1.Effect of danazol on rat ectopic endometrium.
Hui ZHENG ; Hong-yi LI ; Jun DONG
Chinese Journal of Applied Physiology 2005;21(1):67-68
Animals
;
Danazol
;
pharmacology
;
Endometriosis
;
drug therapy
;
Endometrium
;
drug effects
;
Female
;
Interleukin-6
;
metabolism
;
RNA, Messenger
;
genetics
;
Rats
;
Rats, Sprague-Dawley
2.A retrospective analysis of estimating postmortem interval in 256 murder cases.
Zheng SUN ; Li-Hui ZHONG ; Dong SUN
Journal of Forensic Medicine 2013;29(6):434-436
OBJECTIVE:
To discuss the method of reducing error in estimating postmortem interval (PMI).
METHODS:
Two hundred and fifty-six solved murder cases from 2003 January to 2013 January in Changzhou and Nanjing City were collected, The PMI of all cases was estimated by traditional method and then compared with the real PMI obtained after the cases were solved. The cases were grouped according to the PMI, the accuracy was calculated, and the reasons of suboptimal PMI were analyzed.
RESULTS:
The accuracies of early PMI (less than 12h and 13-24 h) were 90% and 89%, respectively; while the accuracies of late PMI (1-7 d, 1-2 weeks, 3-4 weeks, 1-6 months, 7-12 months and 1-5 years) decreased over time, being 79%, 76%, 83%, 79%, 60% and 50%, respectively. The common reasons of estimating error included improper inference methods, water submerged body, extreme temperature, lack of objective evidence, intentionally abandoned body, and changed or destroyed scene, etc.
CONCLUSION
The multiple index data can reduce the error in estimating PMI.
Autopsy
;
Cause of Death
;
Forensic Pathology/methods*
;
Homicide
;
Humans
;
Postmortem Changes
;
Retrospective Studies
;
Seasons
;
Temperature
;
Time Factors
3.Design of Non-Invasive Blood Oxygen Measurement Based on AFE4490.
Jinsong ZHU ; Shouhao WU ; Wenxiu GUO ; Hui ZHENG ; Dong TANG
Chinese Journal of Medical Instrumentation 2015;39(5):341-343
From the perspective of portable monitoring devices,we use an analog front-end AFE4490 design a module of Non-invasive blood oxygen measurement, used to collect human pulse wave signal and peak (valley) value detection and then use the principles of non-invasive oximetry calculated oxygen saturation (SPO2). This design of noninvasive oximetry module has the characteristics of small size, low power consumption, and the results of test show that the measurement of oxygen saturation are correct.
Heart Rate
;
Humans
;
Oximetry
;
instrumentation
;
methods
;
Oxygen
;
blood
5.Pathologic features of BRCA-associated ovarian carcinoma.
Chinese Journal of Pathology 2013;42(12):846-850
Age of Onset
;
Cystadenocarcinoma, Serous
;
genetics
;
metabolism
;
pathology
;
Female
;
Genes, BRCA1
;
Genes, BRCA2
;
Humans
;
Immunohistochemistry
;
Neoplasm Staging
;
Ovarian Neoplasms
;
genetics
;
metabolism
;
pathology
;
Receptors, Progesterone
;
metabolism
;
Tumor Suppressor Protein p53
;
metabolism
6.Recent advances on ovarian epithelial cancer: definition, subtypes and pathologic features.
Chinese Journal of Pathology 2013;42(9):624-628
Adenocarcinoma, Clear Cell
;
metabolism
;
pathology
;
Adenocarcinoma, Mucinous
;
metabolism
;
pathology
;
Carcinoma, Endometrioid
;
metabolism
;
pathology
;
Carcinoma, Transitional Cell
;
metabolism
;
pathology
;
Cystadenocarcinoma, Serous
;
metabolism
;
pathology
;
Diagnosis, Differential
;
Female
;
Humans
;
Neoplasms, Glandular and Epithelial
;
classification
;
metabolism
;
pathology
;
Ovarian Neoplasms
;
classification
;
metabolism
;
pathology
;
Tumor Suppressor Protein p53
;
metabolism
;
WT1 Proteins
;
metabolism
7.Modified Stoppa approach in treatment of bilateral pubic branch fractures.
