Colorectal stem cells have many bio-markers, including Lgr5 which expression is associated with THE stage of disease , also regulating the cell cycle , anothers is +4 stem cell , which is associated with tumor heteroge-neity, also expressed Bmi1, arresting cell cycle.Besides there is Msi1.Many studies show that those markers are highly expressed in colorectal cancer , which activate Notch and Wnt signaling pathway , and can promote the pro-gress of tumor .

Antiviral Agents ; therapeutic use ; Female ; Hepatitis B, Chronic ; drug therapy ; Humans ; Pregnancy ; Pregnancy Complications, Infectious ; drug therapy ; virology

Objective To investigate the mid-term efficacy of retrievable stent filter placement for the treatment of Budd-Chiari syndrome (BCS) complicated with inferior vena cava (IVC) thrombosis. Methods Eight patients of BCS complicated with IVC thrombosis were enrolled in this study. IVC thrombosis included segmental occlusion (n = 2) and membranous occlusion (n = 6). In all patients, the IVC was re-canalized by using blunt wire after anticoagulation and thrombolytic therapy, then, the re-canalized site was expanded with small balloon, which was followed by the placement of retrievable stent filter, and, finally, IVC size was dilated with larger balloon. Anticoagulation and thrombolytic therapy was given after the procedure. And all the retrievable stent filters were withdrawn from the IVC through internal jugular vein when the thrombus in IVC was dissolved. In patients with segmental occlusion of IVC, in addition to the placement of retrievable stent filter a "Z" type vessel stent was also placed during the same interventional session. Follow-up examination with color Doppler sonography was conducted in all patients. Results Technical success was achieved in all 8 patients without pulmonary infarction or other complications both during and after the operation. Immediately after the thrombus completely disappeared, the retrievable stent filter was successfully taken out in all patients. During a following-up period of 3-12 months, color Doppler sonographs showed that the IVC remained patent in 6 patients and had a recurrence of stenosis in 2 patients. Conclusion Placement of retrievable stent filter is a safe and effective treatment for BCS complicated with IVC thrombosis.

Objective:To investigate the influence of auxiliary application of Xuesaitong injection on blood coagulation indices and thromboembolic complications in the patients after finger replantation. Methods:Totally 64 patients with finger replantation were cho-sen from March 2012 to March 2014 in our hospital and randomly divided into the control group (32 patients) treated with low molecu-lar weight heparin and Xuesaitong group (32 patients) treated with Xuesaitong injection additionally. The clinical curative effect, sur-vival time of finger replantation, the levels of blood coagulation indices before and after the operation and the incidence of thrombotic complications in both groups were compared. Results: The clinical curative effect of the control group and Xuesaitong group was 68. 75% and 93. 75, respectively, and that of Xuesaitong group was significantly better than that of the control group (P<0. 05). The survival time of finger replantation of the control group and Xuesaitong group was (9. 44 ± 1. 56)d and (6. 72 ± 2. 28)d, respectively, and that of Xuesaitong group was significantly better than that of the control group (P<0. 05). The levels of blood coagulation indices on 1d, 4d and 7d after the operation in Xuesaitong group was significantly better than those in the control group and those before the treatment(P<0. 05). After the treatment, gastrointestinal hormone levels in Xuesaitong group was significantly better than those in the control group(P<0. 05). The incidence of thrombotic complications in the Xuesaitong group was significantly better than that of the control group(P<0. 05). There was no significant difference in the adverse effects between the two groups (P>0. 05). Conclusion:Auxiliary application of Xuesaitong injection in the patients after finger replantation can efficiently speed up the replantation survival process and improve blood coagulation indices after the operation, which is helpful to reducing the risk of thrombotic complications.

This article summarizes 32 cases of the SCI patients suffered from bladder stones.Respects relating to causes,characteristic,diagnosis,treatment and prevention of bladder stones after SCI are discussed in the article.In order to decrease or avoid complication of indwelling urethral catheter,the patients with neuropathic bladder dysfunction are treated by intermittent catheterization.If it is necessary for SCI patients to indwell urethral catheter,we must strengthen management of the catheter and renew a catheter in time(once a week).

