Objective To observe the value of drug therapy by the arterio of thigh in the treatment of osteosarcoma of the leg bones. Methods 13 cases of patients with osteosarcoma of the leg bones were treaded with DDP, ADM and VCR by the arterio of thigh, IFO by phlebo. Results The response rates(PP+CR) to osteosarcoma lesions were 69.2 %. Conclusion The comdination regimen with drug therapy by the arterio of thigh is simple and safe and effective for osteosarcoma of the leg bones, which is worth spreading and applying.

Objective To investigate curative efficacy and safety of Epirubicin in combination with Capecitabine in the treatment of triple-negative breast cancer and its effects on level of serum vascular endothelial growth factor C ( VEGF-C).Methods 86 patients of triple-negative breast cancer who received therapy from January 2013 to December 2014 were selected as research objects.According to therapeutic schemes,those patients were divided into control group(n=42)and observation group(n=44).Control group was treated with epirubicin,while observation group was treated with Epirubicin in combination with Capecitabine.Then, the short-term curative efficacy, adverse events effects,level of VEGF-C were observed and compared.Results After the course of treatment, the short-term curative efficacy ratio in control group and observation group was 59.5% and 65.9% respectively with no statistical difference.During the treatment, the occurrence of neutropenia, hand-foot syndrome, gastrointestinal reaction, cardiac damage and liver function damage in the two groups was statistically same respectively.After post-treatment, in comparison with control group, level of VEGF-C in observation group was statistically lower ( P <0.05 ).Conclusion Epirubicin in combination with Capecitabine is effective for triple-negative breast cancer,which has high short-term curative efficacy ratio and significantly decrease level of VEGF-C with not increasing occurrence of toxic side effects.

Objective To study the effect and mechanism of Gehua Jiecheng decoction (GHJCD),a tra-ditional Chinese herbal medicine compound,on cell cycle regulation factors-Cyclin D1,CDK4 and p27 KIP1 in HBV transgenic mice with hepatocellular carcinoma (HCC)precancerous lesions induced by alcohol.Methods Altogether 24 HBV transgenic mice were randomly divided into normal group,model group and GHJCD group(each n =8).All the mice were sacrificed at the end of the 22 th week,then their livers were dissected.Pathohistological changes of liver were observed by using HE staining,and the expression of CyclinD1,CDK4 and p27 KIP1 protein in hepatic tissue were detected by using immuno-histochemistrical methods.Results Compared with the normal group,the positive expressions of Cy-clinD1 and CDK4 increased and that of p27 KIP1 decreased significantly (P <0.05)in the model group. Compared with the model group,restoration of injured liver tissue was occurred in GHJCD group,and the position expressions of CyclinD1 and CDK4 decreased significantly (P <0.05 )and the expression of p27 KIP1 increased significantly (P <0.05).Conclusion The protective effects of GHJCD on liver injures and HCC precancerous lesions took effects by downregulation of genes of CyclinD1 and CDK4 and upreg-ulation of gene of p27 KIP1 .