Objective To observe the effects of multidisciplinary therapy on central pain of patients with spinal cord injury.Methods 32 cases of spinal cord injury with central pain were treated with accupuncture, massage and drugs, and the effects were assessed by McGill Pain Questionnaire (MPQ), Visual Analogous Score (VAS) and Barthel Index (BI).Results The scores of pain of all patients significantly decreased and the scores of BI highly increased after treatment (P<0.01).Conclusion Multidisciplinary therapy is effective on central pain in patients with spinal cord injury.