A prospective study on a new antibictic antineoplastic drug Epirubicin (pharm-orubicin,EPI)in the management of malignant tumors was carried out from February 1987 to February 1990.Diseases divided into three groups, ( 1 ) 47 cases, recurrences/metastases of the initial tumor, after treatment of operation, radiation or other antineoplastic drug; (2)8 cases, after palliative operation; (3)15cases, after radical operation.The response rate was 92.9% for maligcant lymphoma. The EPI containing regimens were also effective in the patients with gastre-intestinal cancer, breast can- eer and sarcoma, etc. The main side effectsof EPI containing regimens were also analysed, and the dose-limiting toxicity was still bone marrow depression. Only one patient showed I A-V block. Tie role of EPI in chemotherapy of common malignancies was discussed

With a spreader and improved Luque's Rod segmental fixation, operative reduction for thoraco-lumbar fracture was conducted in 60 cases of theoraco-lumbar fracture-dislocation concomitant with paraplegia. The procedure is helpful to rehabilitation exercises and the reault is satisfactory. The mechanical condition on Luque's Rod and vertebra complex and antideformity mechanism of the improved fixation has been analysed to study the merits of this new proceedure. The improved Lugue's Rod fixation was compared with the original one in the facture of thorac-lumbar spine.

Fogarty balloon catheters have been widely used in vascular surgery, But no such products have been manufactured in China yet. The Department of Surgery of this hospital in cooperation with Chongqing Changjiang Rubber Plant has successfully developed the batch of China-made Fogarty balloon catheter, Exporime-ntswere performed on 14 dogs to investigate the acute damage to arterial and venous walls. The results indicated that the damage was slight. Therefore, we consider that the China-made Fogarty balloon catheter can be safely used in the clinic

Objective　To study the relationship between cell apoptosis and vascular disease.Methods　The paper reviewed the concept, character, gene control and signal transduction of apoptosis associated with vascular disease.Results　Cytokine, radiation could induce apoptosis of endothelial cells, and caused vascular damage.The apoptosis of smooth muscle cells was related to the atherosclerosis and restenosis of vessels.Conclusion　Cells apoptosis is related to vascular disease significantly.

Objective To investigate the inhibitory effect of appling slow-releasing triptolide on adventitia on the intima hyperplasia of autologous vein graft.Methods In 24 male New Zealand rabbits, external jugular vein to common carotid artery models were established, and then were divided into 3 equal groups at random: blank-control group, receiving no management on adventitia of the vein graft; F-127 control group, receiving local application of 0.5 mL of 20 % F-127 on adventitia of the vein graft; experiment group, receiving local application of 0.5 mL of 20 % F-127 containing triptolide 300?g. Vein graft specimens were harvested at 2 weeks after the operation. Histomorphologic methods were used to detect the degree of intima hyperplasia of the specimens. The expression of bcl-2 and Fas of the specimens was detected by immunohistochemistry. The apoptosis vascular smooth muscle cells (VSMC) were detected by TUNEL.Results Two weeks after vein grafting, compared to blank-control group and F-127 control group, intima hyperplasia of experiment group [intima thickness (29.9?7.6)?m, I/M 0.56?0.08] was markedly inhibited (P

ObjectiveTo introduce the effect of trifoil peptides on the protection and treatment of gastrointestinal ulcer(GIU). MethodsWe reviewed literatures about trifoil peptide in its structure, distribution, physiologic effect and mechanism, and its relation with GIU. Results Trifoil peptides formed a layer of mucus glue by combining with glycoprotein ,and improved the defense ability of the gastrointestinal(GI) mucosa .Trifoil peptides repaired the GI mucosa by abjusting the movement of mucosal cells. Trifoil peptides also had the effect of antiproliferation and antiapopotosis. There was an ulcer-associated cell lineage (UACL) around GIU. In GIU, trifoil peptides unusually expressed new cells coming from UACL moved to the surface of ulcer, and repaired the ulcer. UACL can express three trifoil peptides.Used before and after the experiment, trifoil peptides have the protective and therapeutic effect on the experiment gastroenteric ulcer. ConclusionsTrifoil peptides may offer a new method to prevent and treat GIU.

Objective To introduce the effect of estrogen on the vascular endothelial cells and on the development of Buerger's disease. Methods The relative papers were summarized with and made a literature reviewing. Results The physiological level estrogen in vivo has protective effects on the vascular endothelial cells; however, the high level of estrogen in vivo can hurt the vascular endothelial cells,which is an important factor in the development of Buerger's disease. Conclusion Investigation of the mechanism of high level of estrogen in Buerger's patients would have a favor effect on the prevention and treatment of Buerger's disease.

Objective To explore the relationship between nuclear factor ?B (NF ?B) and the occurrence, metastasis, and treatment of colon cancer. Methods The literature on the structure and the property of molecular biology of NF ?B, the relationship between NF ?B and apopotosis, malignant tumor and colon cancer were reviewed.Results NF ?B had action of antiapopotosis. The occurrence of malignant tumor had close relation with the oncogene by NF ?B, the metastasis of malignant tumor was that cell of cancer escaped the killing and supervising of immunity by NF ?B. NF ?B affected the occurrence and metastasis of colon cancer by regulating c myc, Cox2, ICAM 1.Conclusion NF ?B has important action in the occurrence and metastasis of colon cancer. It will become a new target of treatment.

Objective To retrospectively analyze the risk factors of recurrent groin hernia. Methods Data came from all hernia repairs recorded in our hospital between 1991 and 2001. A total of 1 082 cases of groin hernia was analyzed through Cox proportional hazard model to determine the relative risks between recurrence and mode of admission, types of groin hernia, repair methods (traditional/tension free hernioplasty), and post operative complications.Results From 1991 to 2001,1 082 groin hernia operations were performed in our hospital, 88.9% for primary hernia and 11.2% for recurrent hernia. As compared with traditional hernia repair methods, Lichtenstein’s tension free hernioplasty technique had less relative risk for recurrent hernia repair than that for primary hernia repair. Postoperative complications and indirect hernia were linked to an increased relative risk for recurrence. Conclusion There are many factors affecting the recurrence of inguinal hernia, but the use of tension free hernia repair may decrease re recurrence of recurrent hernia.

Objective To review experimental study and clinical application of materials to bile duct repair and reconstruction.Methods Comparison of different materials was made between advantages and disadvantages.Results Synthetic grafts such as vitallium,teflon are easy to handle,but have no flexion,and have foreign body reaction.Although autogenous free tissues such as venous patch and peritonium are resistant to infection,they are likley to lead to bile duct stricture because of lacking adeuqate blood supply.Vascularized neibouring tissues for repearing bile duct defect have satisfactory results.Conclusions To avoid bile duct striccture,vary measures should be taken to repair bile duct defecs;for segmental loss of bile duct,end to end anastomosis or Roux-en-Y biliary jejunal reconstruction should be applied.