Objective:To explore the executive function of neuroleptic -naive and short -term medicated onset schizophrenic patients.Methods:55 drug naive patients and 49 patients with schizophrenia medicated for one month and 60 normal controls were administered the Wisconsin Card Sorting Test(WCST) to study the executive function.Results:Compared with the controls,neuroleptic-naive patients and medicated patients showed higher level in the number of total trials,perseverant errors,random errors,the rate of error responses and the rate of random errors,while they showed lower level in the number of categories,correct trials and the rate of correct responses.There was no significant difference in WCST between the neuroleptic-naive patients and medicated patients.Conclusion:Neuroleptic-naive and short-term medicated onset patients with schizophrenia may have executive dysfunction.

Objective: To examine the reliability and validity of self-report scale of brief psychopathological symptoms(SBPS). Methods: The reliability and validity of the scale were tested based on three groups of subjects, including the cases involved forensic problems, the patients with mental disorders and normal persons. Some of them were retested 5-15 days after first examination. Other subjects of them finished MMPI at the same time. Results: ①The Cronbach's ? coefficients of SBPS was 0.91. The split-half reliability was 0.90. The test-retest reliability ranged from 0.73～0.98. ②The correlations between factors scores and the total scores ranged from 0.79 to 0.87. The correlations among the four factors scores, ranged from 0.50 to 0.65. Significant correlation was found between the total scores of SBPS and the fake scores of MMPI (r =0.76). Based on the experts diagnosis, the accuracy rate of SBPS for evaluating malingering was 86.6%. Conclusion: The SBPS has acceptable psychometrics properties on reliability and validity.

AIM: To evaluate the biological characteristics and differentiating potentials of bone marrow-derived mesenchymal stem cells(MSCs) from sensitized mice by allogeneic splenocyte transfusion in vitro.METHODS: Adherent culture method was applied for culturing the bone marrow-derived MSCs from sensitized mice.The cell morphology was examined and the surface marker profiles were analyzed by flow cytometry.The differentiating potentials of the MSCs into osteogenic,adipogenic and myogenic lineages were explored.The bone marrow-derived MSCs from the normal mice were collected and served as controls.RESULTS: Both the bone marrow-derived MSCs from sensitized and normal mice were exhibited a homogeneous distinctive morphology and were positive for the surface markers CD29,CD105,CD44 and Sca-1,negative in CD 34 and CD11b.The abilities of both MSCs to differentiate into osteogenic,adipogenic and myogenic pathways in the same condition were also observed.CONCLUSION: There is no difference in the biological characteristics and induced differentiating potentials between the sensitized mouse bone marrow-derived MSCs by allogeneic splenocytes transfusion and the MSCs from normal mice.

Objective The predictive value of the metabolic syndrome (MetS) for mortality from all-cause and cardiovascular disease (CVD) in the Chinese population is unclear. The aim of this present study was to compare MetS with its individual components as predictors of mortality in Chinese elderly adults. Methods A cohort of 1,535 subjects (994 men and 541 women) aged 50 years or older was selected from employees of a machinery factory in 1994 and followed until 2009. Cox models were used to estimate the hazard ratios (HRs) predicted by MetS according to the harmonized definition and by its individual components. Results The baseline prevalence of MetS was 28.0% in men and 48.4% in women. During a median follow-up of 15 years, 414 deaths occurred, of these, 153 participants died from CVD. Adjusted for age and gender, the HRs of mortality from all-cause and CVD in participants with MetS were 1.47 (95% confidence interval (CI): components. On evaluating the MetS components individually, we found that, independent of MetS, only hypertension and impaired glucose predicted higher mortality. Conclusions The number of positive MetS components seems no more informative than classifying (dichotomous) MetS for CVD risks assessment in this Chinese cohort.

Objective To examine the reliability and validity of the Rating Scale of the Reliability in Mental Disorder Medical History (RSRMDMH) in order to develop a reliable measure to determine the reliability in mental disorder medical history.Methods RSRMDMH was conducted by concept,clinical feature in mental disorder medical history and assessment scales for malingering and compensationneurosis.Final 14 items was decided after initial usage and modification.It was administered to 600 subjects including the cases involved forensic problems,patients in general psychiatric clinic.Results ①The Cronbach' s α coefficients of RSRMDMH was 0.901.The split-half reliability was 0.803-0.924.The test-retest reliability and scorer reliability were more than 0.588 (P＜0.01).②The cut score of assessing different degree of the reliability in mental disorder medical history separately was ≤ 11,12-22,≥23.③Based on the experts diagnosis,the accuracy rate of RSRMDMH for evaluating different degree of the reliability in mental disorder medical history were more than 86.1％,and total accuracy rate was 94.8％.④Correlation analysis showed significantly correlation between RSRMDMH and assessment scales for malingering(self-report scale of brief psychopathological symptoms,SBPS).Conclusion The RSRMDMH has acceptable psychometrics properties on reliability and validity.It is a clinically reliable measure to determine the reliability in mental disorder medical history.

