The authors used immunohistochemistry and in situ hybridization to observe the expression of the p16 and Rb mRNA and protein levels in 89 cases of lung cancer. The results showed that the loss of p16 gene expression took place mainly in non small cell lung cancer, and loss of Rb gene expression mainly in small cell lung cancer. The expression of these genes on protein level fundamentally corresponded with mRNA level. It is suggested that the expression of these two genes are related to the histological type of lung cancer, and the p16 and Rb genes can be considered as one of molecular biological targets for gene classification diagnosis. There may exist a mechanism at gene translation level which leads to the inactivation of the p16 and Rb genes.

Mesenteric lymphadenitis due to Yersinia enterocolitica infection is not common in Korea. Although most cases of Yersinia enterocolitica-induced mesenteric adenitis are self limited, cardinal features of Yersinia enterocolitica-induced mesenteric adenitis are so similar to those of acute appendicitis that some of the patients undergo laparotomy with suspected appendicitis. The findings on laparotomy in such patients are usually enlarged mesenteric nodes with a normal or slightly inflamed appendix. Because histologic examination of the removed mesenteric lymph nodes reveals reactive hyperplasia in most cases, it is usually difficult to suspect Yersinia enterocolitica infection on morphology of the resected nodes. But suppurative granulomata of mesenteric lymph nodes, uncommonly encountered in Yersinia enterocolitica infection, strongly suggest yersinial infection. We report a case of mesenteric lymphadenitis in a 10-year-old boy, who underwent laparotomy with suspected acute appendicitis. The removed lymph node showed several suppurative granulomata in the cortex, suggesting yersinial infection. Serologic study confirmed Yersinia enterocolitica serotype O:3 infection.
Appendicitis ; Appendix ; Child ; Humans ; Hyperplasia ; Korea ; Laparotomy ; Lymph Nodes ; Lymphadenitis ; Male ; Mesenteric Lymphadenitis* ; Yemen ; Yersinia enterocolitica* ; Yersinia*

The antihypertensive effect of nicardipine was studied in 31 cases of essential hypertension and following results were obtained. 1) Daily dose was 30-60mg for 10 weeks. 2) Mean systolic and diastolic pressure were decreased by 39.5mmHg 921%) and 17.2mmHg(15%) respectively(P<0.005) and in 84% of cases, good or fair control of blood pressure was proved. 3) There was no significant change in heart rates before and after treatment. 4) There were no significant side effects except two cases of mild headache and facial flushing which subsided spontaneously.
Blood Pressure ; Flushing ; Headache ; Heart Rate ; Hypertension ; Nicardipine*

Diabetes mellitus is known to be associated with a specific cardiomyopathy. This is evident from the clinical-pathological work and the epidemiologic data. An investigation was made in this study to determine whether diabetic cardiomyopathy in rats is associated with an alteration of biochemical characteristics of cardiac contractile proteins. Rats were made diabetic with intravenous injection of streptozotocin and hearts removed 8 weeks later for the isolation of myofibrils. The basal ATPase activity of myofibrils from diabetic hearts was significantly lower than that of the controls, suggesting the presence of some subtle structural and conformational changes in diabetic myofibrils. The activating effect of Mg ions on the myofibrillar actomyosin system of rat heart muscle was also demonstrated. Sodium dodecylsulfate gel electrophoresis showed the presence of myosin heavy chain, light chain 1 and 2, actin and troponin but failed to reveal differences in the patterns of these contractile proteins of light subunits between diabetics and controls. The deficiency in utilization of energy rich phosphates by the myofibrillar protein may be one of of the main mechanisms of cardiodepression observed in diabetic hearts. The cardiac myofibrillar ATPase activity may be one of useful measurements in evaluating pathophysiological states of cardiac contractile proteins.
Actins ; Actomyosin ; Adenosine Triphosphatases* ; Animals ; Cardiomyopathies ; Contractile Proteins ; Diabetes Mellitus ; Diabetic Cardiomyopathies ; Electrophoresis ; Heart ; Injections, Intravenous ; Ions ; Myocardium ; Myofibrils ; Myosin Heavy Chains ; Phosphates ; Rats* ; Sodium ; Streptozocin ; Troponin

The effects of KCI continus tablet(K-Contin(R)) on the serum level of K and uric acid during hydrochlorothizide therapy(25mg/day) were evaluated in 30 patients with essential hypertensien. The results are as follows : 1) During hydrochlorothiazide therapy(25mg/day), 23% of all patients showed hypopotassemia(<3.5mEq/1) while no patient developed hypopotassemia after potassium supplement therapy(8 mEq/day). 2) During the period of K supplement, the level of serum uric acid showed less elevation. 3) The side reaction of KCI continus tablet were mild indigestion which developed in two patients and disappeared soon without any particular treatment. In conclusion, the KCI continus tablet is useful in the prevention of hypopotassemia during chronic diuretic therapy.
Dyspepsia ; Humans ; Hydrochlorothiazide ; Hypokalemia ; Potassium ; Uric Acid*

Objective To investigate the activation, distribution, origin, and expression of hepatic stem cells(HSC)in different histological types of primary liver carcinomas. Methods The histological and immunohistochemical features of 94 cases of hepatocellular carcinoma (HCC), 12 cases of intrahepatic cholangiocarcinoma (ICC) and 10 cases of mixed hepatocarcinoma were examined by HE staining and immunohistochemistry SP method, with 5 cases of sclerotic liver and 4 cases of normal liver tissues as control. Results HSC expression was observed and the transfor mation from HSC to carcinoma cell was also noted in the liver. CK7, CK19, c-kit, Thy-1, and AFP were found expressed in different types of hepatic carcinomas and the greatest intensive expression was found in the mixed hepatocarcinoma (P

