No abstract available.
Demyelinating Diseases*

Electrodiagnostic features are particularly useful in distinguishing chronic acquired demyelinating neuropathy from familial demyelinating neuropathy. The electrodiagnostic findings in patients with familial demyelinating neuropathy reveal uniform slowing of NCV (nerve conduction velocity) in all the segments of nerve without conduction block. In contrast acquired group shows nonuniform slowing of NCV with temporal dispersion of CMAP (compound muscle action potential) on proximal stimulation. In addition conduction block is noted in some of acquired patients. We experienced 2 patients from one family with HSMN type I, who showed conduction block and concluded that differentiation between chronic acquired and familial demyelination neuropathy is not possible with conduction block alone in a substantial number of patients.
Demyelinating Diseases ; Humans

No abstract available.
Demyelinating Diseases ; Hyponatremia

Optic neuritis refers to all inflammatory diseases in the optic nerve. The most common type is demyelinating optic neuritis. Biomarkers can indicate its pathophysiological process and thus are useful in disease diagnosis and treatment. This article reviews the known biomarkers for demyelinating optic neuritis.
Biomarkers ; Demyelinating Diseases ; Humans ; Optic Neuritis

Inflammatory demyelinating diseases are usually diagnosed based on characteristic clinical and radiological findings. However, some demyelinating diseases have been presented as growing large mass-like lesions, and it is difficult to differentiate those demyelinating lesions from brain tumors. We report three cases of demyelinating diseases mimicking brain tumors. These cases suggest that the inflammatory demyelinating diseases have a wide spectrum and they can present with the same radiological features of brain tumors.
Brain Neoplasms* ; Demyelinating Diseases* ; Multiple Sclerosis

No abstract available.
Brain ; Brain Neoplasms ; Demyelinating Diseases ; Multiple Sclerosis

Biopsies of suspected lymphoma cases with history of pre-biopsy corticosteroid therapy present several diagnostic issues, such as the inability to demonstrate the neoplastic hematolymphoid cells, the similarity of post-corticosteroid changes with inflammatory demyelinating lesions, and the possibility of a demyelinating lesion preceding a central nervous system lymphoma. This report presents the case of a 51-year-old immunocompetent male with a solitary callosal mass, with immunomorphologic features suggestive of a demyelinating lesion on initial biopsy, and upon re-biopsy after three months revealed a diffuse large B-cell lymphoma. Awareness of these issues in post-corticosteroid stereotactic biopsy specimens, together with adequate clinical and radiologic data, is important for proper diagnosis and further therapeutic guidance.
Adrenal Cortex Hormones ; Demyelinating Diseases ; Lymphoma

Background: There is supportive evidence that multiple sclerosis (MS) could potentially affect the peripheral nervous system. We assessed peripheral sensory and motor nerve involvement in patients with MS by a nerve conduction velocity test. Methods: We studied 75 patients who had a relapsing-remitting or secondary progressive pattern. We measured amplitude, latency, conduction velocity, Hoffmann reflex (H-Reflex), and F-Waves. Results: The amplitude of the right tibial, right proneal, left tibial, left proneal, and left median motor nerves was less than the mean for the normal population. Right ulnar sensory conduction in the patients showed an amplitude that was less than that of the normal population; there was no significant change in the amplitude of other sensory nerves. Latencies of the right and left median and right proneal motor nerves and left ulnar sensory nerves were statistically less than that of the normal population. Mean motor conduction velocity and F-wave conduction did not differ significantly from the normal population. H-reflex latencies of the right and left lower limbs were significantly more prolonged than those of the normal population. Conclusion: Our results suggest possible peripheral motor nerve abnormalities in MS patients, especially with the amplitude of the motor nerves; however, our results do not demonstrate any significant difference among the nerve conduction velocity parameters of sensory nerves between MS patients and the normal population.
Demyelinating Diseases ; Multiple Sclerosis ; Peripheral Nervous System Diseases

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) represents an important acquired condition characterized by progressive, symmetrical, proximal and distal weakness. CIDP is characterized by sensory loss and weakness, areflexia, elevated CSF protein and electrodiagnostic evidence of multifocal demyelination with or without superimposed axonal degeneration. Some reports are made that an antecedent illness in the weeks preceding the onset of symptoms such as upper respiratory syndrome or flu-like illness, gastrointestinal syndrome etc., but intestinal pseudoobstruction as the main clinical feature in CIDP is an uncommon finding. The clinical course is variable. The condition is responsive to immunosuppressive therapy, especially prednisone and plasma exchange. We report a case of intestinal pseudoobstruction secondary to CIDP diagnosed by clinical features, electrodiagnostic study and nerve biopsy pathology.
Axons ; Biopsy ; Demyelinating Diseases ; Intestinal Pseudo-Obstruction* ; Pathology ; Plasma Exchange ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating* ; Prednisone

Acute disseminated encephalomyelitis(ADEM) is an uncommon acute inflammatory disease of the CNS which follows viral infections or Vaccination. ADEM is thought to be an immune mediated disease. The classic featues of ADEM include an antecedent event, commonly a viral illness, followed after a latent period by acute onset of multifocal or diffuse CNS signs, the potential for extensive or even complete recovery, and pathologic evidence of perivascular inflammation and demyelination. We experienced a 43-year-old patient with ADEM and reviewed literatures.
Adult ; Demyelinating Diseases ; Encephalomyelitis, Acute Disseminated* ; Humans ; Inflammation ; Vaccination