An open, randomized and prospective study was conducted at the H÷u NghÞ Hospital. Participants were 30 male patients with type II diabetes with age ranged from 50-80 years. The results showed that age, duration of disease, hypertension, hypercholesteremia and hypertriglyceremia related to major vascular complications. Type II diabetics with hypertension need to control the blood pressure to slow the progress of major vascular complications. Individuals who have high BMI without diabetes should take physical exercise to prevent from diabetes.
Diabetic Angiopathies ; Diabetes Mellitus

No abstract available.
Bilirubin* ; Diabetic Angiopathies* ; Liver Diseases* ; Liver*

OBJECTIVE: To investigate and describe the peak plantar pressures and ground contact times of the foot during walking in diabetic patients and healthy adults. METHOD: 17 age-matched diabetic patients without any complications and 33 healthy adults participated in this study. The foot was divided into 10 different areas, and peak plantar pressures and ground contact times were measured during walking by EMED system . RESULTS: There were no significant differences in peak plantar pressures of both feet in both groups, but there were significant increases in peak plantar pressures of hindfoot and hindfoot contact times in the diabetic group. CONCLUSION: Despite having no definite diabetic neuropathy and vascular disease, diabetic patients have higher peak plantar pressures of hindfoot and prolonged hindfoot contact times because limb muscle dysfunction or impairment of proprioception may induce faster descent of the foot towards the ground or improper pattern of stance phases.
Adult* ; Diabetic Angiopathies ; Diabetic Neuropathies ; Extremities ; Foot ; Humans ; Proprioception ; Walking

Officers and cadres of various governmental bodies were subjected to this study conducted in Huu Nghi Hospital in the past 10 years (1991-2001). The incidence of cardiovascular and diabetic deseases increased following the anthropometric and nutritional increasing parameters. The mortality of cardiovascular diseases reduced considerably, the mortality of diabetes also reduce with no statistical significant. The incidence of diabetes and hypertension has a positive correlation with blood cholesterol and triglycerid high levels and with BMI and obesity
Cardiovascular Diseases ; Diabetic Angiopathies ; Diseases ; epidemiology ; Nutritional Status

PURPOSE: This study analyzed protein alterations between the normal vitreous and the vitreous with proliferative diabetic retinopathy by proteomics to find the proteins which may elicit diabetic retinopathy. METHODS: Two-dimensional electrophoresis was used to make the protein map. Image analysis between the spots on each gels by a proteomics based approach were used to reveal vitreous protein alterations which may elicit proliferative diabetic retinopathy. MALDI-TOF/ESI-TOF mass spectrometry also was used to identify altered protein spots on the gel. RESULTS: Of the 110 different spots on each gels, 36 different proteins were identified and among them 23 proteins were altered in the vitreous with proliferative diabetic retinopathy compared with normal vitreous. Nineteen proteins including alpha-1-antitrypsin, Ig G and A, and complement C3 and C4 were increased in the vitreous with proliferative diabetic retinopathy and 4 proteins includng pigment epithelium derived factor were decreased compared to the normal vitreous. CONCLUSIONS: The authors found that pigment epithelium derived factor may be the key protein that induces the neovascularization in the vitreous with proliferative diabetic retinopathy. Increased levels of Ig G and A and C3 and C4 is thought to be related to the autoimmune inflammation in early diabetic microangiopathy. Furthermore, proteins such as alpha-1-antitrypsin may contribute to protective functions of the ischemic retinal cells.
Complement C3 ; Diabetic Angiopathies ; Diabetic Retinopathy* ; Electrophoresis ; Epithelium ; Gels ; Inflammation ; Mass Spectrometry ; Proteomics ; Retinaldehyde

OBJECTIVE: To report a case of radiation retinopathy, a common complication in the treatment of nasopharyngeal carcinoma. METHOD:This is a case report. RESULTS:A 59-year-old Chinese man with a history of external beam irradiation for nasopharyngeal carcinoma presented with mild blurring of vision of the left eye.Examination revealed bilateral scattered cotton-wool spots, intraretinal hemorrhages, and microaneurysms.The left eye had peripapillary cotton-wool spots and hemorrhages, disc edema, and semimacular star.Funduscopic findings were similar to those of diabetic retinopathy except for the abundance of cotton-wool spots and the presence of macular star. CONCLUSION:Radiation retinopathy usually develops 6 months to 3 years after exposure.In this patient, it occurred 2 years after radiotherapy.Neovascularization at the disc developed 15 months after initial presentation, which required treatment with panretinal photocoagulation, resulting in regression of the new vessels.As severe late ocular complications frequently occur after radiation therapy, periodic ophthalmologic examinations should be considered.
Human ; Male ; Middle Aged ; NASOPHARYNGEAL NEOPLASMS ; RETINAL NEOVASCULARIZATION ; DIABETIC ANGIOPATHIES ; DIABETIC RETINOPATHY ; ;

