Objective To compare the masticatory efficiency of alveolar ridge restored by thermosetting resin full denture base and cast resin full denture base.Methods 30 patients with alveolar ridge were selected and divided intothe two groups by random number table and 15 cases in each group.Full denture with thermosetting resin base was worn in the first month in one group,and masticatory efficiency was measured.Then no false tooth was worn for a week,then full denture with cast resin base for a month,then masticatory efficiency was measured.In the other group,full denture with cast resin base was worn in the first month,and then masticatory efficiency was measured.Then no false tooth was worn for a week,then full denture with thermosetting resin base was worn for a month,then masticatory efficiency was measured.OD value as masticatory efficiency was measured by absorption spectrophotometry.Results The masticatory efficiency(OD value) of full denture with thermosetting resin base was (0.608 ± 0.124),and full denture with cast resin base was (0.885 ± 0.071).The masticatory efficiency of full denture with cast resin base was higher than that with thermosetting resin base (t =14.845,P ＜ 0.05).There was 13 cases of increased masticatory efficiency with hot coagulation resin base denture repair,the improved rate was 43.33 ％,while 24 cases with injection molding denture base denture repair,and the improved rate was 80.00％.The rate with injection molding denture base denture repair was higher than that with hot coagulation resin base denture repair(x2 =31.582,P ＜ 0.05).There was no significant adverse reaction in duration of test among all the patients.Conclusion The definition of full denture with cast resin base manufacture was high,and the masticatory efficiency of full denture with cast resin base is higher than that with thermosetting resin base,and the repair effects is better.It is worth of clinical application.