Objective To investigate the role and value of the biliary stent in the treatment of large common bile duct stones. Methods Thirty-two patients with large common bile duct stones were underwent plastic biliary stenting after endoscopic stone extraction with oddi sphincterotomy, and were followed up for 6 months. Results Thirty-two patients were successfully placed biliary stents. The postoperative jaundice, abdominal pain and other symptoms were alleviated. The secondary endoscopic retragrade cholang iopancreatography (ERCP) was performed six months after surgery. Large stones disappeared in 3 cases, 25 cases were reduced to varying degrees, 4 cases showed no obvious narrowing in 32 patients with biliary stones. Twenty-nine patients with residual stones were taken stone again. The operation was successful in 25 cases . Four cases continued to be observed the drainage of biliary since the difficulties for taking stone. The success rate of treatment of large common bile duct stones by biliary stent was 87.5%. Conclusion The therapy of large common bile duct stones by biliary stent is of simple, short operation time, fewer complications, satisfactory results, safe and effective advantages.

AIM: To study on antisense oligoncleotides as inhibitor of human acute promyelocytic leukemia (HL-60) proliferation and C-myc protein expression. 　METHODS: Oligonucleotides with different lengths (18-21 mer) complementary to the definite regions of C-myc mRNA, modified groups (with S replaced O in internucleotide phosphate linkage) and unmodified ones (with natural internucleotide phosphate linkage) were designed and synthesized. These olignucleotides were tested for their activity on HL-60 cell and also for their toxicity on normal lymphatic cells of human. 　RESULTS: It was found that two of the oligonucleotides complementary to 5′-44-61 and 5′-556-576 the regions of C-myc mRNA exhibited great inhibitory effects (59.5 % and 62.7 %) on growth of HL-60 cells for a definite time. And no toxicity of the two antisense oligonucleotides was found on normal lymphatic cells of human. 　CONCLUSION: The sequence of antisense oligonucleotides complementary to 5′-44-61 of C-myc mRNA was designed newly by us may be turned into inhibitory medicine of HL-60 cells.

This paper aimed to review the recent literature on the TCM treatment for stroke sequelae. The content summarized and discussed the definition of stroke sequelae, herbalmedicine, TCM patents, acupuncture and so on. Sequelae of stroke’s pathogenesis was mainly caused by deficiency generating stasis, so the treatment principles were to tonifying Qi and blood and promote circulation and remove stasis with the common prescriptions, such asBuyang-Huanwudecoction,Xuefu-Zhuyu decoction andDihuang-Yinzi. Meanwhile, Chinese medicine patents and acupuncture treatment canimprove the brain function and ADL.