Objective:To study changes of ECG and cardiac enzyme levels in patients with arrhythmia after in‐hospital infection .Methods :A total of 71 patients with arrhythmia complicated in‐hospital infection ,who were treated in our hospital ,were selected .ECG and cardiac enzyme levels were measured in all patients at hospitalization and after in‐hospital infection .ECG and cardiac enzyme levels were observed and compared between before and after infec‐tion .Results:Compared with before infection ,after infection ,there were significant rise in percentages of sinus tachycardia (29.58% vs .50.70% ) ,bundle branch block (22.54% vs .40.85% ) ,premature ventricular contraction (57.75% vs .78.87% ) and premature atrial contraction (70.42% vs .95.77% ) , P<0.05 or <0.01 ;significant in‐crease in percentages of ST‐T changes (19.72% vs .94.37% ) ,abnormal ST segment (35.21% vs .69.01% ) and ab‐normal PR interval (71.83% vs .94.37% ) , P<0.01 all;and significant rise in levels of creatine kinase isoenzyme [ (29.66 ± 7.54) U/L vs .(44.68 ± 8.93) U/L] and creatine kinase [ (283.65 ± 36.84) U/L vs .(329.47 ± 35.56) U/L] , P<0.01 both .Conclusion:After in‐hospital infection ,the percentages of arrhythmias and abnormal change of ECG wave and cardiac enzyme levels significantly rise in patients with arrhythmia ,physicians should strive to pre‐vent in‐hospital infection ,the patient's condition aggravation .

Objective: To study significance of detection of serum levels of high sensitive C reactive protein (hsCRP), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) for assessing patient’s condition in patients with coronary heart disease (CHD). Methods: Serum levels of hsCRP, TNF-α and IL-8 were measured in 78 CHD patients undergoing percutaneous coronary intervention (PCI) before and three months after PCI. Among CHD patients, there were 17 patients with acute myocardial infarction (AMI), 36 patients with unstable angina pectoris (UAP) and 25 patients with stable angina pectoris (SAP). Their levels of above indicators were compared with those of 47 healthy subjects (normal control group). Results: （1）Compared with normal control group, there were significant increase in serum levels of hsCRP [ (1.96±0.60) mg/L vs. (22.43±9.68) mg/L, (18.27±8.56) mg/L], TNF-α [ (11.26±3.82) ng/L vs. (60.12±19.37) ng/L, (40.33±15.48) ng/L] and IL-8 [ (48.26±20.87) ng/L vs. (120.36±33.32) ng/L, (105.92±34.2) ng/L] in AMI group and UAP group before treatment (P<0.01 all), and Pearson linear correlation analysis showed that hsCRP was positively correlated with levels of TNF-α and IL-8 (r=0.873~0.956, P<0.01 all); （2）Serum level of hsCRP in SAP group [(6.04±2.38) mg/L] was significantly higher than that of normal control group (P<0.01); （3）Compared with before PCI, there were significant decrease in serum levels of hsCRP[(13.89±6.13) mg/L vs. (2.06±1.42) mg/L], TNF-α[(38.26±14.27) ng/L vs. (13.76±4.12) ng/L] and IL-8[(98.96±32.9) ng/L vs. (50.12±19.85) ng/L] in CHD patients three-month after PCI (P<0.01 all), and they were no significant difference compared with normal control group (P>0.05 all). Conclusions: Detections of serum levels of hsCRP, TNF-α and IL-8 in CHD patients are of certain significance for diagnosis, treatment and prognosis prediction of CHD.

Objective To determine the prevalence of pain beyond the osteoporotic vertebral com-pression fracture (OVCF) in patients undergoing percutaneous vertebral augmentation and the response of pain to the treatment. Methods A retrospective study of 104 patients undergoing percutaneous vertebral augmentation (pereutaneous vertebroplasty and pereutaneous kyphoplasty) was performed to examine the lo-cations and severities of pain beyond the OVCF before and after operation. The Visual Analog Sscale (VAS,10-point scale) and Activities of Daily Living (ADL, 5-point scale) were used. Results Of the 104 patients, 48 (46.2%) suffered pain beyond the OVCF. The pain was firstly located in the sacrococeygeal region and buttocks (26.0%), secondly in the abdomen and sub-xiphoid process (10.6%) and thirdly in the flank, ribs and chest (9.6%) . For all the cases, the mean VAS score decreased from 8.9±0. 8 before vertebral augmentation to 2.9±1.4 after augmentation (t=37.410, P=0.000), and the mean ADL score decreased from 4.1±0.6 before operation to 2.0±0.7 after operation (t=25.331, P =0.000) . For the patients suffering pain beyond the OVCF, the mean VAS score decreased from 8.8±0.9 before vertebral augmentation to 2.8±1.5 after augmentation (t=23.722, P=0.000), and the mean ADL score decreased from 4.2±0.7 before operation to 2.0±0. 7 after operation (t=15.373, P=0.000). The decreases in VAS and ADL scores were not affected by the pain. Conclusion The pereutaneous vertebral augmentation can effectively relieve the pain beyond the OVCF.