Zheng-feng MEI ; Wen-tao LEI ; Dong-hui HUANG ; Qi-hui ZHAO ; Feng-dong ZHAO ; Shun-wu FAN
China Journal of Orthopaedics and Traumatology 2015;28(5):404-407
OBJECTIVETo investigate the feasibility and effectiveness of modified Stoppa approach in treatment of bilateral pubic fractures of pelvic.
METHODSThe therapeutic effects of 16 patients with bilateral pubic fractures treated through the modified Stoppa approach from January 2010 to January 2014 were summarized and analyzed, involved 11 males and 5 females with an average age of 40.5 years old ranging from 17 to 59 years. According to Tile classification, there were 8 patients with type A, 6 with type B and 2 with type C. For 16 pelvic fractures, the modified Stoppa approach was used exclusively 11 cases, in combination with the iliac fossa approach in 4 cases, and in combination with the posterior approach in 1 case. The operation incision length, operation time , intra-operative blood loss and postoperative complications were observed. The fracture reduction and post-operative function were assessed by Matta criteria and Majeed system respectively.
RESULTSThe incision length of the modified Stoppa approach ranged from 8 to 10 cm (averaged in 9 cm). The operation time ranged from 75 to 135 minutes (averaged in 95 minutes). The intra-operative blood loss ranged from 400 to 900 ml (averaged in 600 ml). Sixteen patients were followed up from 7 to 18 months (averaged in 12.5 months). The fractures were all healed, the fracture healing time was 2.7 to 5 months (means 3.1 months). There were no infections, ectopic ossification, screw loosening, plate breakage and lateral ventral syndrome. According to Matta criteria for pubic fracture reduction, the result was excellent in 9 cases, good in 6, fair in 1. The Majeed function scores at 6 months after operation was 85.32±8.50; the result was excellent in 8 cases, good in 6 cases, fair in 2 cases.
CONCLUSIONThe modified Stoppa approach has characteristics of convenience and directness of incisions, clear operation field, easy reduction, few complications and fast recovery , it is an ideal choice in surgical treatment of bilateral pubic fractures.
Adolescent ; Adult ; Bone Plates ; Female ; Follow-Up Studies ; Fracture Fixation, Internal ; Fractures, Bone ; surgery ; Humans ; Male ; Middle Aged ; Operative Time ; Orthopedics ; methods ; Pubic Bone ; injuries ; surgery ; Young Adult
8.Performance test and evaluation on Halcyon medical linear accelerator
PENG Jun zhe ZHAI He zheng CHEN Dong hui ZHAI Zi po LONG Hui jia CHENG Yan meng
China Occupational Medicine 2022;52(04):458-
Abstract: Objective
To evaluate the key quality control and protective performance test of Halcyon medical linear accelerator.
Methods WS 674-2020Specification for Testing of Quality Control in Medical Linear Accelerator(
According to the hereinafter
WS 674-2020) ,
referred to and the manufacturer´s manual the performance of the first Halcyon medical linear accelerator in
Results , ,
Hunan Province was tested. The results showed that all ten indicators of the accelerator including dose deviation
, , ( , , , -
repeatability linearity daily stability and symmetry the results were 0.10% 0.03% 0.04% 0.50% and 100.50% 100.80%
), - -
respectively met the requirements of WS 674 2020. The results of manufacturer quality control indicators such as dose rate
, ,
stability in beam gantry rotation isocenter and mechanical position accuracy megavolt image parameters and cone beam
computer tomography image parameters met the requirements of the manufacturer´s regulations. Due to the special structure and
, - :
function of the accelerator it is difficult to detect the parameter required by WS 674 2020 as below the radiation leakage
- , , , ,
outside the M zone the uniformity the indicators related to the light field the offset of the radiation beam axis the zero scale
Conclusion -
position of the rotating motion scale and others. It is difficult to carry out complete testing according to WS 6742020
for Halcyon medical linear accelerator and it is urgent for the state to issue relevant testing standards to standardize and
strengthen the quality control testing of various accelerators.
