IntroductionDigestive system diseases are accounted in 4th place of the causes of mortality that are might caused by Mongolian climates and the features of food nutrition. It is a very important to obtain the natural herbal drug which has less side effect, use in medical practice for an appropriated disorder. Therefore we are put an aim of obtain a new drug from Sanguissorba officinalis L. for the treatment of diarrhea. This herbal plant grows in botanical and geographical provinces such as Khangai, Khentii, Khuvsgul, Mongol Daguur and widely distributed in Mongolia. Sanguissorba officinalis L. containes tannin substance up to 20%. Rhizome, herbs, flowers of Sanguissorba officinalis L. are widely used for the Mongolian, Tibetan, Russian, German, Korean, Poland, Hungarian traditional medicine to treat diarrhea, gastrointestinal disorders and haemostatic. This study and research work was done by Pharmaceutical Technology and Management Department of School of Pharmacy, HSUM.GoalThe aim of the study is to solve the problem of technology to obtain a tablet formulation from Sanguissorba officinalis L.Materials and MethodsWe collected and dried the flowers of Sanguissorba officinalis L. in Kherlen soum, Dornod province on August of 2010, 2011 and 2012. Choice of the optimal extragent, suitable extraction method was defined by I.A.Muraviev, U.G. Pshukov methods. The fraction of granules were determined using the method by Kozein, the bulk density of granules was determined method by Lusy Wan Cheng, to obtain tablets used by wet granulation method, to establish quality criteria of liquid extract and tablets by Mongolian National First Pharmacopeia, and the statistic analyses were done by SPSS-17 programme, using t-criteria of Student Fischer.ResultWe had extracted liquid extract from flowers of Sanguissorba officinalis L. and it has been extracted by repercolation method German pharmacopeia modification. The technological parameters of liquid extract are the main important index to calculate the extragent correctly, to establish the material balance exactly, to extract the process efficiently, to develop technological regimentation and to base account of economical benefit. We determined the technological parameters as the optimal extragent is 40% ethanol; the effective extracting method is repercolation method German Pharmacopeia modification. For the development of tablets by wet granulation method from liquid extract using various binders and choose the optimal bender was mix starch and methylcellulose past. Tablets from Sanguissorba officinalis L. was standardized by such criteria, as the amount of biologically active compound, appearance, hardness, friability, average weight, weight variation, disintegration, dissolution, amount of heavy metals and microbiological contamination by Mongolian National First Pharmacopeia.ConclusionThe result of the study was done the technological parameters of liquid extract of Sanguissorba officinalis L. such as the optimal extragent, the effective extracting method. As the result of determining these parameters, it has much practical significance for establishing the technological condition to extract the biological active compounds completely from flowers of Sanguissorba officinalis L. In the result of the study to obtain tablets from fluid extract of Sanguissorba officinalis L. has been developed and the quality criteria has been defined.

Introduction Medicinal plants and herbal drug Introduction Medicinal plants and herbal drugs have made and a tremendous contribution to national health and development from the very beginning. Fora very long time, people have used locally available medicinal plants for medicaltreatment and have eaten certain vegetables and spices for health protection as well as sustenance. Even though in traditional medicine, we use many different medicinal plants and herbal preparations for treatment of various diseases, most of them are not completely studied yet. One of these herbal preparations is Jonsh-6. The research group reported already that the preparation Jonsh-6 has pharmacological effects such as to treat diseases such as gastritis, stomach disorder (B.Uyanga, S.Seesregdorj, 2011) and at this time there aren’t any other studies made in respect to the preparation Jonsh-6. The aim of our research is to complete qualitical and quantitative analyses of biological active substance in the preparation Jonsh-6. Material and methods The contents of the preparation Jonsh-6 are Calcitum-0.3g, Piper longim L- 0.08g, Aucklanda lappa Decne-0,15g, Inula helenium L-0.15g, Carthamus tinctorius L-0.24g, Amomum Kravanh Pierreex Gagnep-0.08g.Analyses of the preparation were studied by using HPLC on Waters Delta 600 Pump, Waters 600 Controller, Waters 2487 DualχAbsorbance Detector, Pinnacle II C18 5μm, 250x4.6 ммand selected following conditions: mobile phase: Acetonitrile:water/50:50,Acetonitrile:0.7% phosphoric acid /25:75,wavelength 210, 338, 403 nm, Detector: UVvis, column: Pinnacle IIC18 5μm (250x4.6 мм), flow rate 1.0 ml/min. Key words: HPLC, Jonsh-6, Safflomin-A, Piperine, Alantolaktone, and Costunolide. Conclusion In order to succeed the above mentioned aim, we have achieved the following results: 3. The chromatographical method and methodology forthe qualitical and quantitative analyses of main compounds in the preparation Jonsh-6 were developed using HPLC. 4. The quantity of main components in the preparation Jonsh-6 were determined with HPLC and Safflomin-A 1.06 mg, piperine 0.195 mg, alantolaktone 1.12 mg and costunolide 0.925 mg are contained in 1.003 gm of the preparation.

