1.УРСГАЛ УСНЫ ЧИМЭЭГ ЭМЧИЛГЭЭНД АШИГЛАХ БОЛОМЖ
Dariimaa G ; Lkham-Edrene B ; Enkhjin B ; Nomin G ; Davaadulam E
Innovation 2017;11(2):103-107
In this study we aimed to check a hypothesis about water sound (WS) effect can
stimulate parasympathetic nervous system. A case-control study design was used. The
students in control group did not listen WS, whereas students in case groups had been
influenced under WSE by 3 different ways, including audio, video and shower. Data
base had been obtained by performance of stress test, measurements of systolic and
diastolic pressure, and counts of pulse. For statistical analysis, IBM SPSS 20.0 and Graphpad
prism 7.0 were used. Interestingly, 92% of total students had stress. There were no
differences between groups before WS effect. After WS effect, ANOVA test detected
differences in diastolic pressure (ANOVA, F=6.209, p=0.001), stress score (F=15.21,
p<0.001). Paired test was utilized to compare mean of values between before and post
WS measurements, finding SP (p=0.001), SS (p<0.001) categories. It showed an effective
WS influence. Chi-square test indicated that stress level of all students decreased significantly
(p<0.001). But there were no differences between 3 methods of water therapy. In
conclusion, WS has an effect of stimulation in immune system, useful for some diseases,
in which parasympathetic system decrease and sympathetic system increases.
2.Lead residue and health risk in some commonly consumed imported food products among Mongolian population
Enkhtungalag B ; Gereljargal B ; Tuvshinbayar B ; Oyundelger D ; Unurtsetseg CH ; Davaadulam B ; Tserenlkham B ; Khishigtogtokh D ; Sodnomtseren B ; Jargal E ; Batkhishig O
Mongolian Medical Sciences 2014;168(2):71-76
IntroductionThe imported food products are more than 60 percent of total food consumption of Mongolia. Thelead residue in food products causes chronic and acute poisoning to the human health when exceedsmaximum residues limits, and human exposure and significant public health problems in many partsof the world.GoalTo assess lead residues and health risk of some commonly consumed imported food productsamong Mongolian population.Objectives:1. To determine consumption of some imported food products of Mongolian population;2. To investigate lead residue in some commonly consumed imported food products;3. To assess potential health risk related lead residue.Materials and MethodsThe research used analytic study of cross-sectional study design. Randomly selected 1290 people’simports food consumption was analyzed by questionnaire and body weight measurements. Tooksamples from 145 import products, identified lead residue with Academy of Sciences Soil ResearchLaboratory`s, ASS (USA, 2002) equipment.Results60.7% of imported food samples were lead residues exceeded to Maximum Residues Limits, suchus mean lead residues in meat product were 1.55 mg/kg, in milk product 1.22 mg/kg, in cerealproducts 1.15 mg/kg, in vegetables 1.57 mg/kg, in fruit and fruit juice 1.03 mg/kg, in alcohols drink1.31 mg/kg, and in tea 1.93 mg/kg (p=0.001). Estimated Provisional Tolerable Weekly Intake (PTWI)of lead exposure for survey responses was 0.079mg/kg body weight.Conclusions:1. 60.7% of imported food samples were lead residues exceeded to Maximum Residues Limits,such us mean lead residues in meat product, milk products, fruits and vegetables.2. Imported vegetables (54.0%), cereal 8.4% products (15.5%), fruit and fruit juice (11.8%), andmilk products (8.4%) is main contributing to lead residues in imported food.3. Estimated Provisional Tolerable Weekly Intake (PTWI) of lead exposure for survey responseswas 0.079mg/kg body weight, which is 3.2 times higher than toxicological guidance (PTWI 0.025mg/kg per 1 kg human body weight) and the high health risk level.
3.ЭМНЭЛЗҮЙН УРЬДЧИЛАН ТООЦООЛОХ ДҮРМЭЭР НОЙР БУЛЧИРХАЙН ЦОЧМОГ ҮРЭВСЭЛТЭЙ ЭМЧЛҮҮЛЭГЧИЙН ТАВИЛАНГ ТОДОРХОЙЛОХ БОЛОМЖ
Dariimaa G ; Otgonjargal B ; Oyundari B ; Maral-Erdene D ; Tserennadmid Ts ; Davaadulam E
Innovation 2017;11(2):127-130
Нойр булчирхайн цочмог үрэвсэл, эмнэлзүйн урьдчилан тооцоолох дүрэм, Ranson –ийн шалгуур, APACHE II-ийн шалгуур
A clinical prediction rule is a type of medical research study in which researchers try to
identify the best combination of medical sign, symptoms, and other findings in predicting
the probability of a specific disease or outcome. More than 80% of all patients with
acute pancreatitis recover promptly without developing severe pancreatitis. The presence
of early organ failure (within 24 hours of admission), multiple-organ system failure,
and persistent or progressive (present beyond 48 hours after admission) organ failure are
associated with prolonged hospitalization, ICU admission, need for surgery, and death.
In high developed country, Ranson and APACHE II prognostic criteria are used in order
to evaluate patient´s situation and modified treatment tactics. That is give an idea us
to carry out retrospective study, by using patients´ documents, who hospitalized in National
central hospital in last year. As result, according to Ranson´s criteria 13 (31.7%) of
all patients had 0-2 score, which means mortality risk was 1.8%, 20 (48.8%) had 3-4 score
(mortality risk is 11%), 8 (19.5%) were estimated 5-6 score, having 33% of mortality risk.
Whereas, regarding to APACHE-II criteria 14 (34.2%) of total patients had score of 0-4,
showing 4% of mortality risk, 23 (56.1%) were scored 5-9, having 8% of risk, 3 (7.3%) were
scored 10-14, having 15% of risk, 1 (2.4%) had 15-19 score, having 24% of risk. Moreover,
we determined that incomplete laboratory test, meaning essential prognostic criteria
not used in Mongolia.
4.Identification of STS gene mutation in patient with hereditary ichthyosis
Purevdorj M ; Udval U ; Davaadulam E ; Purevbuyan B ; Sarangerel N ; Purevdorj I
Innovation 2020;14(1):28-31
Background:
The ichthyosis is a hereditary skin disease and inherited by autosomal dominant,
autosomal recessive and X recessive trait separately. The X-linked ichthyosis (XLI) is the most
frequent cutaneous disease and general incidence accounts for one in 2000-5000 male births.
Molecular pathogenesis of XLI is due to mutations, which are large deletion, missense, frame shift
and nonsense in STS gene. The vast majority of mutation frequency is a large deletion, which are
found in 85-90% of patients with XLI. An exon deletion of the STS can be detected by Polymerase
chain reaction with exon specific primers. An identification of STS gene mutation has various
importance such as 1) detection of mutation type; 2) for genetic counselling, 3) disease severity,
4) carrier detection.
Methods:
In the present study, pedigree analysis was used for type of inheritance, and Polymerase
chain reaction was used to detect a deletion in STS gene and normal control used. A deletion was
identified in case PCR bands were not visualized in agarose gels.
Results:
We included one patient, who had typical symptoms of XLI including dark, adherent
scales on skin. Mutation analysis of the STS gene showed that the patient had whole gene deletion
(del: Exon 1-10), which was demonstrated by the repeated amplification failure of exons. We used
a sample of healthy man as a wild type control, which showed normal amplification of STS gene’s
exons. Further, the current study will be focused on the screening of heterozygote large deletion
of Del: Exon1-10 of STS gene among patient’s female relatives.
Conclusion
An ichthyosis case enrolled in this study was inherited by X-recessive and we
identified whole exon deletion of STS gene in this patient.