Objective: To study the effects of retinoids (retinol? retinoic acid? retinyl acetate) in vitro on the production of interleukin 1 (IL-1)? interleukin 2 (IL-2) of peripheral blood mononuclear cells (PBMC) from the children with recurrent respiratory infection (RRI). Methods: The activities of IL-1? IL-2 of the PBMC from RRI children and the changes of IL-1? IL-2 activities after cultured with 10 -9 mol/L retinoids were measured. Results: The activities of IL-1? IL-2 of PBMC from RRI children were lower than normal control and could be restored to normal level after cultured with retinoids. Conclusion: The production of IL-1? IL-2 of PBMC from RRI children can be enhanced by retinoids and restored to normal.

0.5).The above results show that feeding regime has significant influence on Zn nutriture but not on Cu nutriture. The Zn nutriture of breast-fed infants is superior to that of bottle-fed infants due to better bioavaila-bility of Zn in human milk.The Cu nutriture in early infancy may depend mainly on the fetal storage of Cu in tissues and its mobilization afterbirth.

The concentrations of serum lipids, lipoproteins and apoprotein AI, B100, CⅡ and CⅢ are determined in 32 obese children and age- and sex-matched healthy children. This study aims: 1. to know whether obesity can affect the levels of serum lipids and apoproteins. 2. to understand the correlation between degree of obesity and serum lipids and apoproteins. 3. to study the mechanism of change of serum lipids. In obese subjects, the levels of HDL-C, APO-AI, HDL-C/TC and APO-CⅡ/CⅢ decreased significantly and are negatively correlated to degree of obesity. The levels of TG, VLDL-C, APO-B100, APO-CⅡ and atherosclerosis index increased significantly and are positively correlated to degree of obesity. The levels of cholesterol, LDL-C and APO-CⅡ revealed no change. Multiple correlation analysis showed that TSFT was closely related to HDL-C, STR was closely related to VLDL and APO-C Ⅱ/CⅢ. The mechanism of change of serum lipids and apoprotein is disscused. These results suggest: 1) Obesity can affect the levels of serum lipids and apoproteins. 2) The change of apoprotein and regional fat distribution is a major cause of change of serum lipids. 3) Obese children are at risk to atherosclerosis.