1.A Study on the Catabolism Degradation of Collagen in Hypertrophic Scar
Zongyao WU ; Jixiang WU ; Hongliang LIU ; Qin WANG ; Qing YIN ; Dehuai WANG
Chinese Journal of Rehabilitation Theory and Practice 1999;5(1):6-8
Purpose: To understand the function of catabolism degradation in the formation and deterioration of hypertrophic scar. Method: The study was carried out clinically, on animal model and cultured fibroblast cell. The investigation was conducted with naked eye, microscope, situ hybridization, dot blot hybridization, TUNEL and immunohistochemistry. Result:①The hypertrophic scar grew up very slow but might be eliminated 1/3 to 2/3 within one month with different chemical intervention. ②The synthesis of collagen in hypertrophic scar increased a little, but it's degradation decreased much more. ③The collagenase MMP-1 could destroy the collagen after local injection into the hypertrophic scar, it was proved by light and electromicroscope. ④The expression of MMP-1 Mrna increased a little in hypertrophic scar, but MMP-1 in the scar really decreased in quantity and activity. ⑤Ch-4-S increased significantly in hypertrophic scar, it wrapped up the collagen fibrils and blocked its contact with and avoided its catabolism by MMP-1.TIMP increased in hypertrophic scar and depressed the activity of MMP-1. ⑦The expression of TGF-β increased significantly. It positively related with the expression of TIMP and negatively related with the apototic phenomena in hypertrophic scar. The fibroblast in hypertrophic scar was rich and active, but its proliferation was not elevated and apotosis was delayed. Conclusion: ①The delay of apotosis of fibroblast, the wrapping of collagen by Ch-4-S, the reduction of collagenase in quantity and activity together made the abolition of collagen decreased and might be primary for the formation of hypertrophic scar. ②Accelerating the apotosis of fibroblast and catabolism of collagen might be an easy and rapid way for prevention and treatment of hypertrophic scar.
2.Xinxibao for the treatment of chronic bacterial prostatitis.
Dehuai LIAO ; Zhiguang CHEN ; Zhennong DENG ; Donghui WANG
National Journal of Andrology 2004;10(9):676-677
OBJECTIVETo study the effect of Xinxibao as a supplementary drug in the treatment of chronic bacterial prostatitis (CBP).
METHODSEighty-one cases of CBP were divided into two groups: Group A (n = 38), treated with Xinxibao combined with sensitive antibiotic, and Group B (n = 43), treated with sensitive antibiotic only. Contrast studies were made on the therapeutic effects in the two groups, and the results were analyzed.
RESULTSThe effectivity rate was significantly higher in Group A than in Group B.
CONCLUSIONXinxibao can effectively relieve the symptoms of CBP.
Adolescent ; Adult ; Anti-Bacterial Agents ; therapeutic use ; Bacterial Infections ; drug therapy ; Chronic Disease ; Humans ; Male ; Metalloproteins ; therapeutic use ; Microbial Sensitivity Tests ; Middle Aged ; Prostatitis ; drug therapy ; microbiology ; Zinc ; therapeutic use
3.Exploring the Intellective Apparatus for Measuring the Intensity of Pressure on Dermal Sears
Yu ZHONG ; Hong LI ; Dafu CHEN ; Dehuai WANG ; Zhiyong HUANG ; Wenhua LIU ; Dingming ZHANG ; Peng LUO ; Xiao WANG ; Wei ZHAO ; Jianwen ZHOU
Chinese Journal of Medical Physics 2010;27(1):1641-1644
Objective:To explore the method of measuring the intensity of pressure on dermal scars.Methods:The testing inductor to taste intensity of pressure (being forced by such as elastic bandages enswathements ,etc.) was by way of the pressing transducer.The pressure signal (degree mv) of the transducer was magnified and transferred to tiny controls where A/D switch happened.All of processions were accomplished by soft wares of C language and results were displayed by LED.Results and Conclusions:The apparatus can measure the intensity of pressure basing on different intensities (such as kgf/cm2 or mmHg or kPa,etc).The results were credible and the operations were simple.