1.Effects of chronic EECP on protein expression in thoracic aorta endothelial cells in porcine with hypercholesteremia
Xiaolin CHEN ; Xiaohong HE ; Yan ZHANG ; Yuetao QIAN ; Luguang LIANG ; Dianqiu FANG ; Dengyang ZHAN ; Zhensheng ZHENG ; Hong MA ; Kuijian WANG
Chinese Journal of Pathophysiology 2000;0(10):-
AIM: To explore the effect of chronic enhanced external counterpulsation(EECP) on the protein expression in thoracic aorta endothelial cells in porcine with hypercholesteremia by proteomic techniques.METHODS: After performed EECP for 36 h on the hypercholesteremia porcines,the endothelial cells(ECs) were collected from the thoracic aorta and analyzed with proteomic techniques.RESULTS: Six kinds of protein were detected in ECs in the EECP group,but not in the hypercholesteremia control group.CONCLUSION: Chronic EECP may protect ECs against damage resulted from hypercholesteremia by regulating protein expression in artery ECs,subsequently improving cell adhesion and intracellular lipid metabolism and reducing ECs apoptosis.
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