We present a case of dermatomyositis associated with small cell lung cancer. This 45-year-old male patient who had been diagnosed as small cell lung cancer presented multiple itchy violaceous patches, muscle weakness, myalgia and abnormal laboratory data. The skin lesions and myalgia were improved after treatment with dexamethasone 10mg/day under the diagnosis of dermatomyositis. The skin symptoms and myalgia were wax-and-waned despite of the improvement of lung cancer. Interestingly, telangiectasias observed on the proximal nail folds were wax-and-waned according to the skin and muscle symptoms, too. Further evaluation on the finding would be beneficial in the prognosis evaluation for the patients.
Capillaries* ; Dermatomyositis* ; Dexamethasone ; Diagnosis ; Humans ; Lung Neoplasms ; Male ; Middle Aged ; Muscle Weakness ; Myalgia ; Prognosis ; Skin ; Small Cell Lung Carcinoma* ; Telangiectasis

BACKGROUND: This prospective and cross-sectional study was conducted to assess the risk factors for coronary artery disease in the selected Korean Pateints. METHOD: We analyzed clinical parameters and biochemical parameters in 158 subjects; 98 subjects with significant coronary artery disease as proven by coronary angiography(stable angina pectoris : 55, unstable angina pectoris : 30, post-myocardial infarction angina pectoris : 13) and 58 normal subjects as proven by coronary angiography, from November 1993 to April 1994 in Seoul National University Hospital. RESULTS: 1) Old age, male gender, history of diabetes and smoking, high low density lipoprotein cholesterol level, high lipoprotein (a) level and high fibrinogen level were identified and risk factors for coronary artery disease on simple logistic regression analysis. 2) Lp(a) was positively related to fibrinogen(r=0.23), cholesterol(r=0.23) and low density lipoprotein cholesterol(r=0.28). 3) High fibrinogen level, old age, and male gender were independent risk factors of significant coronary artery disease in the selected Korean Population on multiple stepwise logistic regression analysis. CONCLUSION: High fibrinogen level, old age, and male gender six were independent risk factors of significant coronary artery disease in the selected Korean Population of multiple stepwise logistic regression analysis. These findings could not deny the role of cholesterol in coronary artery disease, but suggested that factors related to thrombosis and fibrinolysis, may play more important role in Korean patients coronary artery disease.
Angina Pectoris ; Angina, Unstable ; Cholesterol ; Cholesterol, LDL ; Coronary Angiography ; Coronary Artery Disease* ; Coronary Vessels* ; Cross-Sectional Studies ; Fibrinogen* ; Fibrinolysis ; Humans ; Infarction ; Lipoprotein(a) ; Lipoproteins ; Logistic Models ; Male ; Prospective Studies ; Risk Factors* ; Seoul ; Smoke ; Smoking ; Thrombosis

BACKGROUND: This prospective and cross-sectional study was conducted to assess the risk factors for coronary artery disease in the selected Korean Pateints. METHOD: We analyzed clinical parameters and biochemical parameters in 158 subjects; 98 subjects with significant coronary artery disease as proven by coronary angiography(stable angina pectoris : 55, unstable angina pectoris : 30, post-myocardial infarction angina pectoris : 13) and 58 normal subjects as proven by coronary angiography, from November 1993 to April 1994 in Seoul National University Hospital. RESULTS: 1) Old age, male gender, history of diabetes and smoking, high low density lipoprotein cholesterol level, high lipoprotein (a) level and high fibrinogen level were identified and risk factors for coronary artery disease on simple logistic regression analysis. 2) Lp(a) was positively related to fibrinogen(r=0.23), cholesterol(r=0.23) and low density lipoprotein cholesterol(r=0.28). 3) High fibrinogen level, old age, and male gender were independent risk factors of significant coronary artery disease in the selected Korean Population on multiple stepwise logistic regression analysis. CONCLUSION: High fibrinogen level, old age, and male gender six were independent risk factors of significant coronary artery disease in the selected Korean Population of multiple stepwise logistic regression analysis. These findings could not deny the role of cholesterol in coronary artery disease, but suggested that factors related to thrombosis and fibrinolysis, may play more important role in Korean patients coronary artery disease.
Angina Pectoris ; Angina, Unstable ; Cholesterol ; Cholesterol, LDL ; Coronary Angiography ; Coronary Artery Disease* ; Coronary Vessels* ; Cross-Sectional Studies ; Fibrinogen* ; Fibrinolysis ; Humans ; Infarction ; Lipoprotein(a) ; Lipoproteins ; Logistic Models ; Male ; Prospective Studies ; Risk Factors* ; Seoul ; Smoke ; Smoking ; Thrombosis

Aortic dissection is clinically suspected from the typical symptoms and signs and may be confirmed by computed tomography or aortography. But atypical presentations can be seen in a minority of cases, such as SVC syndrome, right pulmonary artery stenosis etc. We present a case which was initially suspected to be a right atrial tumor because of a large filling defect in the right atrium on radionuclide angiocardiography but finally confirmed to be dissection of ascending aorta by computed tomography.
Angiocardiography ; Aorta ; Aortography ; Constriction, Pathologic ; Heart Atria ; Pulmonary Artery