1.Preparation and in Vitro Dissolution Characteristics of Famotidine Dispersible Tablets
Jianchun ZHANG ; Yuan WANG ; Dingji CHEN ; Chunhong WANG ; Yaxu WEN
China Pharmacy 2001;0(08):-
OBJECTIVE:To study the preparation of famotidine dispersible tablets and to observe the dissolution characteristics in vitro METHODS:To optimize the conditions for preparation by orthogonal design RESULTS:The tablets could completely disintegrate within 1 min;In vitro dissolution test showed T50=0 56min CONCLUSION:In comparison with commercial famotidine tablets,the dispersible tablets prepared in optimum condition were rapid in disintegration and homogenous in dispersal
2.The angiogenesis effect of intermittent hypoxia precondition on ische micmyocardium in rabbits
Hongbo LI ; Runfen CHEN ; Changqian WANG ; Zhaonian ZHOU ; Dingji HUANG
Chinese Journal of Pathophysiology 1986;0(01):-
AIM: To determine the effect of intermittent hypoxia (IH) precondition on ischemic myocardium by using a rabbit model of chro nic myocardial ischemia with left anterior descending (LAD) banding. METHODS: Male, adult New Zealand white rabbits were assigned into three groups randomly. (1) normal group (N group), (2) control group (C group), (3) IH precondition group (H group). A LAD band was placed in C and H group firs t. The rabbits in H group were exposed to altitude of 5 000 m, for 6 h/day c ontin uously. According to IH precondition duration, the animals were subdivided into 7-days group (H1) and 42-days group (H2). After these experiments, the mRNA conc entrations of vascular endothelial growth factor (VEGF), hypoxia induced factor (HIF-1?), endothelial nitric oxide synthase (eNOS) and the expression of VEGF p rotein were detected. Tissue sections were stained for alkaline phosphatase with indoxyl-tetrazolium method to detect capillary density. RESULTS: The mRNA levels of VEGF, HIF-1?, eNOS and expression V E GF protein were increased in H group significantly. Compared with C and N group, the capillary density in H group was increased significantly. CONCLUSION: IH precondition increases angiogenesis in chronic is chemic myocardium in rabbits.