute evidence-based healthcare center database, Web of Science, Cochrane Library, PubMed, Embase, CINAHL, PsychInfo, China Biology Medicine disc, Wanfang Database, CNKI, VIP, Association for Science in Autism Treatment website, Autism Society website, National Autism Society website and other domestic and foreign databases and websites. Literature types included guidelines, systematic review/Meta-analysis, evidence summary, clinical decision making and expert consensus. The search deadline was from the establishment of the databases to November 30, 2022. Two researchers trained in systematic evidence-based knowledge evaluated literature quality and extracted evidence.Results:A total of 14 literatures were included, including 1 clinical decision, 4 guidelines, 7 expert consensus and 2 systematic reviews. A total of 32 pieces of evidence were formed from 8 aspects, including screening, assessment, sleep planning, treatment goals, intervention, follow-up, caregiver support and team management of children with autism spectrum disorder.Conclusions:This study summarizes and forms the best evidence on the management of sleep disorders in children with autism spectrum disorder, and provides an evidence-based basis for the management of sleep disorders in them.

Objective To explore the expression levels of cholinesterase(CHE)and haptoglo-bin(HPT)in serum of children with recurrent respiratory tract infections(RRTI)and their value in evaluation of prognosis.Methods A total of 112 children with RRTI were selected and included in the RRTI group,and 95 normal children who underwent physical examination during the same period were randomly selected and included in control group.According to the severity of the disease,pa-tients in the RRTI group were divided into mild group of 38 cases,moderate group of 40 cases,and severe group of 34 cases.The levels of serum CHE,HPT,interleukin-1(IL-1),interleukin-6(IL-6),immunoglobulin A(IgA),immunoglobulin M(IgM),as well as CD3+and CD3+CD4+were detected.The correlation between CHE and HPT in RRTI children was analyzed.The predictive value of serum CHE and HPT expression levels on the prognosis of RRTI children was analyzed.Results The CHE expression level in the RRTI group was significantly lower than that in the control group,while the HPT level was significantly higher(P＜0.05).The CHE level in severe RRTI patients was signifi-cantly lower than that in the moderate and mild groups,and the moderate group was significantly lower than the mild group;the HPT level in severe RRTI children was significantly higher than that in the moderate and mild groups,and the moderate group was significantly higher than the mild group(P＜0.05).The CHE expression level in RRTI children was negatively correlated with the HPT ex-pression level(r=-0.637,P＜0.001).The levels of IL-1,IgA,IgM,CD3+and CD3+CD4+,in the RRTI group were significantly lower than those in the control group,while the IL-6 level was significantly higher(P＜0.05).The CHE expression level in RRTI children was positively correla-ted with IL-1,IgA,IgM,CD3+and CD3+CD4+,and negatively correlated with IL-6;the HPT ex-pression level was negatively correlated with IL-1,IgA,IgM,CD3+and CD3+CD4+,and positive-ly correlated with IL-6(P＜0.05).The serum CHE expression level in RRTI children with good prognosis was significantly higher than that in RRTI children with poor prognosis,while the HPT level was significantly lower(P＜0.05).The area under the curve(AUC)of the combined predic-tion of CHE and HPT for the prognosis of RRTI children was higher than that of their individual pre-dictions,and the difference was statistically significant(P＜0.05).Conclusion In the serum of RRTI children,CHE is lowly expressed,while HPT is highly expressed.The combined evaluation of CHE and HPT has high prognostic value for RRTI patients.

Objective To explore the expression levels of cholinesterase(CHE)and haptoglo-bin(HPT)in serum of children with recurrent respiratory tract infections(RRTI)and their value in evaluation of prognosis.Methods A total of 112 children with RRTI were selected and included in the RRTI group,and 95 normal children who underwent physical examination during the same period were randomly selected and included in control group.According to the severity of the disease,pa-tients in the RRTI group were divided into mild group of 38 cases,moderate group of 40 cases,and severe group of 34 cases.The levels of serum CHE,HPT,interleukin-1(IL-1),interleukin-6(IL-6),immunoglobulin A(IgA),immunoglobulin M(IgM),as well as CD3+and CD3+CD4+were detected.The correlation between CHE and HPT in RRTI children was analyzed.The predictive value of serum CHE and HPT expression levels on the prognosis of RRTI children was analyzed.Results The CHE expression level in the RRTI group was significantly lower than that in the control group,while the HPT level was significantly higher(P＜0.05).The CHE level in severe RRTI patients was signifi-cantly lower than that in the moderate and mild groups,and the moderate group was significantly lower than the mild group;the HPT level in severe RRTI children was significantly higher than that in the moderate and mild groups,and the moderate group was significantly higher than the mild group(P＜0.05).The CHE expression level in RRTI children was negatively correlated with the HPT ex-pression level(r=-0.637,P＜0.001).The levels of IL-1,IgA,IgM,CD3+and CD3+CD4+,in the RRTI group were significantly lower than those in the control group,while the IL-6 level was significantly higher(P＜0.05).The CHE expression level in RRTI children was positively correla-ted with IL-1,IgA,IgM,CD3+and CD3+CD4+,and negatively correlated with IL-6;the HPT ex-pression level was negatively correlated with IL-1,IgA,IgM,CD3+and CD3+CD4+,and positive-ly correlated with IL-6(P＜0.05).The serum CHE expression level in RRTI children with good prognosis was significantly higher than that in RRTI children with poor prognosis,while the HPT level was significantly lower(P＜0.05).The area under the curve(AUC)of the combined predic-tion of CHE and HPT for the prognosis of RRTI children was higher than that of their individual pre-dictions,and the difference was statistically significant(P＜0.05).Conclusion In the serum of RRTI children,CHE is lowly expressed,while HPT is highly expressed.The combined evaluation of CHE and HPT has high prognostic value for RRTI patients.