Objective Inquire into the function and mechanisms of Sanye Insect tea of lowering the blood pressure. Method The rat model of renal hypertension was replicated by aqueezing two kidneys (2K1C-RHR) to observe the blood pressure-lowering process of Sanye Insect tea on the change of the content of CGRP, analysis the change with the relation of the AngⅡ level, and compare with Liuwei Dihuang and Captopril Tablets. Result The blood pressure value of renal hypertension rats obviously increased, the blood plasma CGRP lowered and the level of AngⅡ increased. High and low dosages of Sanye Insect tea had this improvement of different degree. Conclusion Sanye Insect tea has the effect of lowering the blood pressure of 2K1C-RHR. Incressing the content of CGRP and regulating the level of Ang Ⅱ to make blood vessel extend is one of the function mechanism of Sanye Insect tea.