Objective To analyze the relative factors of bone marrow suppression after chemotherapy with different-dose carboplatin and paclitaxel (TC) on the patients with ovarian cancer.Methods Sixty-two patients with ovarian cancer admitted in Beijing Obstetrics and Gynecology Hospital from January 2002 to December 2007, using TC regimen ,a total of 196 cycles of chemotherapy ,were divided into two groups by the doses of carboplatin [area under concentration-time curve(AUC) 4 -6 for low-dose,AUC >6 -7 for hight-dose, the carboplatin dose calculated with AUC] or by the doses of paclitaxel (135 -< 150 mg/m2 low-dose,150 - 175 mg/m2 hight-dose). After each TC cycle, the routine blood was test to determine the graduation of the marrow suppression, and then the correlation factors were analyzed with logistic regression. Results (1) The occurrence rate of bone marrow suppression:there were 159 cycles (81.1%) grade 0 - Ⅱ bone marrow suppression, while 37 cycles (18.9%) of grade Ⅲ - Ⅳ. (2) Factors related to bone marrow suppression:the results shown that there were not related to bone marrow suppression,which incluced cellular differentiation, tumor type, height, weight and paclitaxel dose(P>0.05). While,the different cycle, age, the later stages of tumor, serum creatinine concentration, endogenous creatinine clearance rate, AUC values were the relative factors of bone marrow suppression(P =0.000,0.000,0.018,0.033,0.001,0.000). Seven variables were conducted into the logistic regression and the results shown that the different cycles, the age, AUC grades were independent risk factors (P = 0.030,0.043,0.009).(3) When low-dose of paclitaxel was given, the occurrence of bone marrow suppression was related to the carboplatin dose AUC. The higher AUC values for carbopaltin were chosen, the higher of severe bone marrow suppression would happen. (4/14 vs 0,P=0.015). When the dose of high grade of paclitaxel was given, the occurrence of bone marrow suppression in cases with hight-dose carboplatin was statistically significant than that in cases treated with low-dose carboplatin [45.7%(16/35) vs 13.7% (17/124), P=0.000]. Conclusions The independent risk factors of myelosuppression after chemotherapy with TC regime on the patients with ovarian cancer including the cycles, age and AUC values. The carboplatin dose calculating with AUC is related to the occurrence of bone marrow suppression, the higher AUC values for carbopaltin would chosen,the higher of severe bone marrow suppression would be happen.

ObjectiveTo explore the ability of inhibition resistibility of multiple displacement amplification (MDA)in samples with inhibitors. To explain the application and value of MDA in forensic medicine by comparing with using magnetic beads methods(MBM)to purify sample.MethodsDifferent concentra-tions of hemoglobin and humid acid(HA)mixed with DNA samples and then divided the samples into MDA group, MBM group and control group.D3S1358locus was amplified and detected by polyacry-lamide gel electrophoresis detection system and AmpF?STR? IdentifilerTM Plus Kit-capillary electrophore-sis detection system.ResultsWhen hemoglobin concentrations exceed 1 ng/μL or HA concentrations ex-ceed 0.1 ng/μL, amplification products could not be obtained by single-locus system in control group. When hemoglobin concentration exceeds 100 ng/μL or HA concentrations exceed 1 ng/μL, the samples could not be amplified by MBM. Inhibitors in different concentrations were amplified successfully in MDA group without any influence from inhibitors.ConclusionMDA has the capability to remove the inhibi-tion of hemoglobin and HA, which is better than MBM and has a certain value in forensic practices.

Objective To observe the efficacy and side effect of olanzapine combined with tropisetron, dexamethasone for the pre-vention of highly emetogenic chemotherapy-induced nausea and vomiting ( CINV) . Methods A total of 78 patients with highly emetogen-ic single day chemotherapy were randomly divided into two groups:trial group ( olanzapine combined with tropisetron, dexamethasone n=40) and control group (Tropisetron Combined with Dexamethasone n=38). The control of acute CINV, delayed CINV and adverse reac-tions were observed. Results The control rates of acute vomiting in trial group and control group were 87. 5% vs 81. 6%, 65. 0% vs 57. 9% in acute nausea, 75. 0% vs 52. 6% in delayed vomiting, 32. 5% vs 13. 2% in delayed nausea. The trial group was better than the control group in delayed vomiting and delayed nausea which there was difference between them (P < 0. 05). There was no statistical differ-ence between the two groups in the incidence of adverse reactions (P>0. 05). Conclusion Olanzapine combined with tropisetron, dexa-methasone for the prevention was significantly better than tropisetron combined with dexamethasone in the control of delayed CINV in pa-tients received highly emetogenic chemotherapy.

Objective To explore the effect of yam polysaccharide for the diabetic mice. Methods Ninty mice were randomly divided into three groups ,yam polysaccharide group(n = 30), glibenclamide group (n = 30) and control group(n = 30). Mice were Intraperitoneal injection of alloxan (200mg/kg) to establish diabetic model. Yam polysaccharide group was administered yam polysaccharide for 12d. Results Yam polysaccharide significantly decreased the blood sugar of the diabetic mice. There were not significantly different in two groups (P ＞ 0.05).Conclusion Yam polysaccharide had obvious role in decreasing blood glucose.

