Objective:To study the value of measurement of serum TRAb levels in diagnosis and treatment of patients with thyroid disease.Methods:The levels of serum TRAb(by RRA),FT 3?FT 4 and titrations of TGAb,TPOAb(by RIA) were measured in 308 patients with thyroid disease as well as in 50 normal people.Results:The average levels and positive rates of serum TRAb were significantly higher in patients with Graves' disease (including hypertyroid group and remission group) and Hashimoto's disease than those in normal group,and the hypertyroid group were significant higher than the remission group in level and positive rate of TRAb.There were no correlations between serum TRAb levels and FT3,FT4 levels in patients with Graves' disease,and titrations of TGAb,TPOAb in patients with Hashimoto's disease.Conclusion:Serum TRAb level can not reflect the severity of Graves' disease,and TRAb is another auto-antibody different from TGAb,TPOAb,but there is important value in determing the serum TRAb level in diagnosis and treatment of auto-immune thyoid disease,especially to Graves' disease.

Objective:To evaluate of the application of 99m Tc-EGFR-McAb to radioimmunoimaging for nude mice bearing lung adenocarcinoma and do correlation analysis.Methods:① The model of nude mice bearing lung adenocarcinoma was established;②The direct labeling method of 99mTc was applied to labele monoclonal antibodies for EGFR,and then the properties of the labeling antibodies were identified;③Radioimmunoimage and radioactivity distribution with 99mTc-EGFR-McAb on the animal model of nude mice bearing lung adenocarcinoma were studied.Results:The labeling rates of 99mTc for EGFR-McAb was 91.5% ?3.8%.Specific activity of the labeled antibody was(2.8?0.2)MBq/?g,and the radiochemical purity was 96.5%?3.2%.The tumor had high intake of the labeled antibodies according to radioimmunoimaging result.The T/NT relative value measured through ROI technique was 2.74?0.5,which was significantly higher than that of the control group(P

Objective:To evaluate the clinical value of 99Tcm-MIBI double-phase imaging on anatomical diagnosis of primary hyperparathyroidism(PHPT).Methods:Double phase 99Tcm-MIBI imaging was performed in 15 normal controls and 51 patients with primary hyperparathyroidism proven by physical examination and biochemical blood tests(for the latter group,the examination was performed in 1 week before the operation).Tomographic scanner was arranged for part of the patients.The uptake ratio was calculated and compared by ROI sequence.Results:Comparing the imaging results with those of histopathology,the sensitivity percentages of early and delayed phases to parathyroid adenomas were 78.3%(36/46)and 91.3%(42/46),and those to parathyroid hyperplasia were 23.8%(5/21)and 47.6%(10/21)respectively.Six lesions of parathyroid were demonstrated by SPECT tomographic imaging.The positive rate of lesions(weighting between 500 to 1500 mg)was 82.4%,and all lesions over 1500 mg appeared to be positive,those less than 500mg appeared to be negative in 99Tcm-MIBI double-phase imaging.For positive parathyroid adenoma group,the uptake ratio of delayed phase was significant higher than that of early phase(P

Objective:To evaluate the clinical value of radionuclide imaging with ~(131)I-MIBG in the diagnosis of adrenal medullary lesions.Methods:The ~(131)I-MIBG adrenal medullary imaging results of 48 patients(12 with primary hypertension as control group,21 with pheochromocytoma,and 15 with adrenal medullary hyperplasia)were analyzed and compared with those of CT and B ultrasonography.The uptake ratio of adrenal gland to background and to myocardium were calculated and compared by ROI sequence.Results:In ~(131)I-MIBG imaging,for the patients with pheochromocytoma,11 of them were found abnormal radioac- tive increase of one adrenal gland;2 ectopic pheochromocytoma were demonstrated;3 were found with multiple abnormal ra- dioactive increase in the whole body besides adrenal gland were demonstrated with malignant pheochromoeytoma;one adrenal gland was shown clearly of 3 patients and 2 patients appeared negative,with the positive rate of 90.5%.Of the patients with adrenal medullary hyperplasia,8 were found with one adrenal gland imaging and 3 with two adrenal gland imaging;4 patients appeared with negative,with the positive rate of 73.3%.The uptake ratio(obtained by ROI sequence)in pheochromocytoma and hyperplasia group were remarkably higher than that in control group,of which pheochromocytoma group was remarkably higher than hyperplasia group.Conclusion:~(131)I-MIBG imaging is an effective tool in the localizing and qualitative diagnosis of adrenal medullary lesions.ROI sequence can increase the positive rate and benefit the differential diagnosis.

ObjectiveTo explore pathogenesis of headache after subarachnoid hemorrhage (SAH) whether related with immune inflammatory reaction in subarachnoid and observe the effect of immunosuppressive action of dexamethasone on headache.Methods80 patients who was consciousness and complained headache after SAH were randomly divided into four groups, treated only with mannitol, mannitol plus cerebrospinal fluid (CSF) replacement, intrathecal and vein injection with dexamethasone. Effects of four groups were observed.ResultsEfficiencies of four groups were respectively the mannitol group 27.27%, the permutation group 66.67%, the intrathecal group 92.36% and the vein group 30.00%. There was a significantly difference between the intrathecal group and other three groups, and the time of headache remission for intrathecal group was also longer than that of other three groups (P<0.01).ConclusionThe wide immune inflammatory responses in subarachnoid induced by degenerative and hemic CSF is likely main cause of headache after SAH and intrathecal injection with dexamethasone has an obviously effect.

Endothelium, Vascular ; cytology ; Humans ; Mucocutaneous Lymph Node Syndrome ; complications ; pathology ; Neovascularization, Pathologic ; Stem Cells ; cytology

Objective To observe the influence of diabetes educationon the treatment compliance and quality of life (QOL) of diabetics and to find out the influencing factors of diabetics' QOL. Methods This study applied the questionnaire of compliance and the SF-36 to make an investigation on diabetics. Ninety diabetics who participated in the course of diabetes education during the period from October 2008 to March 2009, and 205 diabetics who were seen in the first affiliated hospital of China Medical Universitybut never participated in the course of diabetes education during the period from September to October of 2008. By comparing the data with control group and using self-paired comparison, the influence of diabetes education on the treatment compliance and the QOL of diabetics was studied. The factors influencing the QOL of each dimension were analyzed by means of single or multiple regressions. Results The treatment compliance of patients was improved with the number of times that these patients participated diabetes education was increased (P<0.05). The treatment compliance of the patients in hospital who had not participated in diabetes education was improved temporarily. However, 2 weeks after these patients were discharged the treatment compliance of these patients had began to decline. The treatment compliance would be declined if patients discontinued participating education for a long time. After 24 weeks intevention, the total score of compliance of intervention group (42.44±4.10) was higher than control group (35.60±3.90), and also higher than the intervention group before intervention (34.56 ± 4.34) (all P<0.01). The scores of 5 dimensions were significantly different (P<0.05 or 0.01). Of 8 dimensions of intervention group, the scores of vitality, social functioning, role-emotional and mental health were all increased after intervention, with significant differences except for role-emotional (P<0.05). The mental health index of patients with long-term health education was increased to a certain degree. Conclusion Long-term health education plays an active role in treatment. Insisting on taking part in health education regularly can improve the quantity of mental health.

The enrollment of foreign medical students has expanded year after year.The education of foreign students becomes an important part of college education.In order to explore an effective method of medical education,the difference between Chinese students and foreign ones has been analyzed and the experience has been concluded according to the practice in teaching clinical diagnostics in recent years.