Introduction: In 2007, ” National innovation Development Program in Mongolia” was adopted by 306th act of Mongolian government and indicated that its important to focus attention to research outcomes become real productions based on scientific knowledges, experiences, skilled personnel and possibility of laboratory and production. In Mongolian and Tibetan traditional medicine have been used many herbal and animal preparations has biological active compound with anti inflammatory effect for the treatment of wound healing and ulcer. One of them, Cacalia hastata L. is a medicinal plant, which is widely used for the treatment of wound healing, cholangitis and gastroduodenal ulcer in the Mongolian and Tibetan traditional medicine. It is appropriate to prepare film coated tablet for the treatment of gastric and duodenal ulcer, gel for the treatment of wound healing. Purpose: To prepare film coated tablet for the treatment of gastric and duodenal ulcer, gel for the treatment of wound healing from semi-solid extract of Cacalia hastata L. and determine their quality criteria. Material and methods: Herb of Cacalia hastata L. was collected as a raw material from Terelj in July 2009; from Batsumber soum, Tuv aimag province in July 2010, 2011. For determining of quality of semi-solid extract and new drug formulations were evaluated biological activity compounds such as alkaloid, carotenoid and flavonoid by spectrophotometric method. We prepared film coated tablet by wet granulation and film coating method and gel by dispersion method. Tests for significant differences between means were performed by one sample t-test and One way ANOVA using the software SPSS 16. Differences were considered significant at p<0.05. Results: We prepared tablet from semi-solid extract of Cacalia hastata L. For preparing the film coated tablet used mixture solution of 8 % gelatin and 6 % sodium carboxymethylcellulose as a binder, sodium carbonate as diluents. The tablet was coated 5% solution of hydroxypropylmethylcellulose with 10 % polyethyleneglycol as a film former used traditional coating pan. Film coated tablet was standardized by such criteria, as appearance (colour, smell), the average weight, amount of biologically active compound, hardness, disintegration, dissolution and bacterial contamination. We prepared Cacalia gel from semi-solid extract of Cacalia hastata L. using various excipients and determined quality criteria, developed technological scheme of preparing. Gel was standardized by such as criteria: appearance (color, smell), the amount of biologically active compound, pH, viscosity, spreadability, extrudability and bacterial contamination. Conclusions: 1. Developed technology of preparing 0.3 gram film coated tablet from semi-solid extract of Cacalia hastata L. and determined quality criteria. 2. Developed technology of gel from semi-solid extract of Cacalia hastata L. and standardized its quality.

Background: Class III malocclusion is considered to be one of the most difficult and complex orthodontic problems to treat. For patients whose orthodontic problems are so severe that neither growth modification nor camouflage offers solution, surgery to realign the jaws or reposition dentoalveolar segments is the only possible treatment option left. Aim: The treatment objectives were to: (1) level and align the dental arches; (2) obtain an ideal overbite and overjet, to establish correct anterior guidance; and (3) improve the facial profile. Case: Patient is present with skeletal Class III malocclusion, concave facial profile, facial proportion 0.96:1:1.04, loss of occlusion due to early molar teeth loss, molar and canine relationship were Class III, overbite 0 mm, overjet -1 mm, midline shifted into the 6 mm left side. Results: Excellent facial and occlusal results were achieved with this surgical-orthodontic management, post-treatment results showed a Class I relationship and ideal overjet and overbite. The facial profile became straight type. Conclusion This case report describes the treatment of a female with dental and skeletal class III relationships. Surgical- orthodontic treatment was the best option for achieving an acceptable occlusion and a good esthetic result in this case. An experienced multidisciplinary team approach ensures a satisfactory outcome.

In last years we have produced a combination species from medicinal plants which are used in traditional medicine and has tendentious the increasing of needs and production of plant preparations from natural resources. Although traditional medicine has being increased to be used last years, standardization of them is not sufficient. The standardization is important to ensure the safety, effectiveness and quality of traditional medicine. This research was made with purposes for determining of qualitative and quantitative analyses of biological active substances in the preparation such as Jonsh-5 is utilized to prevent osteoporosis, to accelerate bone ankylose in period of injure. The compositions of the preparation Jonsh-5 are Calcitum, Carduus crispus L. Inula helenium L.Terminalia chebula Retz, Forsutima suspense Thunb. Vahl.In order to succeed the above mentioned aim, we have achieved the following results: 1. The chromatographical method and methodology for the qualitative and quantitative analyses of main compounds in the preparation Jonsh-5 were developed using HPLC. 2. Quantitative analyses of main compounds of the compositions in the preparations were defined by HPLC method. 1.000gr of the preparation Jonsh-5 involves gallic acid 1.11 mg, alantolaktone 1.77 mg.