OBJECTIVE:To observe therapeutic efficacy and safety of prednisone acetate combined with leflunomide in the treatment of IgA nephropathy. METHODS:80 patients with IgA nephropathy were randomly divided into observation group and control group,with 40 cases in each group. Control group was given prednisone acetate 1.0 mg/kg,qd,6 weeks later,decreasing gradually,decreasing to 0.5 mg/kg in 12th week;observation group was additionally given leflunomide 50 mg,qd,3 days later de-creasing to 20 mg. Both groups were given 3 months of treatment. Clinical efficacy,24 h urinary protein quantification,Scr and BUN levels were observed in 2 groups after treatment,and ADR were recorded during treatment. RESULTS:Total effective rate of observation group(95.0%)was significantly higher than that of control group(75.0%),with statistical significance(P<0.05). Af-ter treatment,24 h urinary protein quantification,Scr and BUN levels of observation group were significantly lower than those of control group,with statistical significance(P<0.05). The incidence of ADR in observation group(0)was significantly lower than in control group(7.5%),with statistical significance(P<0.05). CONCLUSIONS:Prednisone acetate combined with leflunomide has significant effect on IgA nephropathy,and will not increase the occurrence of ADR.

Objective To investigate the clinical efficacy of hydrogen-rich water (HRW) combined with oxycodone hydrochloride controlled-release tablets (OHCT) in the treatment of malignant neuropathic pain (MNP) patients.Methods Eighty MNP patients were randomly divided into two groups:OHCT group (group A,n =40) and HRW combined OHCT group (group B,n =40).The visual analog scale (VAS) score,frequency of pain outbreaks,pain relief rate,average dose of OHCT per day,and adverse reactions were observed.Results The VAS scores and frequency of pain outbreaks in groups A and B were significantly reduced after treatment (P ＜0.05).Compared to group A,the VAS scores,pain relief rate,outbreak pain and average dose of OHCT per day in group B were significantly improved after 14 and 28 days of treatment (P ＜ 0.05),and the adverse reactions,such as constipation,nausea and vomiting,in group B were significantly less than those in group A (P ＜ 0.05).Conclusions HRW combined with OHCT can effectively improve the MNP,and reduce average dose of OHCT per day and adverse reactions.

Objective: To explore the relation between self-esteem and mental health of normal college students.Methods: 386 normal college students finished the Self-esteem Scale(SES),Symptom Checklist 90(SCL-90),Self Consistency and Congruence Scale(SCCS) and College students' Behavioral Inhibition Scale(CBIS).Results: There was close relationship between self-esteem and mental health;those students with high self-esteem had more self consistency and congruence,less symptomatic and behavior inhibition.Conclusion: It indicates that self-esteem can effectively predict mental health for normal college students.

Objective: Self-enhancement is a kind of motive that urges people to attend exclusively to the positive aspects of himself,it is so intense that individuals even tend to distort the threatening information to some degree so that they can maintain a positive self-view. This research is to investigate the pattern of self-enhancement of Chinese people. Methods: Self-enhancement was measured by requiring participants to make self attribution as well as other attribution of their success and failure on eight factors. Results: There existed strong self-enhancement motive in Chinese individuals. Specifically,Chinese undergraduates attribute their success to inner factors such as personality and effort. This trends also evident in the conditions in which participants were asked to speculate the attribute pattern of other people like his/her mother on their own success and failure. Conclusion: Chinese undergraduates tend to enhance the self-image in other people's eyes.

Objective: To investigate the rural middle school students' mental health and explore its determinants. Methods: 989 rural middle school students in Jiangxi province were investigated with SCL-90, Social Support Rating Scale and the Chinese versions of EMBU. Results: The major problem of mental health were interpersonal sensitivity, obsessive-compulsive, depression, hostility and paranoid ideation. There was remarkable difference between boys and girls, senior and junior high school students. Multiple regression analysis indicated that the major determinants of the rural middle school students' mental health were subjective social support, usage of social support, father's and mother's rejection and denying, father's over-protection, mother's punishment and rigidity, different sex, grades and only children or non-only children. Conclusion: The students in rural middle school, especially in senior high school, had severe mental health problems, social support and parental rearing patterns have a significant influence on mental health.

