Objective To study the epidemiological characteristics of measles in Fuyong Street in order to predict its occurrence and reduce its incidence by establishing preventive and control measures.Methods Epidemiological data in Fuyong Street between 2003 and 2007 were analyzed.Results The result showed that 393 measles cases were reported in the whole street during 2003 and 2007,329 were confirmed by laboratory,and 60 were local cases.The measles annual average incidence was 18.29/100 000.The high incidence period was from March to August and the most measles cases were young adults and infants.30.79% cases had no immunization history and 24.68% cases had immunization history.Conclusions The incidence of measles is kept at a high level.It will go on possibly for half a year or a year.A comprehensive control measures should be thaken to strengthen vaccination program especially for foreign people and to reinforce the surveillance and analysis of epidemic situation in order to avoid the outbreak of the disease.

Objective To compare the efficacy and safety of ivermectin with metronidazole in patients with intestinal acariasis.Methods 24 patients with typical intestinal acariasis were selected and divided into two groups,each group had 12 members.Double-blind,randomized clinical trial of ivermectin versus metronidazole was assigned.Results 24 patients completed 3 courses.The total cure rate of ivermectin and metronidazole were 100%(12/12) and 25%(3/12),respectively.There was statistical difference between the two groups(P

Objective:To investigate the neural dendritic spines variation and myocyte enhancer factor 2A (MEF2A) changes in the medial prefrontal cortex (mPFC) and their function in posttraumatic stress disorder (PTSD) mouse models established by single prolonged stress&electric foot shock (SPS&S).Methods:A total of 60 8-week-old male C57BL/6N mice were selected and randomly divided into control and treatment groups ( n=30). PTSD mouse models in the treatment group were established by SPS&S; mice in the control group were deprived of food and water during the modeling process without other stress treatment. Ten mice were taken from each group 14 d after modeling, and anxiety and fear behaviors in mice were evaluated by open field test and elevated plus-maze test; the morphology of mPFC neurons, total length of dendrites and density of dendrite spines were determined by Golgi staining. Five mice were selected from each group one, 4, 7 and 14 d after modeling; real-time quantitative PCR was used to detect the mRNA expressions of Arc and SynGAP in mouse mPFC, and Western blotting was used to detect the proteins levels of MEF2A, P38, phosphorylated- (p-) MEF2A, and p-P38 in mouse mPFC. Results:(1) As compared with those in the control group, the number of times entering the central region was significantly smaller and the total distance of movement was statistically decreased in mice of the treatment group ( P<0.05); as compared with those in the control group, the number of times entering the open arm region was significantly smaller and the proportion of time spending in the open arm region was statistically decreased in the treatment group ( P<0.05). The total length of neurons in mPFC was significantly shorter and the density of dendrites was significantly lower in the treatment group than those in the control group ( P<0.05). (2) The Arc and SynGAP mRNA expressions, and p-MEF2A and p-P38 protein expressions in mPFC of mice in treatment group one, 4, 7 and 14 d after modeling were significantly increased as compared with those in control group ( P<0.05); in treatment group, the Arc and SynGAP mRNA expressions 4 and 7 d after modeling were significantly higher than those one and 14 d after modeling, and p-MEF2A expressions in mPFC 4 and 14 d after modeling were significantly higher than those one and 7 d after modeling ( P<0.05); and p-P38 protein expressions in mPFC 7 and 14 d after modeling were significantly higher than those one and 4 d after modeling ( P<0.05). Conclusion:In PTSD mouse models established by SPS&S, transcriptional activation of MEF2A involves in dendritic spines number reduction in the pyramidal neurons of mPFC.