1.Studies on effect of artemether to control infection and prevent acute infection of Schistosoma japonicum in high endemic areas
Honggen CHEN ; Dandan LIN ; Yuesheng LI ; Yuemin LIU ; Donald P. Mcmanus ; Xinghua HUANG ; Zheng FENG ;
Chinese Journal of Schistosomiasis Control 1989;0(01):-
Objective To observe the effect of artemether in the control of prevalence and acute infection of Schistosoma japonicum in humans in high endemic areas. Methods During the transmission season (May-October), the residents in the pilot village took artemether with a 15- day interval to prevent the infection of S. japonicum. Results By the end of the transmission season, the egg positive rate was 0.83% and no acute case occurred in the artemether group, while 15.01% and 3 acute cases were observed in the placebo group. Conclusions Oral administration of artemether at a 15-day interval shows an effective protection from infection of S. japonicum, with a protection rate of 94.47% in residents of a high endemic area and it also shows marked effect to prevent acute schistosomiasis.
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