Accidents, Occupational ; prevention & control ; statistics & numerical data ; Adult ; China ; epidemiology ; Female ; Humans ; Male ; Middle Aged ; Poisoning ; epidemiology ; prevention & control

Objective To investigate the clinical manifestations and inlfuencing factors in the newborns with coagulant function abnormality in the ifrst 24 hours after birth. Methods The coagulation test results and clinical data of 169 newborns in our hospital were studied. Children receiving anticoagulant therapy were assigned as coagulation abnormalities group (n=76) and other healthy newborns were assigned as control group (n=93). The differences of coagulation function between the two groups were analyzed and the inlfuencing factors of coagulation abnormalities were explored. Results The proportions of fetal distress, pneumonia, acidosis and hypothermia of coagulation abnormalities group were signiifcantly higher than that of the control group (χ2=6.18–38.01, P<0.05). Logistic regression analysis showed that fetal distress (OR=12.06, 95%CI:3.71–39.25), pneumonia (OR=4.10, 95%CI: 1.43–11.74) were the high risk factors for coagulant function abnormality, and the differences were statistically signiifcant (both P<0.05). Conclusions Fetal distress, pneumonia were the high risk factors for coagulant function abnormality. Early prevention can help to reduce the incidence of neonatal hemorrhagic disease.

Objective To investigate the value of CT signs in combination with clinical materials of papillary thyroid carcinoma (PTC) to predict the central lymph node metastasis (CLNM).Methods This article reviewed the CT signs and clinical materials of 366 patients with surgically and pathologically verified PTC.The single factor and multi-factor logistic regression analyses were performed on the relation of tumor position,thyroid marginal contact,calcification,plain scan border,border after enhancement,diameter,age and sex with CLNM.Results Among the 366 patients with PTC,the number of patients with positive CLNM and negative CLNM was 155 and 211 respectively.The single factor and multi-factor logistic regression analysis indicated that the thyroid marginal contact,diameter,age and sex were related with CLNM,and the more common patients diagnosed with CLNM had the following features:thyroid marginal contact,a diameter ＞1.0 cm,age ＜45 years and males (P＜ 0.05).Among the single risk factors,the tumor position,calcification,plain scan border and border after enhancement were unrelated with CLNM (P＞0.05).Conclusion The thyroid margin contact,diameter＞l.0 cm,age＜45 years and males are independent risk factors in diagnosis of positive CLNM.

Objective: To observe the clinical effect of early intervention of combined tuina with medicated bath for neonatal brain injuries.Methods: Brain-benefiting tuina manipulations,medicated bath and music plus exercise therapies were employed in 60 infants with medium or severe brain injuries.The Gesell measurement methods were adopted prior to and 3 months after treatment to evaluate the development quotient(DQ).In addition,the long-term follow-up was made after one and a half years.Result: The scores of DQ prior to treatment,3 month after treatment and 1.5 years after treatment were(34.98±28.94),(66.17±14.91)and(75.40±14.69)respectively,showing a marked improvement after 3months and 1.5 years of treatment(P=0.000).Conclusion: Early intervention using tuina manipulations could enhance the brain development,repair the nerve injury,improve the motion and cognitive ability and prevent the sequela of the nervous system.

Objective To discuss the efficacy of the modified falling risks for older people-community setting screening tool and the falling risks of the older people.Methods A cross-sectional study was conducted in 4 communities of Chengdu.A total of 408 people aged 65 years and over from 4 residents communities were selected with convenient sampling.To screen out the people who were in high risk of falls with a self-making questionnaire and the modified falling risks for older people-community setting screening tool.Results After the 408 older people were evaluated by modified falling risks for older people-community screening tool,the result showed the area under curve of receiver operating characteristic of the scale was 0.936.Its sensitivity was 77.6％ (66/85),specificity was 93.2％ (301/323),positive predictive value was 75.0％ (66/88) and negative predictive value was 94.1％ (301/320).Conclusions The using of modified falling risks for older people-community setting screening tool is easy and fast,it has higher sensitivity,specificity and evaluation function.It can be used for screening falling risks among community setting elderly people in China.