Objective To investigate the morphological difference of spinal single vertebral tuberculosis and metastasis by means of CT.Methods CT features of 16 cases of single vertebral tuberculosis and 17 cases of single vertebral metastasis which were proven by clinically and/or pathology, were retrospectively analyzed,and then the CT differential criteria of the two categories of diseases was recommended.Results The reliable CT findings for vertebral tuberculosis were as follows: involvement of anteriomedial potion of vatebral body,presence of sequstra in lesion ,marginal sclerosis in the edge of lesion,calcification within paravertebralmass or abscesses ,only edge enhancement of more of paravertebralmass.Metastasis was characterized by involvement of posteriomedial portion of vertebral bone,absence of sequestra within lesion ,no calcification within paravertebralmass.Both of them had normal intervertebral disc.Conclusion The different CT features of the single vertebral tuberculosis and metastasis are helpful in differerntiating diagnosis ,the morphological change of intervertebral discs is not helpful in differerntiating diagnosis .

Bile reflux is not only related to diseases such as gastritis,esophagitis,pharyngitis,chorditis,bronchitis and pneumonia,but also related to residual gastric ulcer,residual gastric cancer,intestinal metaplasia,dysplasia and carcinogenesis. Risk factors related to bile reflux include various operation modes, various anastomosis methods, gallbladder stone, cholecystectomy and various non-operative factors such as age, gender, allergy, mental and psychological factors,congenital factors. This article reviewed the advances in study on risk factors related to bile reflux.

Aged ; Humans ; Lung Diseases, Fungal ; complications ; microbiology ; Male ; Pneumoconiosis ; complications

Objective To discuss the strategies of lower complications of LC in the initial stage. Methods The clinical data of 168 patients,from Sep. 2008 to May. 2010 ,treated with laparoscopic cholectectomy were retrospectively analyzed. Results LC was performed in all patients(100%). None of the series had intra-abdominal bleeding,biliary tract injury and no other serious complications were observed. Conclusion Through correct perioperative management and meticulous operation, LC was safe and complications lower in the initial stage.

Objective To discuss the clinical value of intercostal arterial embolization for the treatment of hemoptysis.Methods A total of 91 patients with hemoptysis were enrolled in this study.Intercostal arterial embolization was performed using gelatin sponge.The patients were closely observed after the operation.For recurrent cases,re-embolization was carried out after identifying the causes of relapse.Results A total of 111 operations were performed on the 91 patients,including embolization of the bronchial and intercostal arteries in 74 cases,and simple embolization of the intercostal artery in 17.The rate of immediate hemostasis was 98.9%(90/91).The patients were followed up for 8 to 14 months,during which the recurrent rate was 15.4%(14/91).No serious complication occurred during the follow-up.Conclusion By embolizing both bronchial and intercostal arteries,the efficacy of the procedure can be increased and the rate the recurrence decreased,as long as proper measures have been taken to avoid serious complications.

Objective To study the levels of ? amyloid protein(A?/?A 4) in cerebrospinal fluid(CSF) of patients with Alzheimer's disease(AD) and vascular dementia(VD) and its significance of diagnosis.Methods The levels of A? 1 40 and A? 1 42 in CSF of 24 patients with AD, 14 patients with VD and 30 normal controls(NC) were detected by enzyme linked immunosorbent assays(ELISA).Results (1)The levels of A? 1 42 in CSF of AD and VD patients were significantly lower than NC group ( P

Objective To study the relationship between large multifunctional proteasome (LMP) 7 gene polymorphism and susceptibility of type 1 diabetes mellitus (DM). Methods The genotyping of LMP7 gene was determined by polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) in 71 type 1 DM patients and 86 healthy persons (as controls). Furthermore, the type 1 DM patients were divided into 3 groups according to the age of diabetic onset. Group A was ≤14 years, group B 15～30 years, group C≥31 years.Results The frequency of LMP7 B/B was decreased significantly (39% vs 58%, P

Breast Neoplasms ; diagnosis ; genetics ; pathology ; Clinical Laboratory Techniques ; adverse effects ; trends ; Diagnostic Errors ; Female ; Genes, BRCA2 ; physiology ; Humans

Angelica ; chemistry ; Animals ; Animals, Newborn ; Cell Count ; Female ; Fetal Hypoxia ; pathology ; Hippocampus ; cytology ; drug effects ; Male ; Neuroglia ; cytology ; Neurons ; cytology ; Pregnancy ; Rats ; Rats, Sprague-Dawley

Protein Kinase C (PKC) is an important messenger in intracellular signal transduction. So far, at least 11 members of PKC isoforms have been isolated and purified. The mutation of the non-synonymous SNP (1425G/A) of the η isoform of protein kinase C (PKC η), a protein kinase Cη gene (PRKCH) may result in the increased PKCη activity, which is considered as a new risk factor for lacunar infarction. In recent years, the studies about the role of PRKCH in cell differentiation and apoptosis and its relation with some signal transduction pathways have made some new advances, especially, PKCη participates in the regulation of some key enzyme activity that mitogen-activated protein kinase, inducible nitric oxide-synthase and matrix metalloproteinase are closely correlated with the process of atherosclerosis. It will provide a new way of thinking for the clinical intervention of cerebral infarction in the future.