Blood vessels are indispensible for tumor growth and metastasis.Traditional antiangiogenic strategy reduce the density and the supply of tumor blood vessels.Recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy.Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues,which fosters tumor cells to become more aggressive and metastatic.Tumor vascular normalization may be an alternative approach to treat cancers,normalize the disorganized tumor vasculature,rather than disrupting or blocking them,thus reduce tumor hypoxia as well as increase the efficacy of chemotherapy,radiotherapy and immunotherapy.

Childhood autism is an extensive developmental disorder.Abnormal neuroimaging and neuropathology brain structure research of autistic children in recent years are reviewed in this paper.Brain structure researches have showed the brain volume increased in children with autism,normally occuring to the frontal lobe,temporal lobe.Brain function researches have shown that children with autism have abnormal activity in the fusiform gyrus,superior temporal gyrus,and inferior frontal lobe.Brain metabolites studies have shown that children with autism present glutamate and gamma-aminobutyric acid and serotonin metabolism disorder.Immunological studies have found that children with autism have proinflammatory factor and the emergence of a brain protein antibody.

OBJECTIVE:To provide information about the brand positioning of pharmaceutical products for reference of Chinese pharmaceutical business.METHODS:We overviewed the implication and foundation of brand fixed position of phar?maceutical products and put forward the tactics of brand positioning of pharmaceutical products.RESULTS&CONCLU?SION:Under the conditions of sectionalized market and individulized consumption,nowadays,the existence and development of an enterprise directly depend on the success of brand positioning of its pharmaceutical products.

Background and purpose:δ-catenin is a member of the p120 catenin subfamily, which can directly bind to E-cadherin on the cell membrane, forming E-cadherin/catenin complex. δ-catenin can also affect the cytoskeleton assembly by regulating the activity of Cdc42 (Small GTPase). Therefore, this study detected the expression of δ-catenin and Cdc42 in non-small cell lung cancer (NSCLC) and investigated the relationship between them.Methods:The expressions of δ-catenin and Cdc42 in 122 cases of NSCLC were detected by immunohistochem-istry. This study also used Western blot and real-time lfuorescent quantitative polymerase chain reaction (RTFQ-PCR) to detect the protein and mRNA expressions of δ-catenin and Cdc42 in lung cancer tissues. After up-regulating or down-regulating δ-catenin in lung cancer cell line, the activity of Cdc42 and invasion ability of lung cancer cells were detect-ed by G-LISA and Transwell.Results:The mRNA and protein expression of δ-catenin and Cdc42 in lung cancer tissues was signiifcantly higher than that in normal lung tissues. In 122 NSCLC cases, the δ-catenin positive expression rate was 65.57% (80/122), and the Cdc42 overexpression rate was 68.03% (83/122). There was a good correlation betweenδ-catenin positive expression and Cdc42 overexpression (P<0.001). The co-expression of δ-catenin and Cdc42 was related to the high clinical stage, poor differentiation, adenocarcinoma and lymph node metastasis of lung cancer (P<0.05), and was signiifcantly associated with poor prognosis in patients with lung cancer. In the lung cancer cell line, the expression and the activity of Cdc42 were changed by regulating the δ-catenin expression, which affected invasion ability of the lung cancer cells.Conclusion:The δ-catenin expression was significantly correlated with the Cdc42 expression. The co-expression of δ-catenin and Cdc42 in lung cancer was correlated with the poor prognosis of lung cancer.

AIM:To investigate the effects of different lighting on the reproductive system in depressive female rats.METHODS:Healthy adult female rats were randomly chosen as control group , and the depressive adult female rats in SPF grade were randomly divided into 5 groups (7 rats each):depressive model group, sulfur lamp group, heat radia-tion lamp group , fluorescent lamp group and LED lamp group .After 45 d of continuous illumination , the estrous cycle was observed by the vaginal exfoliated cells , and the organ indexes of ovary and uterus were calculated .The concentrations of estiadrol (E2), prolactin (PRL), progesterone (PROG) and testosterone (T) in the serum were detected by ELISA, and the histopathological lesion of ovary was observed under microscope with HE staining .RESULTS:The estrous cycle exhib-ited serious disorder , the ovaries exhibited serious congestion , and the organ indexes of ovary and uterus and the concentra-tions of E2 , PRL, PROG and T decreased significantly in the rats in depressive model group compared with control group (P<0.05).The estrous cycle and histopathological damage of ovary were obviously improved , and the concentrations of E2 , PRL, PROG and T were significantly increased after the sulfur lamp lighting in the depressive female rats compared with depressive model group .No obvious change and improvement of the reproductive functions in the heat radiation lamp group, fluorescent lamp group and LED lamp group was observed .CONCLUSION:The reproductive functions of depres-sive female rats are improved by sulfur lamp lighting .

Female ; Humans ; Polycystic Ovary Syndrome ; drug therapy

HIV /AIDS related lymphoma (ARL)are a group of heterogeneity of neoplasms,and they have poor prognosis.The factors of pathogenesis elucidated in recent years include immune injury caused by HIV,EB virus infection and genetic changes.There are four pathological types of ARL,including diffuse large B cell lymphoma,Burkitt lymphoma,plasmablastic lymphoma and primary effusion lymphoma.Morphological characteristics,immunophenotype markers and clinical data should be combined to make diagnosis and differen-tial diagnosis,which will facilitate timely treatment and improve prognosis.