Abstract： Objective　To comprehend the gastroenteritis outbreak triggered by sapovirus (SaV) in a middle school located in Chaozhou City in 2022, ultimately providing a scholarly reference for the implementation of preventive and control measures against contagious diarrhea within educational institutions. Methods　Descriptive epidemiological methods were employed to analyze the epidemiological characteristics of the outbreak. A 1∶3 case-control study was conducted to identify potential correlation factors. Anal swab specimens from students and kitchen workers, food samples from the cafeteria, and environmental swab samples were collected for nucleic acid PCR testing of Sapovirus, Norovirus, Staphylococcus aureus, five types of enterotoxigenic Escherichia coli, Salmonella, and Bacillus cereus. One SaV-positive nucleic acid sample was randomly selected for VP1 capsid protein sequencing. Results　A total of 148 sapovirus cases and 6 asymptomatic infections were reported in this outbreak. The predominant clinical manifestations were vomiting (83.1%), nausea (38.5%), and vertigo (24.3%), with no fever symptoms reported. The peak incidence was recorded on March 20, showing a propagative and point source exposure pattern. Cases were distributed across 83.3% of the classes in the school, with the highest incidence rate of 32.69% in Class 311. The case-control study revealed that having lunch on campus on March 18 was a significant correlation factor for the disease (OR=4.17, 95%CI: 1.58-11.00). A total of 43 students and 23 kitchen workers anal swab specimens, 7 food samples, and 9 cafeteria environmental swab samples were collected. Of these, 20 students and 6 kitchen workers anal swab specimens tested positive for SaV nucleic acid, while the remaining samples returned negative results. Gene sequencing indicated the presence of the GI.6 genotype. Hygiene investigation exposed improper food handling practices among some kitchen workers. Conclusions　This outbreak was caused by a GI.6 genotype SaV infection, with exposure in the cafeteria on March 18 being the primary contributing factor for the outbreak and subsequent spread.

Objective To study the effect of dexmedetomidine in the functional endoscopic sinus surgery (FESS) on the recovery period of general anesthesia. Methods Fifteen min before the end of surgery, 40 FESS patients were treated with intravenous infusion of dexmedetomidine at 0.6μg/kg. The occurrence of cough response, degree of pain and agitation in patients were observed. Result The response score of choking cough of the patients with intravenous infusion of dexmedetomiindine was (1.2 ± 0.5), the score of VSA was (1.9 ± 0.5), and the degree of agitation was (1.2 ± 0.4). Conclusion For those undergoing FESS, postoperative use of dexmedetomidine 15 min before the end of surgery, can not only have an effective effect for reducing the incidence of choking cough and agitation and but also decrease the pain degree so that the patients can live through the general anesthesia recovery period.

Objective By analyzing the monitoring data and the outbreak of brucellosis in Qingyang City in 2014,to provide a epidemiological evidence for prevention and control of the disease.Methods According to the requirements of Gansu Province Human Brucellosis Surveillance Program and Qingyang City Human Brucellosis Surveillance Program,we implemented epidemiological investigation in the high-risk group of brucellosis in 40townships under the jurisdiction of 8 countries in Qingyang.Detailed information on subject's exposure with livestock,clinical symnptoms and incidence were asked and recorded.Venous blood samples of 3-5 ml of suspected cases were collected.Then the rose bengal plate agglutination test (RBPT) was used to test the separated serum,and the standard tube agglutination test (SAT) was used to test the serum sample of positively infected person in the laboratory.Our test methods and results were in accordance with the implementation of Criteria for the Diagnosis of Brucellosis(WS 269-2007).For identified outbreaks,appropriate actions were taken based on regulations in the Brucellosis Prevention Manual.Results In 2014,we inspected 9 498 people in the whole city,implemented epidemiological investigation and collected 1 673 blood samples.Three hundred and thirty-eight samples were positive for RBPT.The infection rate was 20.20％ (338/1 673).Also there were 260 SAT positive samples (1 ∶ 100 ++above).The positive rate was 15.54％ (260/1 673).Combined with clinical symptoms,260 cases were confirmed (241cases were newly made and 19 cases were primary).The prevalence rate was 2.74％ (260/9 498).There were 12cases in total in outbreak points (2 cases in Huachi,3 cases in Huanxian,5 cases in Heshui,1 case in Qingcheng,and 1 case in Zhenyuan).Our epidemiological survey included 1 270 people,and we collected 308 blood samples.Fifty-one presented positive results for RBPT.The positive rate was 16.51％ (51/308);50 presented positive results for SAT.The positive rate was 16.23％ (50/308).Fifty cases were confirmed cases in the outbreak,all of which were new cases of this year,and the incidence was 3.94％ (50/1 270).Conclusions Brucellosis epidemic in Qingyang City has begun to rebound obviously,at the same time the outbreak points increased significantly.Both of which should capture the authorities' attention.The local government is supposed to undertake the due obligations to strengthen prevention and make efforts to control the spread of brucellosis.

Objectives:To investigate the impact of doctor-attacking on medical students’ occupation atti-tude. Methods: We conducted a sample survey towards different major of Wenzhou Medical University by using self - made questionnaire. Reults: The occupation attitude of interviewee is not so bad, the confidence about the occupation is really deep down and the occupational sense of mission worries a lot of people. Doctor-attacking cases damage the honorable sense of occupation, even threatens basic personal security. The spread passive emotion by Network media , as well as the varied choices of occupations, expand the influence of hospital violence. Conclusions: The fre-quent occurrences of doctor-attacking cases weaken the occupational attitude of medical students and became the obstruc-tion to be a doctor,countermeasures should be taken from multiaspect of society,media,schools and teachers through a va-riety of ways.

1 1 patients with moderate or severe crowding in the anterior arch were treated with 4 premolar extraction.After canine distaliza-tion first approach,the teeth were aligned and leveled.The results of the study suggest that,with strict implementation of indication,this method may be a viable treatment for the moderate or severe crowding anterior.