1.The protective effect of ischemic preconditioning on pancreas transplantation in rats
Tingting HE ; Xiaonan LIU ; Weizhong WANG ; Kaizong LI ; Wenxian GUAN ; Dongl CHEN
Chinese Journal of General Surgery 1994;0(05):-
Objective To investigate the effect of ischemic preconditioning (IPC) on pancreas transplantation(PT) in rats. Methods Steptozozin-induced diabetic SD rats were randomly assigned to 2 groups: group I/R (ischemia/reperfusion), consisted of 30 diabetic rats which received PT; group IPC, consisted of 30 diabetic rats which received pancreas transplantation and IPC. Six rats in each group were randomly sacrificed at 2 days before PT, and 3 days and 7days after PT, to detect the level of blood sugar and amylase,and pancreatic sections were stained with HE simultaneously; 6 rats were used to observe various metabolic indexes , and other 6 rats were used to observe the rat survival rate. Results The rats of group IPC had a higher 1 month survival rate than group I/R (5/6 vs 3/6, P
2.Validation of the use of foreign gas rebreathing method for non-invasive determination of cardiac output in heart disease patients.
Liang DONG ; Jian-an WANG ; Chen-yang JIANG
Journal of Zhejiang University. Science. B 2005;6(12):1157-1162
OBJECTIVETo compare a new device (Innocor) for non-invasive measurement of cardiac output (CO) by foreign gas rebreathing method with conventional techniques used in the measurements of cardiac function.
METHODSCardiac outputs measured by Innocor (CO(RB)) were compared with CO obtained by echocardiography (CO(EC)), Swan-Ganz thermodilution (CO(TD)), and left ventricle radiography (CO(LVR)) in 34 patients subjected to cardiac catheterization. Values obtained from the four methods were analyzed by linear regression and paired values were compared by the method of Bland and Altman in SPSS.
RESULTSThere was strong positive correlation (r=0.94) between Innocor cardiac output values and the corresponding values obtained by thermodilution and between CO(EC) and CO(LVR) values. Thermodilution appears to overestimate cardiac output when compared to the values obtained with Innocor by (0.66+/-0.22) L/min (P<0.0001). There was no correlation between data obtained by Innocor and the corresponding CO(EC) and CO(LVR) values.
CONCLUSIONInnocor CO(RB) is an easy, safe and well established method for non-invasive measurement of cardiac output with good prospects for clinical application in heart disease patients.
Adult ; Aged ; Breath Tests ; methods ; Carbon Dioxide ; Cardiac Output ; Female ; Heart Diseases ; diagnosis ; physiopathology ; Heart Function Tests ; methods ; Humans ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity
Result Analysis
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