Objective To determine the associations of visceral adipose tissue area and retinol binding protein 4(RBP4) with bone mineral density (BMD) in the postmenopausal patients with type 2 diabetes mellitus (T2DM).Methods The cross-sectional study involved 69 postmenopausal patients with T2DM (aged 40-73 years) in our hospital,they were divided into 4 groups:group 1:BMI ＜26.0 kg/m2,VAT＜ 155.3 cm2 ; group 2:BMI ＜ 26.0 kg/m2,VAT＞ 155.3 cm2 ; group 3:BMI ＜26.0 kg/m2,VAT＜155.3 cm2;group 4:BMI＜26.0 kg/m2,VAT＞155.3 cm2.The visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area were obtained by computed tomography(CT) and BMD was measured by dual energy X-ray absorptiometry (DEXA).Results VAT area had negative associanons with lumbar spine BMD (LS-BMD) and greater trochanter BMD (GT-BMD) (r=-0.367,r=-0.301),and with LS-BMD,GT-BMD,femoral neck BMD (FN-BMD) and intertrochanter BMD (IT-BMD) even after adjusting for body mass index(BMI) and SAT (r =-0.433,-0.432,-0.300,-0.297,all P＜0.05).A negative relationship was showed between LNRBP4 and LS-BMD in postmenopausal female patients (all P ＜ 0.05.) The postmenopausal female patients with T2DM were divided into four groups according to the mean values of BMI and VAT area.BMD at any site of group 3(LS-BMD:1.00±0.20,FN-BMD:0.82±0.17,IT-BMD:1.13±0.21,GT-BMD:0.76±0.18) were higher than group 2(0.79±0.14,0.70±0.10,0.95±0.14,0.58±0.11).The multiple regression indicated that the variation of predictors (age,DUR,BMI,VAT,HbA1c,FINS and PMT) explained 51.7％,52.2％,59.8％ and 75.3％ of the variation in LS-BMD.FN-BMD,IT-BMD,GT-BMD among subjects,respectively(all P＜0.01).Conclusions The influence of fat on bone density may depend on its site of VAT or SAT.VAT could be an independent determinant factor of BMDin the postmenopausal female with T2DM.Serum RBP4 may contribute to this effect.

ObjectiveTo study the changes of cardiac autonomic nervous function and EEG non-linear dynamics character in depressive patients,and to explore the functional activity state of brain.Methods24-hour ambulatory ECG was recorded in 47 depressive patients and 47 normal control people by multi-channel ECG machine.The index of heart rate variability,the incidence of arrhythmias and the relationship between HRV and the severity of depression were analyzed.ResultsCompared with the control group,the standard deviation of NN intervals(SDNN)((91.31±15.11)ms),the standard deviation of normal number of intervals(SDANN)((82.14±16.26)ms),the root mean square of successive differences (RMSSD)((37.13±8.02)ms),the percentage of pairs of adjacent RR intervals differing by >50 ms (PNN50)(11.05±7.02) and High-frequency(HF)((17.07±4.34)ms) in depression group were lower,however low-frequency(LF)((18.27±6.32)ms) and LF/HF((1.07±0.33)ms) were higher(P<0.05).There were positive linear correlation between depression severity and LF/HF(P <0.05,r=0.332) and negative linear correlation between depression severity and SDNN(P<0.05,r=-0.296).Compared with control group,the incidence rate of arrhythmia of depressive group was increased,especially in supraventricular arrhythmias.In quiet state with eyes closed: compared with the control group,the level of correlation dimension (D2) in left occiput,left middle and behind temple region were increased in group A,but the difference was not statistically significant.In group B,except prefrontal area,the D2 of the left hemisphere were increased especially in the left central area(3.91±0.37),left parietal lobe(3.85±0.43),left occipital(4.10±0.54)and left temporal(4.20±0.61) compared with control group (P<0.01).The brain electrical activity in other areas were not found change.ConclusionThe cardiac autonomic nervous function of depressive patient is positively correlated with the the severity of depression.Depressive patients are likely to conduct supraventricular arraythmia.Left hemisphere cerebral cortex is active in depressive patients by analysing the EEG non-linear dynamics character.

OBJECTIVE:To investigate the characteristics and regularity of adverse drug reaction (ADR) in a third grade class A hospital,and to provide reference for rational drug use in clinic. METHODS:A total of 813 cases of ADR reported to Na-tional ADR Monitoring by the hospital during 2013-2015 were summarized and analyzed retrospectively in terms of age,gender,route of administration,drug type,organs or systems involved in ADR,clinical manifestation and outcome. RESULTS:Among 813 cases of ADR,there were 391 male (48.09%) and 422 female (51.91%). Patients aged more than 60 were with high inci-dence of ADR,involving 347 cases(42.68%). Among routes of administration,most ADR cases were caused by intravenous ad-ministration,involving 747 cases (91.88%). Among all drug types,the number of ADR cases caused by anti-infective drugs was the most,involving 382 cases(46.99%);cephalosporins took up the highest proportion,being 38.22%(146 cases). Organs or sys-tems involved in ADR were mainly skin and its appendants,involving 434 cases (53.38%). CONCLUSIONS:ADR monitoring should be strengthened for elderly patients receiving anti-infective drugs intravenously so as to reduce the occurrence of ADR and guarantee medication safety.