AIM: To study the quality standard for Xingnaojing Injection (Moschus, Borneolum Syntheticum, Fructus Gardeniae, Radix Curcumae). METHODS: Two main components, muscone and bornel, were determined by HPLC and GC, respectively. RESULTS: The average recoveries were 98.3%( RSD was 0.41% , n=3 ) for muscone and 97.7%( RSD =0.54%, n=3 ) for borneol, respectively. CONCLUSION: The method is available with a good reproducibility and can control the quality of this preparation effectively.