9.Experimental study on treatment of endometriosis with xiaochaihu decoction.
Chinese Journal of Integrated Traditional and Western Medicine 2006;26 Suppl():119-122
OBJECTIVETo explore the effect of Xiaochaihu Decoction (XCHD) on ectopic endometrium in rats with endometriosis and its mechanism.
METHODSThe rat model of endometriosis was established and rats were divided into 5 groups, the low dosage of XCHD group (5 g x kg(-1) x d(-1) , n = 10) , the medium dosage of XCHD group (10 g x kg(-1) x d(-1), n =10), the high dosage of XCHD group (15 g x kg(-1) x d(-1), n = 10) , the danazol group(0. 1 g x kg(-1) x d(-1), n =9) and the control group(20 ml x kg(-1) x d(-1) distilled water, n = 10). After treated for four successive weeks, the effect of XCHD on ectopic endometrium was evaluated by observing the changes in transmission electron microscopy. Fas and Caspase-3 protein expression in endometrium and endometriotic tissue were observed by immunohistochemistry method.
RESULTSEctopic endometrial growth was markedly inhibited (P < 0. 05 or P < 0. 01) in all the XCHD groups; Fas and Caspase-3 protein expressions of ectopic endometrial tissue were higher than those in the endometrium.
CONCLUSIONXCHD could inhibit the growth of the ectopic endometrium in rats with experimentally induced endometriosis. The therapeutic mechanism may be related to promoting the apoptosis in ectopic endometrial tissue by increasing Fas protein expression.
Animals ; Caspase 3 ; metabolism ; Drugs, Chinese Herbal ; administration & dosage ; pharmacology ; therapeutic use ; Endometriosis ; drug therapy ; immunology ; Endometrium ; drug effects ; metabolism ; Female ; Rats ; fas Receptor ; metabolism
10.Clinical study of a rare case of primary central nervous system natural killer/T cell meningeal lymphoma
Zheng LIU ; Wenjun CHEN ; Hongzhi GUAN ; Haitao REN ; Hui WANG ; Huiqing DONG ; Jianping JIA
Chinese Journal of Neurology 2011;44(2):81-85
Objective To explore the clinical features and diagnostic method of primary natural killer( NK)/T cell meningeal lymphoma. Methods An unusual case of a 19-year-old male with primary NK/T cell meningeal lymphoma was reported. His clinical presentation and laboratory findings were discussed. The related literatures have been reviewed. Results The patient presented with diplopia,headache, vomiting and facial drooping at the onset, followed by progressive pain and weakness of the four limbs. Cerebrospinal fluid showed significant increase in pressure, leukocytes number, levels of protein,normal glucose and adenosine deaminase, negative tuberculosis antibody and sterile staining. In cerebrospinal fluid cytological analysis, May-Grunwald-Gimsa staining showed large number of atypical lymphocytes with irregular nucleus and nuclear fission, Ki-67 immunostaining showed extensive proliferative activity of the lymphoid cells. Flow cytometric immunophenotypic analysis of cerebrospinal fluid indicated 97. 98 percent of cells expressed surface CD3, CD7, CD56, CD2, CD5, and partially expressed CD8. This was a rare immunophenotype for NK/T-cell. Cranial MRI with gadolinium showed thickening of the trigeminal nerve with slight enhancement and diffuse leptomeningeal enhancement. CT of the chest and abdomen and bone marrow biopsies were negative. He was diagnosed as primary NK/T cell meningeal lymphoma based on the clinical features and related examination. Conclusions Primary NK/T cell meningeal lymphoma is a rare type of primary central nervous lymphomas which has special immunophenotype. The clinical features include progressive raised intra-cranial pressure, multiple cranial and spinal nerve involvements. Cerebrospinal fluid cytological analysis and flow cytometric immunophenotypic analysis are key work-up for diagnosis. It has poor response to chemotherapy and radiotherapy.