Objective To explore the effects of individualized nutrition intervention on body weight gaining and pregnant outcome in normal pregnant women. Methods Two hundred and twelve normal pregnant women admitted in our hospital before the 12th gestational week were divided into the observation group and the control group. Eighty-eight pregnant women admitted between October 2013 and January 2014 were assigned into the observation group and another 124 pregnant women admitted between June 2013 and September 2013 into the control group. The observation group was given nutrition assessment and nutritional guidance one by one and face to face by the nutritionist at three time points:around the 12 thgestational week, between the 22nd to 24th gestational week, and between the 32nd to 34th gestational week. The control group was given regular antenatal visits and lectures during pregnancy. These two groups were followed up until delivery. The comparisons were down between the groups in terms of body weight gain and complications during pregnancy, delivery mode and the change of perinatal fetus outcome. Results In the observation group, the body weight gaining of the pregnant women during pregnancy, the incidence of gestational diabetes mellitus (GDM) and the cesarean section rate were significantly lower than those of the control group (all P<0.05). The neonatal birth weight and the incidence of macrosomia were significantly lower than those of the control group (all P<0.05). Conclusion Individualized nutritional intervention given by the nutritionist can control body weight gaining during pregnancy, decrease the incidence of GDM, improve the pregnancy outcome and ensure the maternal and child health.