OBJECTIVE:To make clear the market situation of anti-infectives which occupies an important place in drugs used in hospitals in China.METHODS:To analyse the market scale and developmental tendency of anti-infectives.RESULTS&CONCLUSION:Now,promoting and suppressing factors affecting the market expansion exist side by side in China.The charac?teristic of market is in absolute expansion of scale,and some drugs,such as cephalosporins,hold the major share of market.The increasing speed of market demand is slowing down year by year.

OBJECTIVE:To discuss about the strategy of technology advancement in pharmaceutical industry of Chi?na.METHODS:According to the analysis of comparative advantages of chemical pharmaceutical industry and industry of Chi?nese materia medica,the different competitive status of them was made definite.RESULTS&CONCLUSION:In the inter?national competition,Chinese traditional materia medica has distinctive advantage,while the chemical pharmaceutical industry lags behind,therefore the innovation strategy should be different between them.

OBJECTIVE: To discuss about the acceptability of the structural convergence of regional pharmaceutical indus- try. METHODS: According to the calculation of LQ and LQS2, the regional distributing structure of pharmaceutical industry was judged. RESULTS & CONCLUSION: The results showed that the regional distribution of pharmaceutical industry in China assumed characteristics of regional convergence. Because advanced technology and large scale are very important to pharmaceutical industry, the structural convergence of regional pharmaceutical industry is not acceptable.

Coronary heart disease and depression have a close relationship.Depression is common in patients with coronary artery disease and its presence is a strong independent risk factor for the development and adverse prognosis of coronary heart disease.The present review has summarized current knowledge of depression in patients with coronary artery disease regarding epidemiology,pathophysiologic pathways and treatment.

OBJECTIVE: To provide references for the improvement of drug safety of emergent public health events.METHODS: The characteristics of drug demands in emergent public health events were analyzed to guarantee the characteristics of drug safety so as to explore effective safeguard strategy.RESULTS & CONCLUSIONS: Special system and countermeasure are required to guarantee drug safety of emergent public health events.The strategy includes three aspects,i.e.adequate plan in advance,rapid response and timely consummation after the event.

OBJECTIVE: To discuss about the strategy of small and medium - sized pharmaceutical enterprises' develop-ment .METHODS: According to the analysis of different kinds of small and medium - sized pharmaceutical enterprises and the discussion of competition strategy, this paper brings forward the successful development model of small and medium - sized pharmaceutical enterprises.RESULTS & CONCLUSION: Small and medium - sized pharmaceutical enterprise advanced in technology is a successful development model in future. In order to get the development of this kind of enterprise, we should adjust our tactis in aspects of enterprise and goverment.

OBJECTIVE: To discuss about the strategy of small and medium-sized pharmaceutical enterprises' development.METHODS: According to the analysis of different kinds of small and medium-sized pharmaceutical enterprises and the discussion of competition strategy, this paper brings forward the successful development model of small and medium-sized pharmaceutical enterprises.RESULTS & CONCLUSION: Small and medium-sized pharmaceutical enterprise advanced in technology is a successful development model in future. In order to get the development of this kind of enterprise, we should adjust our tactis in aspects of enterprise and goverment.

Objective To investigate the evidence of effective therapy of transient ischemic attacks (TIA) through the study on the regional cerebral blood flow and the function of neurocyte in the symptom free phase Methods Forty one patients with TIA and 45 controls were examined by single photon emission computed tomography (SPECT), computed tomography cerebral perfusion imaging (CTPI) and the positron emission tomography (PET) Results The abnormal rate of SPECT examination was 95 1%, and abnormal perfusion rate of CTPI was 63 4% These results revealed that there were reduction of regional cerebral blood flow in above half of TIA patients SPECT showed abnormal in some patients with normal CTPI show, which was possibly because of abnormal function of neurocyte, and the latter was confirmed by PET Conclusion Patients with TIA should have not only abnormal function of neurocyte, but also have reduction of regional cerebral blood flow in the intermittent phase The therapy of TIA should be emphasized in order to prevent TIA relapse and the occurrence of irreversible changes

Notch signal pathway can regulate the morphogenesis,apoptosis and cellular proliferation of normal tissues and organs,which plays an important role in regulating hematopoietic cells proliferation and differentiation in bone marrow microenvironment.The occurrence and development of multiple myeloma(MM)are closely related to the bone marrow microenvironment in which many signal pathways are involved.Recent studies show that Notch signal pathway promotes the development and progression of many cancers including MM,which plays key roles in tumor invasion and drug resistance.This review focus on the recent findings on Notch signal pathway in MM,and reveals that Notch signal pathway will be identified as a potential new therapeutic target in MM.

Objective To explore the relationship between the activity of cholinesterase in hemolyzed blood sample and non-hemolyzed blood sample. Methods The activities of cholinesterase in hemolyzed blood samples and non-hernolyzed blood samples from 112 healthy individuals in Ji'nan were determined by the ferric trichloride chro-mometry, and the activities of cholinesterase in hemolyzed blood samples were adjusted by the concentration of ho-moglobulin (Hb) in blood samples. Results Highly significant correlation was found in the activities of cholinesterase between hemolyzed blood samples and non-hemolyzed blood samples (r = 0.728, F