No abstract available.
Dinoprostone*

Objective: To compare the efficacy of Dinoprostone gel versus intravaginal evening primrose oil capsule as cervical ripening agents for operative hysteroscopy…. and to compare the length of time to achieve a 10mm cervical dilatation prior to operative hysteroscopy. Methods: This is a two-arm randomized controlled trial done in a tertiary training institution. Group A and B received Dinoprostone gel and EPO for cervical ripening, respectively. Population consisted of women admitted for operative hysteroscopy, aged between 19-56 years old, and with closed cervix. Results: Thirty-eight (38) patients mostly pre-menopausal with mean age of 41, without history of uterine surgery, and presented with abnormal uterine bleeding, were included. Significant difference was observed in initial cervical dilatation between Dinoprostone gel(5.63 mm) versus EPO(4.21mm). Most patients in EPO group were pain-free while Dinoprostone group experienced tolerable pain. Use of Dinoprostone was 4x more expensive versus EPO. Conclusion Both agents were effective in dilating the cervix prior to operative hysteroscopy. Nevertheless, EPO may be superior and acceptable due to reduced cost, patient convenience and acceptability, and ease of administration.
Dinoprostone

No abstract available.
Dinoprostone* ; Suppositories*

No abstract available.
Amnion* ; Dinoprostone*

PURPOSE: The purpose of this study was to observe the effect of IFN- and PGE2 on TNF- production by human peripheral mononuclear cells(PBMC) that were stimulated with LPS. METHODS: PBMC were separated by Ficoll-Hypaque gradient centrifugation from human peripheral venous blood and were incubated for 72 hours with or without LPS, IFN- , PGE2, and indomethacin according to various conditions. TNF- activity of PBMC culture supernatants was assayed by determining the cytotoxicity against L929 cells. RESULTS: 1) The production of TNF- by PBMC in response to LPS reached the highest level between 8-24 hours and returned to control level by 72 hours. 2) When IFN- was added together with LPS, LPS-induced TNF- production was enhanced and prolonged, which was more remarkable when IFN- was added at higher concentration or earlier than LPS. 3) When PGE2 was added together with LPS, LPS-induced TNF- production was suppressed. 4) The addition of IFN-gamma reduced the suppressive effect of PGE2 on LPS-induced TNF- production. 5) Enough amount of indomethacin enhanced production of TNF- by LPS. CONCLUSIONS: IFN-gamma increased and PGE2 decreased the production of TNF- by PBMC which were stimulated with LPS. And PBMC which were pretreated with IFN-gamma were resistent to the suppressive effect of PGE2.
Centrifugation ; Dinoprostone* ; Humans* ; Indomethacin

No abstract available.
Dinoprostone* ; Membranes* ; Rupture* ; Suppositories*

No abstract available.
Amnion* ; Dinoprostone* ; Humans* ; Metabolism*

Background: A prolonged interval from prelabor rupture of membranes to delivery is associated with an increase in the incidence of maternal and neonatal morbidities and mortality. Various agents have been tested to improve the cervical Bishop score to expedite the delivery of the fetus and lessen the maternal and neonatal complications. Objective: To compare two protocols for labor induction in pregnant women with prelabor rupture of membranes (PROM). Population: Subjects were recruited from the University of Santo Tomas Hospital (Private Division and Clinical Division). Pregnant women with a live, term, singleton fetus, cephalic presentation, a reactive Non stress test, who presented with PROM and a Bishop score of ?5, with no previous Cesarean section, or other uterine surgery. Methodology: This is a two-arm superiority, open label, randomized controlled trial. Pregnant women with a live, term, singleton fetus, cephalic presentation, a reactive Non stress test, who presented with PROM and a Bishop score of ?5, and with no previous Cesarean section or other uterine surgery were randomly assigned to receive either intravenous (IV) oxytocin infusion or intracervical dinoprostone 0.5 mg gel followed 6 hours later by IV oxytocin infusion. Results: Vaginal delivery within 24 hours of labor induction increased significantly with intracervical dinoprostone gel followed by IV oxytocin infusion (87% versus 61%; RR: 1.43; 95% CI: 0.99 – 2.06; P<0.044). Comparable result was observed for nulliparous women included in the study population. The time interval from labor induction to active phase was significantly shorter in the dinoprostone-oxytocin group than in the oxytocin alone group (2.4 ± 2.1 versus 6.3 ± 1.4 hours; p<0.001). The time interval from labor induction to delivery was also significantly shorter in the dinoprostoneoxytocin group (6.3 ± 1.5 versus 10.4 ± 1.4 hours; p<0.000). Cesarean delivery rates were statistically similar in the dinoprostone-oxytocin and oxytocin alone groups (17% versus 40%; p=0.102). The neonatal outcomes were comparable in both groups, except for birth weight. Conclusion Intracervical dinoprostone 0.5 mg gel followed 6 hours later by an oxytocin infusion in term women presenting with PROM and an unfavorable cervix (Bishop Score of 5 or less) was associated with a higher rate of vaginal delivery within 24 hours, shorter time interval from labor induction to active phase of labor, and shorter time interval from labor induction to delivery, and no difference in maternal and neonatal complications was observed compared with oxytocin infusion alone.
Dinoprostone ; Oxytocin ; Labor ; Induced

No abstract available.
Amnion* ; Dinoprostone* ; Humans* ; Metabolism* ; Progesterone*

No abstract available.
Amnion* ; Dinoprostone* ; Humans* ; Metabolism* ; Progesterone*