Foot complications are a well known factor which contribute to the morbidity of diabetes and increases the chance of amputation. A total of 126 consecutive diabetic patients were evaluated by diabetic foot screening. Forty-one patients showed an impaired protective sense when tested with Semmes-Weinstein monofilament 5.07 (10 g), and 92% of them showed peripheral polyneuropathy in nerve conduction study (NCS). The mean vibration score of the Rydel-Seiffer graduated tuning fork in patients with peripheral polyneuropathy in nerve conduction (NCV) study was 5.38+/-2.0, which was significantly different from that of patients without polyneuropathy in NCS. Among the deformities identified on examination, callus, corn, and hallux valgus were the greatest. While checking the ankle/ brachial index (ABI), we also evaluated the integrity of vasculature in the lower extremities. After extensive evaluation, we classified the patients into eight groups (category 0,1,2,3,4A,4B,5,6). The result of this study suggested that the Semmes-Weinstein monofilament test, Rydel-Seiffer graduated tuning fork test, and checking the ankle/brachial index were simple techniques for evaluating pathologic change in the diabetic foot by office screening, and that this screening based on treatment-oriented classification helps to reduce pedal complications in a diabetic population
Diabetic Angiopathies/diagnosis ; Diabetic Angiopathies/complications ; Diabetic Foot/physiopathology ; Diabetic Foot/diagnosis* ; Diabetic Foot/classification ; Diabetic Neuropathies/diagnosis ; Diabetic Neuropathies/complications ; Female ; Foot/physiopathology ; Human ; Male ; Mass Screening ; Middle Age ; Podiatry/methods ; Sensory Thresholds

Nodular glomerulosclerosis was first described by Kimmelstiel and Wilson in 1936. Diabetic retinopathy and nephropath y are manifestation of the microangiopathy associated with diabetes. The severity of diabetic nephropathy and the occurrence of retinopathy correlate with the duration of clinical diabetes. However, there have been few reports of patients presents presenting with the classic lesions of diabetic microangiopathy in the absence of a known history of diabetes. These reports raise questions regarding the relationship and significance of carbohydrate intolerance to these pathologic abnormalities. A 34-year-old male patient clinically characterized by massive proteinuria and hypertension without evidence of systemic disease is reported. Renal biopsy showed the nodular glomerulosclerosis (Kimmelstiel-Wilson lesion) characteristic of diabetes. Direct opthalmoscopy and fluorescein angiography demonstrated a picture of advanced proliferative diabetic retinopathy. The patient had no history of diabetes mellitus and upon testing had normal glucose values in response to an oral glucose tolerance test. It is concluded that the nodular glomerulosclerosis lesions and proliferative retinopathy, thought to be specific for diabetes mellitus, may present in the absence of either overt clinical diabetes or impaired glucose tolerance.
Adult ; Biopsy ; Diabetes Mellitus* ; Diabetic Angiopathies ; Diabetic Nephropathies ; Diabetic Retinopathy ; Fluorescein Angiography ; Glucose ; Glucose Tolerance Test ; Humans ; Hypertension ; Male ; Proteinuria

Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in subjects with diabetes. Disorders of the physiological signaling functions of reactive oxygen species (superoxide and hydrogen peroxide) and reactive nitrogen species (nitric oxide and peroxynitrite) are important features of diabetes. In the absence of an appropriate compensation by the endogenous antioxidant defense network, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause cellular damage and contribute to the vascular complications of diabetes. It has recently been suggested that diabetic subjects with vascular complications may have a defective cellular antioxidant response against the oxidative stress generated by hyperglycemia. This raises the concept that antioxidant therapy may be of great benefit to these subjects. Although our understanding of how hyperglycemia-induced oxidative stress ultimately leads to tissue damage has advanced considerably in recent years, effective therapeutic strategies to prevent or delay the development of this damage remain limited. Thus, further investigation of therapeutic interventions to prevent or delay the progression of diabetic vascular complications is needed.
Compensation and Redress ; Diabetic Angiopathies ; Hydrogen ; Hyperglycemia ; Nitrogen ; Oxidative Stress ; Oxygen ; Reactive Nitrogen Species ; Reactive Oxygen Species

Latest guidelines on lipid management recommend statins as the first-line therapy. Because limited evidence is available on cardiovascular outcomes with varying statin-nonstatin combinations, recommendation levels for these regimens have been weak. However, a recent trial has demonstrated the additive effect of the statin-ezetimibe combination. The statin-fibrate combination has shown an effect in certain subgroups and on diabetic microangiopathy. Recent trials using the statin-niacin combination have been largely negative, whereas the statin-omega-3 fatty acids combination demonstrated a positive effect only in one study. Identifying the benefits and limitations of each combination is important for the best possible management of patients.
Diabetic Angiopathies ; Drug Therapy* ; Ezetimibe ; Fatty Acids ; Fibric Acids ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Niacin