Background and Objective: Pseudomonas meningitis is a rare complication following neurosurgical procedures and is associated with high mortality and mortality. The aim of the study was to describe the clinical characteristics and risk factors associated with mortality in patients who developed nosocomial Pseudomonas meningitis following neurosurgical procedure. Methods: All patients with nosocomial post-surgical meningitis due to Pseudomonas aeruginosa diagnosed in the year were reviewed retrospectively. Results: During the period of the study, 121 cases of post surgical meningitis were diagnosed. Ten (9.9%) nosocomial Pseudomonas meningitis were identifi ed. Eight patients had external ventricular drain. The antibiotic susceptibility of 10 strains was: imipenem (9/10), meropenem (7/10), amikacin (7/10), piperacillin / tazobactum (5/10), ceftrizxone (4/10), cefepime (3/10). The overall mortality was high at 80%, despite most receiving appropriate antibiotics. Conclusion: Postoperative Pseudomonas meningitis is associated with high mortality.