1.The health impact assessment of mercury on artisanal and small scale miners and revealed chronic mercury intoxicated patients
Davaadorj R ; Baatartsol D ; Ouyntungalag S ; Suvd D ; Och G ; Uyanga G ; Khulan G ; Khulan B ; Govigere B ; Unursaikhan S
Mongolian Medical Sciences 2015;171(1):43-48
INTRODUCTION:In connection with request and financial assistance of Swiss Development Agency ‘’Mercury exposureand health impact assessment study among small scale miners in mercury free technology, wasconducted by researchers of Toxicology division of NCPH.GOAL:To determine mercury exposure level in biological samples of local small scale miners from mercury freetechnology introduced area. To reveal chronic mercury intoxicated patients,MATERIALS AND METHODS:Totally 147 artisanal miners from 33 cooperatives for small scale mining from Bayan-Îvoo soum ofBayankhongor, Bornuur sum of Tuv, Bayangol, Mandal and Tunkhel sum of Selenge province areparticipated in this study and the study was performed by cross sectional study methods during April toDecember, 2014.Over all 147 participants were in the first part of study, 60.5% out of 147 (89 participants) were in secondparts, and another 35.4% (52 people) were participated to the third parts of study. The participants wereundergone in to toxicological, dermatological and neurological examinations and the WHO guidance formercury exposure determination was followed in this study.RESULTS:On the results of all testing we revealed that there were 2 cases of chronic mercury intoxicated patientsfrom each Bayangol Bornuur soum, 2 from Mandal soum, and 3 from Bayanovoo soum.Overall 7 patientswere diagnosed as chronic mercury intoxicated and it comprised 4.7%of (n=147) all involved participants.We have observed that average height of total medical examination number was (2.9) in Bornuur soum.It indicated that there will have higher number of patients would exist in Bornuur soum than others.Ourstudy result has shown that neurological symptoms like tremor and imbalance were more diagnosedamong participants from Mandal and Bayngol soums. It implies that the health of the small scale minersfrom this soum more affected and needed to be investigating further.CONCLUSIONS:Mercury is still being used among artisanal gold miners even thoughit is still illegal. Further medicalevaluation and assistance needed to be taken for newly diagnosed 7 patients.
2.ВИРҮСТ ХЕПАТИТ, ЧИХРИЙН ШИЖИН ХАВСАРСАН ҮЕИЙН ЭЛЭГНИЙ БҮТЭЦ ҮЙЛ АЖИЛЛАГААНЫ ӨӨРЧЛӨЛТИЙГ M2BPGI БОЛОН ЭЛЭГНИЙ ЭДИЙН ШИНЖИЛГЭЭНИЙ ӨӨРЧЛӨЛТТЭЙ ХАРЬЦУУЛСАН ҮР ДҮН
Altantuya I ; Badamjav S ; Sainbileg S ; Uranbaigal E ; Otgonbayar R ; Bira N ; Davaadorj D
Innovation 2017;11(2):69-72
BACKGROUND. The 84.4 percent of newly diagnosed patients with diabetes have obesity
in Mongolia. Nowadays, prevalence of obesity has increased steadily in Mongolia.
Diabetic patients with viral hepatitis has high risk of having liver cirrhosis. Therefore,
screening of fatty liver and liver fibrosis in diabetic patients is more important. The main
diagnosing method of fatty liver and liver fibrosis is liver biopsy and histology but so far,
we are able to detect viral infection using viral marker and determine fibrosis stage of
NAFLD in patients who has diabetes mellitus type 2. Using noninvasive method determining
liver fibrosis involve many researches to reveal new biomarkers and technics to
find out liver fibrosis. Japanese researchers has found The Wisteria floribunda agglutinin-
positive human Mac-2-binding protein (WFA+-M2BP) was recently shown to be a
liver fibrosis glycobiomarker with a unique fibrosis-related glycoalteration.This biomarker
helps to determine liver fibrosis stage in fatty liver disease and viral hepatitis. There is
no research to reveal viral infection, fatty liver and liver fibrosis in diabetic patients in
Mongolia, so far. So it is necessary to study revealing viral infection, fatty liver disease
and to determine stages of fibrosis using WFA+-M2BP to screen liver fibrosis in diabetic
patients. OBJECTIVE. To identify viral infection, HCV/HBV in patients with diabetes and
to compare liver function and diabetes control for diabetic patients with liver disease.
METHODS. We collect data from 25thNovember, 2015 to October of 2016. We got permission
of research from the patients by handwriting signature who diagnosed Diabetes
mellitus in National University Hospital. Haemotology, biochemistry test, coagulogramm,
immunology test are evaluated in 415 patients in clinical laboratory of National university
hospital. By the objective, the diabetes patients with viral hepatitis will attend
to second step of research. We used HISCL 5000 apparatus of Sysmex Japan to do
immunology tests. Also we use SPSS 19.0 and EXCEL program. RESULT. There were 294
patients and by WHO classification of ages 20-29 aged patient (n=4), 30-39 aged(n=19),
40-49 aged(n=65), 50-59 aged(n=126), 60-70 aged(n=48), over 70 aged(n=14)or
53.24±9.43. 146 patients are male,148 patients are female.By BMI 29.9±1.14.By blood
test, thrombocytes counted 256.6±11.7;in coagulogramm the prothrombin time was
111.7±31.4; in biochemistry test total bilirubin 16.46±10.6; AP 364.7±192.3;AST 35.7±45.7;
ALT 42.8±45.5; GGT 86.53±123.4;albumin 42.06±23.95;total cholesterol 6.04±2.47;triglyceride
5.72±34.5;HbA1c 8.83±5.92; in immunology testsanti-HCV 29.37±18.87 (n=58); HBsAg
590.134±1013.7 (n=23); M2BP (COI) counted 2.24±2.19. CONCLUSION. There were 58
diabetic patients with C viral infection and 23 diabetic patients with B viral infection.
By WFA+-M2BP glycobiomarker, we found that diabetic patients with viral hepatitis has
more liver fibrosis.
3.Experiences and opportunities for efferent treatment of COVID-19 convalescent plasma
Yunden S ; Davaadorj R ; Ulziisaikhan T ; Och G ; Chimgee L
Mongolian Medical Sciences 2020;192(2):60-65
According to international medical organizations, the use of efferent therapy that COVID-19
convalescent plasma has shown some results.
Convalescent plasma that contains antibodies to severe acute respiratory syndrome coronavirus 2 or
SARS-CoV-2. This is being studied for administration to patients with COVID-19. Use of convalescent
plasma has been studied in outbreak of other respiratory infections, including the 2003 SARS-CoV-1,
the 2009-2010 H1N1 influenza virus, and the 2012 MERS-CoV.
Although promising, convalescent plasma has not yet been shown to be safety and efficacy of
COVID-19 convalescent plasma in clinical trials.
Plasmapheresis and membrane plasmapheresis of efferent therapy has been used in clinical
toxicology since 1995, in Mongolia.