Objective To observe the clinical effect , blood glucose time , clearance time of ketone body , correction time of acidosis and influence on average daily dosage of insulin of supplementing Qi and nourishing Yin combined with insulin treatment of patients with diabetic ketoacidosis (DKA).Methods 67 cases of DKA were divided into 2 groups.Control group (n=32) was giv-en micro injection of pump continuous infusion of insulin and aggressive fluid resuscitation for potassium supplement , water and elec-trolyte maintaining and acid -base balance;the observation group ( n=35 ) was given oral Chinese medicine for supplementing Qi and nourishing Yin on the basis of control group .The clinical effect after treatment , blood glucose time , clearance time of ketone body, correction time of acidosis , average daily dosage of insulin and the average number of hypoglycemia per capita were compared and analyzed .Results Blood sugar could be controlled faster in observation group .Clearance time of urine ketone and correction time of acidosis were significantly shortened .The dosage of insulin and number of hypoglycemia per capita were greatly reduced .There were significant differences compared with the control group (p<0.01);in terms of clinical effect, 19 cases of observation group were markedly effective , 14 cases effective , and 2 cases ineffective with the efficiency rate of 94.29%; 13 cases of control group were markedly effective , 10 cases effective , and 9 cases ineffective with the efficiency rate of 71.88%.There were differences between the two groups (p<0.05).Conclusion Supplementing Qi and nourishing Yin can significantly improve the curative effect in the treat -ment of DKA .

Objective To investigate the expressions of platelet activation-dependent granule membrane protein and platelet-derived growth factor receptor-αB, and the ultra-microstructure changes of platelets in patients with acute ST-segment elevation myocardial infarction(STEMI). Method The expressions of platelet activationdependent granule of glycoprotein (CD62P)and platelet derived growth factor receptor αβ subtype (PDGFR-αβ)of platelets in peripheral blood in 36 patients with acute ST-segment elevation myocardial infarction(STEMI) hospitalized and another 34 healthy subjects over the same period (control group) were investigated by flow cytometry and data were analyzed. The changes of ultra microstructure and activity of blood platelets in those patients and control group were observed under the scanning electron microscope. Results The expressions of CD62P and PDGFR-αβin patients with STEMI group before treatment were (3.65 ± 1.87) % and (0.43 ± 0.39) %, respectively, and those after treatment were (0.96 ± 0.79) % and (0.28 ± 0. 24) %, respectively, whereas those in control group were (0.67 ± 0.35) % and (0.27 ± 0.22) %, respectively, which were much lower in control than those in patients with STEMI before treatment (P ＜ 0.01 or P ＜ 0.05) respectively. There were statistically significant differences in the expressions of CD62P and PDGFR-αβ in patients group between pre-treatment and posttreatment (P ＜0.01 or P ＜0.05), respectively. Obvious ultra-microstructure changes of platelet surface in patients with STEMI group were observed. Conclusions Due to platelet activation in AMI, the expressions of CD62P can be used as effective indicators for monitoring coronary heart disease, and the PDGFR-αβ can be used as a reference indicator. The platelet surface ultra-microstructure changes during platelet activation in patients with AMI can be found by scanning electron microscopy.

Objective To explore the correlation of comorbitidy status and life quality in coronary disease ( CD) patients by the cumulative illness rating scale ( CIRS) and Europe health-related quality of life questionnaire -5 Dimension (EQ-5D). Methods A total of 212 CD patients, who hospitalized in Department of Cardiovascular over one week and had over level one care as the survey objects, applied CIRS and EQ-5D, documented biochemical norm, days of hospitalization and expenditure, and were analyzed the correlation between comorbitidy status and life quality. Results The CD patients stayed a serious status of cormorbitidy, distributed in different system and was reduced quality of life. The total score of CIRS was (20. 36 ± 6. 36) when admitted, severity norm was (1. 45 ± 0. 45), comorbitidy norm was (6. 59 ± 2. 23), while total score of EQ-5D was (10. 83 ± 2. 86), in which VAS was (44. 29 ± 23. 17) score. Different level of CIRS patients, there were statistically significant on EQ-5D, VAS, days of hospitalization, and expenditure (P<0. 01). After one week admission, the low score of CIRS patients had more people change to level two care with statistical significance (P<0.01). The score of CIRS had positive correlation with EQ-5D, days of hospitalization, expenditure, fasting blood glucose and serum creatinine, and negative correlation with VAS (r=0. 842,0. 802, 0. 292,0. 148,0. 323,-0. 531;P<0. 05). Conclusions The comorbidity status has negative correlation with life quality in CD patients, and the CIRS can assess the severity of comorbidity status objectively.