BACKGROUND:Carbon-fiber-reinforced polymer energy-storing transtibial prostheses are mature and ideal substitutes for professional disable athletes to increase performance.
OBJECTIVE:By discussing the update application and study of the carbon-fiber-reinforced polymer energy-storing transtibial prosthesis and understanding the characteristics of applying transtibial prostheses in different sports program, to provide a useful reference for the design of athletes prostheses.
METHODS:A computer-based search of PubMed and VIP databases was performed for articles related to carbon-fiber-reinforced polymer energy-storing transtibial prostheses published from January 1985 to December 2012. The keywords were“CFRP, energy-storing prosthesis, between-knee (transtibial) prosthesis, disable athletes”in English and Chinese, respectively.
RESULTS AND CONCLUSION:Currently, we focus on the gait analysis, energy cost and stiffness analysis of athletes who wear carbon-fiber-reinforced polymer energy-storing transtibial prostheses. Studies have demonstrated that carbon-fiber-reinforced polymer energy-storing transtibial prostheses have more advantages over traditional prostheses, but have predominantly disadvantages over able-bodied persons. Thus, there are many difficulties in the clinical application of building carbon-fiber-reinforced polymer energy-storing transtibial prostheses based on the characteristics of athletes’ body status and sports programs.

Objective: To explore how to set up the service management center of ventilators depending on department of respiratory medicine , how to perfect daily management of ventilators, how to rationally and timely allocate ventilators ,how to reduce the fault of ventilators and ensure the safe use of ventilators, and how to cost savings of purchasing ventilators. Methods: To figure out and compare data of before and after the establishment of the service management center of ventilators in 2010 and in 2012. Results: Non machine failure rate was 42.86% in 2012 and 69.35% in 2010, had remarkably decreased. At the same time, the total failures have decreased significantly. Conclusion: Setting up the service management center of ventilators depending on department of respiratory medicine have achieved timely allocation ventilators, have improved the level of medical personnel of using ventilators, have ensured the safe use of ventilators, have cost savings of purchase ventilators, have reduced the fault of ventilators.

Objective To compare the effect and safety of methotrexate applied partly and systemically to treat cesarean scar pregnancy.Methods 21 patients diagnosed with cesarean scar pregnancy were selected and set to observation group.50mg methotrexate was injected into the masss of attachment with guide of ultrasound.19 patientswith cesarean scar pregnancy were set to control group,and methotrexate was intramuscular,1 mg/kg weight.Mifepristone was used in both groups,50mg a time,bid for 3 days.Results The cure rate of observation group was 95.2％,while 68.4％ in control group,the former was higher than the latter(P ＜ 0.05).The time of concentration of β-HCG recovery and masss of attachment disappearing were (15.3 ± 2.1) d and (31.8 ± 9.5) d,while those in control group were (30.8 ±7.4)d and (55.7 ± 12.1) d,and the time of observation group was shorter than that of control group (P ＜0.05).4 cases of adverse reactions were observed in observeation group,while 13 cases in control group,the incidence of adverse reactions in observation group was lower than that in control group(P ＜ 0.05).Conclusion The effect of methotrexate applied partly was better than systemically,less dosagation and better safety.

Objective To study the efficacy of pigtail catheter and central venous catheter in pneumothorax by thoracic close drainage.Methods 67 pneumo thoraxpatients were randomly divided into two groups,pigtail catheter group with 29 patients and central venous catheter group with 38 patients.The efficacy,ICU stay time and total hospitalization were compared.Results The efficacy in pigtail catheter group was 93.1％ (27 of 29 patients) and in central.venous catheter group was 73.7％ (28 of 38 patienes),a significant difference was observed (x2 =4.22,P ＜0.05).ICU stay time and total hospitalization in pigtail catheter group were(13.2 ± 6.3) d and (34.3 ± 21.4) d,in central venous catheter group there were(19.7 ± 8.3) d and (43.2 ± 25.5) d,significant differences were observed (t =2.42,2.13,all P ＜ 0.05).Conclusion Thoracic close drainage with pigtail catheter in the treatment of pneumothorax is more effective than central venous catheter.

Objective To observe the clinical effect of singulair (montelukast sodium chewable tablets) combined with Zithromax(Azithromycin for Suspension) in treatment of children with asthma.Methods 86 children with asthma were randomly divided into control group and observation group,each group 43 cases,observation group was treated with singulair and zithromax,and control group was only treated with singulair.Before and after treatment,pulmonary function and clinical efficacy were observed.Furthermore,clinical symptoms disappearance time and the incidence of adverse reactions were also observed.Results After teratment,FEV1 and PEF in observation group were significantly higher than control group(P ＜ 0.05).The total effective rate in observation group and control group were 97.7％ and 88.9％,respectively.The difference between two groups was statistically significant(P ＜0.05).Observation group coughing,shortness of breath and wheeze and other symptoms disappeared time were shorter than the control group(P ＜ 0.05).Adverse reactions between the two groups had no significant difference (P ＞ 0.05).Conclusion Singulair combined with zithromax in the treatment of chronic pelvic inflammatory disease with a better therapeutic effect.It was worthy of clinical application.

Objective To explore the influence of probucol on high-sensitive C-reactive protein (hs-CRP)and homocysteine(Hcy) of patients with non-ST-segment elevation acute coronary syndrome.Methods 82 patients with non-ST-segment elevation acute coronary syndrome were randomly divided into two groups,the control group (40 cases) and the treatment group (42 cases).The patients in the control group were treated through the conventional treatment,while the patients in the treatment group were treated by probucol on the basis of conventional therapy.They were all treated for three months.Serum levels of hs-CRP and Hcy were detected before and after treatment.Results Serum levels of hs-CRP and Hcy were all decreased after treatment in both two groups.The hs-CRP and Hcy in the treatment group were significantly improved than those of the control group [(0.82 ± 0.43) mg/L vs (1.05 ± 0.52) mg/L,(10.08 ± 7.18) μnol/L vs (15.73 ± 9.16) μmol/L,t =2.1871,3.1168,all P ＜ 0.05].Conclusion Probucol can significantly decrease the serum levels of hs-CRP and Hcy in patients with non-ST-segment elevation acute coronary syndrome.