Objective To evaluate the clinical efficacy of laser-assited subepithelial keratomileusis(LASEK) for treatment of myopia and astigmatism.Methods LASEK was performed for 30 cases(60 eyes) with myopia and astigmatism.The preoperative myopia diopter ranged from -1.50DS to -11.00DS,the astigmatism ranged from -1.50DC to -2.50DC.To make corneal subepithelial valve,eyes were soaked in 20% alcohol for 30 to 35 seconds.It was applied with quasi-molecule laser system.Results The visions with 73.17% were between 0.8 and 1.0 one month post-operatively,26.55% between 0.5 and 0.7,and 0.27% less than 0.5;The average visions with 76.69% were between 0.8 and 1.0 three months post-operatively,and 23.30% between 0.5 and 0.7;The visions with 77.78% were between 0.8 and 1.0 in six months after operation,and 21.68% between 0.5 and 0.7.There were no significant difference between in three months post-operatively and preoperative in corrected visions.Conclusion LASEK induces less pain and HAZE than PRK and LASEK has wider surgery field.Moreover,the risk of LASEK has less risk and less hidden danger than LASIK.In summary,LASEK is one of the safe choices in the treatment of myopia with laser relatively.