Aim To study the active constituents for the treatment of rheumatoid arthritis from the ethyl acetate extracts of the roots of Lasianthus acuminatissimus Merr. Methods Various chromatographic techniques were used to separate and purify the constituents. Their structures were established on the basis of 1D, 2D NMR and HRMS spectroscopic analyses and their preliminary evaluation of anti-inflammation effect on the release of β-glucuronidase was carried out. Results Eight compounds were isolated and identified as lasianthuslactone A ( 1 ) , codonolactone ( 2 ), 2, 5-dimethoxy-1,4-benzoquinone ( 3 ) ,uncargenin A (4) , nonadecyl alcohol (5) , 13-docosenoic acid (6) , tetracosanoic acid (7) and β-sitosterol (8). Compound 3 showed a significant inhibitory effect on release of β-glucuronidase rat polymorphous nuclear leukocytes activated by platelet activating factor (PAF). Conclusion Compound 1is a new one, the others were isolated from the plant for the first time and 3 is one of active antiinflammation compound in the plant.

AIM: To investigate the effects of oral administration of Astragalus membranceus, mung bean and arsenolite on the toxic of the arsenolite induced rats and the possible mechanisms with metallothionein (MT). METHODS: All the rats were oral administration with arsenolite. The Astragalus membranceus and mung bean were compared with the cadmium chloride which induced MT synthesis. The contents of MT were determined by cadmium saturation method, the liver mRNA levels for MT 1, MT 2 were detected by RT PCR. The protective effects of renal and liver were observed by testing alanine aminotransferase (ALT), blood urea nitrogen (BUN) and serum creatinine (SCR). RESULTS: The contents of MT were accorded with the mRNA expression of MT 1, MT 2. Arsenolite, Astragalus membranceus and mung bean could induce the synthesis of MT, but the contents of MT which arsenolite induced were trace. The contents of MT significantly increased after oral administration of Astragalus membranceus and mung bean, especially in the Astragalus membranceus group (P

Objective To investigate the changes and clinical significance of QT dispersion of patients with acute myocardial infarction especially those after thrombolitic therapy. Methods QTd, QTcd, QTLcd of 56 patients with AMI and 54 healthy people were measure through computer ECG. Results (1) The indexes of QTd in AMI group were significantly longer than normal ( P

ObjectiveTo evaluate the changes of Ag-NORs in patients with gallbladder carcinoma.MethodsAg-NORs in the peripheral blood lymphocytes,bile lymphocytes and the mucosa of gallbladder were detected by a cell image analysis of KL-2 in 20 normal volunteers,90 cholecystitis cases, and 20 gallbladder carcinomas. ResultsAg-NORs in peripheral blood lymphocytes (PBL) and bile lymphocytes (BL) in cholecystitis were lower than that in normal group(P

0.05).②The mean of SV, the mean of CO and the mean of CI in acute SAH group were lower than those in healthy persons group respectively (33.46?11.33 vs 52.67?12.46,P

Objective To examine the expression of p44/42 mitogen -activated protein kinase (p44/42MAPK) and Phospho-p44/42MAPK in cicatrix (hy pertropic scars and keloids) and to aim at exploring the role of activated p44/ 42 MAPK pathway in development of cicatrix. Methods In or der to analyse the differences, 10 samples of normal skin (NS), hypertropic scar s (HS) and keloids (K) were collected, and then the extracted cytoplasmic protei ns from each tissue were examined by Western blotting for p44/42 MAPK and Phosph o p44/42MAPK and immunohistochemical staining with specific antibodies was emplo yed to determine that in fibroblasts of K, HS and NS. Results There was no evident difference of p44/42MAPK in the tissues and fibroblas ts between cicatrix and NS, but Phospho-p44/42MAPK was obviously higher in cica trix than that in NS. In cicatrix, there was no evident difference of p44/42MAPK in tissues between HS and K, while in fibroblasts, Phospho-p44/42MAPK in K was much higher than in HS. Conclusion Activation of p44/42MA PK pathways involves in formation of cicatrix.

0.05).Conclusion Breath-hold MRCP utilizing the SSFSE technique with high-quality images can accurately assess the level of obstruction and the causes of the obstruction in patients with obstructive jaundice, without the risks of endoscopic retrograde cholangiopancreatography(ERCP).This MRCP technique should be preferred a reliable and noninvasive imaging modality for the diagnosis of obstructive jaundice.