Objective:to do a population study with MMSE in rural area of north China.Method:13 962 farmers aged 55 or above from four villages in Linxian of Henan province were tested with MMSE, with 3 different cut-off points according to different level of education in our sample.Result:in our sample, the average total score of MMSE was lower than Chinese norm, especially that of calculation. Those aged, with poor education, female, with low SES had lower scores in MMSE test. There was a negative correlation between score of MMSE and that of ADL (acitivity of daily living).Conclusion:female, age, poor education, low SES are risk factors for dementia.

Objective:To obtain some effective objective markers used to predict the early liver metastasis of colorectal tumor,the relationship of liver metastasis of colorectal tumor with associate detection three markers such as CK20mRNA、CD44V6 and PCNA was studied. Methods:The expression of CK20mRNA in portal venous blood from 30 colorectal cancer patients was detected by fluorescent quarto RT-PCR,and the results of CD44V6 and PCNA in colorectal cancer tissue were determined by means of immunohistochemistry, and then compared with control groups through statistics analysis. Results:The rate of positive expression of CK20mRNA in colorectal cancer patients' portal venous blood was obviously superior to the level of benign pathological changes controls(P