Objective To investigate prevalence of long-term mental disorders following traumatic brain injury (TBI) in 4 ～ 13 years. Methods Of the 4287 patients with traumatic brain injury by systematic sampling.675 subjects were screened by the manual of the psychiatric consequences following traumatic brain injury. The final diagnoses of mental disorders were determined by two advanced psychiatrists based on CCMD-3 on the criteria of organic mental disorders. Results ① Of the 675 subjects with traumatic brain injury,206 had satisfied diagnosed criteria of one or more organic mental disorder syndromes by CCMD-3, and with dementia 17.48% , amnestic syndrome 1. 04% , personality or behaviour change 13. 84% , psychotic syndrome 1. 19% , depressive syndrome 7.41% ,manic syndrome 0.30% ,hysteric syndrome 0.98% , neurotic syndrome 10. 22%. ②The incidence of the mental disorders in the subjects with severe TBI was significantly higher than that of moderate and mild TBI,separately 66.01% (134/203) ,18.04% (46/255) and 11.98% (26/217 ),λ2 =109.03 and 129.82 separately(P< 0.01). ③The incidence of the personality or behaviour change in male was significantly higher than that of female, separately 15.31% and 6.98% (λ2 =5.65, P<0.05). The incidence of the neurotic syndrome in female was significantly higher than that of male, separately 15. 12% and 8. 55% (λ2 = 6. 02, P < 0.05). Conclusion The high incidence of the mental disorders in the patients with TBI should not neglect. There are more high occurrence rate with more severe degree of brain injuries.

Objective To examine the reliability and validity of compensative neurosis assessing scale (CNAS) and in order to develop the quantitative assessing method for distinguishing the compensation neurosis from malingering and typical neurosis. Methods The reliability and validity of the scale was tested based on the subjects including the cases involved forensic problems, the patients with typical neurosis in general psychiatric 0.944. The test-retest reliability was more than 0.820. The scorer reliability was more than 0. 812. The total accu-racy rate of CNAS for evaluating three groups of subjects based on the experts diagnosis, and with 91.2% of speci-ficity and 79.3% of sensitivity for evaluating compensation neurosis. Condusion The CNAS has acceptable psy-chometrics properties on reliability and validity. It will provide method to distinguish the compensation neurosis from malingering and typical neuroses.

Objective To test the cut-off point and empirical validity of psychiatric assessment scale of cognitive and volition capacity for suspects in crime (PASCVC).Methods One thousand of forensic psychiatry cases from fifteen bodies of the seven administrative regions in China were collected for forensic assessment by the three scales of PASCVC,DCRRS and CRRSV in August 2009 to December 201 l.in all cases by the appraiser to make six grade judgment of the cognitive and volition capacity including completely lost,lost most,partial loss,partial loss of a small,slightly damaged and normal.Results ① Based on the results of frequency distribution table: complete loss of demarcation divided ＜ 56 minutes,lost most 57-66,partial loss 67-76,partial loss of a small 77-87,slightly damaged 88-100 and normal ≥ 101.②The correlation coefficient of six demarcation point grading assessment results and expert opinion was 0.939(P＜0.001).③PASCVC consistency with DCRRS and CRRSV,the Kappa values were 0.838 and 0.835 respectively(P＜0.001).④Discriminant function were established by two methods of PASCVC and expert assessment,the correct rates of PASCVC and expert judgment on back substitution determine were 86.9％ and 85.1％.Two kinds of classification results,the Kappa value of 0.857 (P＜0.001).Conclusion PASCVC has good empirical validity,and can be used as an objective assessment tool for forensic assessment of criminal cognitive and volition capacity.

Objective To test reliability and validity on the scale of hurting factors participation for mental disorders (SHFP-MD).Methods 402 cases were retrospectively evaluated by SHFP-MD from 13 forensic psychiatric appraisal agencies in China,and all cases were involved causal relationships in mental injury from July 2010 to June 2012.42 cases were evaluated a month later again.13 raters evaluated respectively for five cases.52 cases involved causal relationship of mental impairment were evaluated prospectively in January 2013 to June 2014.The validity of the scale was tested by experts assessed as a criterion level of relationship.Results ①The retest correlation coefficient on all items of SHFP-MD were between 0.746-0.989,and the time reliability of test-retest on the full scale score was 0.970 interval of one month.Raters reliability between 0.57 to 1.00; overall average reliability was 0.84 (P＜0.01).②The total coincidence rate was 90.4％-91.0％ between the demarcation scores of SHFP-MD and the grade identification of forensic psychiatrists respectively and prospectively(P＞0.05).Conclusion SHFP-MD has good reliability and validity,and met the basic requirements of scale assessment.

OBJECTIVETo study the chemical constituents from the root barks of Morus atropurpurea.

METHODThe chemical constituents from the 70% ethanol extract of M. atropurpurea were isolated and purified by column chromatographic methods. Their structures were identified by physico-chemical properties as well as spectral data.

RESULTFifteen compounds were isolated and identified as sanggenol O(1), kuwanon S(2), moracin C(3), mulberrofuran A(4), mulberrofuran B(5), mulberrofuran C(6), mulberrofuran G(7), mulberroside A(8), mulberroside C(9), 1-deoxynojirimycin(10), 2-O-alpha-D-galactopyranosyl-1-deoxynojirimycin(11), fagomine(12), betulinic acid(13), ursolic acid(14) and beta-sitosterol(15).

CONCLUSIONCompounds 1-6 and 8-13 were isolated from M. atropurpurea for the first time.