1.Dihydroxy-isosteviol methyl ester of Pulsatilla nigricans extract reduces arsenic-induced DNA damage in testis cells of male mice: its toxicity, drug-DNA interaction and signaling cascades.
Samadder, Asmita ; Das, Jayeeta ; Das, Sreemanti ; Das, Durba ; De, Arnab ; Bhadra, Kakali ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2012;10(12):1433-42
To evaluate the ameliorative efficacy of dihydroxy-isosteviol methyl ester (DIME) of Pulsatilla nigricans extract in arsenic-induced DNA damage in testis cells of mice.
2.Potential of the homeopathic remedy, Arnica Montana 30C, to reduce DNA damage in Escherichia coli exposed to ultraviolet irradiation through up-regulation of nucleotide excision repair genes.
Das, Sreemanti ; Saha, Santu Kumar ; De, Arnab ; Das, Durba ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2012;10(3):337-46
To examine to what degree an ultra-highly diluted homeopathic remedy, Arnica Montana 30C (AM-30C), used in the treatment of shock and injury, can modulate the expression of nucleotide excision repair genes in Escherichia coli exposed to ultraviolet (UV) irradiation.
3.Rapid green synthesis of silver nanoparticles from silver nitrate by a homeopathic mother tincture Phytolacca Decandra.
Bhattacharyya, Soumya Sundar ; Das, Jayeeta ; Das, Sreemanti ; Samadder, Asmita ; Das, Durba ; De, Arnab ; Paul, Saili ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2012;10(5):546-54
To examine if a homeopathic mother tincture (Phytolacca Decandra) is capable of precipitating silver nanoparticles from silver nitrate (AgNO(3)) and to characterize the biosynthesized nanoparticles for evaluating their biological activities.
4.Potentized homeopathic drug Arsenicum Album 30C positively modulates protein biomarkers and gene expressions in Saccharomyces cerevisae exposed to arsenate.
Das, Durba ; De, Arnab ; Dutta, Suman ; Biswas, Raktim ; Boujedaini, Naoual ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2011;9(7):752-60
This study examines if homeopathic drug Arsenicum Album 30C (Ars Alb 30C) can elicit ameliorative responses in yeast (Saccharomyces cerevisiae) exposed to arsenate.
5.Analysis of the capability of ultra-highly diluted glucose to increase glucose uptake in arsenite-stressed bacteria Escherichia coli.
Khuda-Bukhsh, Anisur Rahman ; De, Arnab ; Das, Durba ; Dutta, Suman ; Boujedaini, Naoual
Journal of Integrative Medicine 2011;9(8):901-12
Whether ultra-highly diluted homeopathic remedies can affect living systems is questionable. Therefore, this study sees value in the analysis of whether homeopathically diluted glucose 30C has any effect on Escherichia coli exposed to arsenite stress.
6.Potentized homeopathic drug Arsenicum Album 30C inhibits intracellular reactive oxygen species generation and up-regulates expression of arsenic resistance gene in arsenine-exposed bacteria Escherichia coli.
De, Arnab ; Das, Durba ; Dutta, Suman ; Chakraborty, Debrup ; Boujedaini, Naoual ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2012;10(2):210-27
To examine if potentized homeopathic drug Arsenicum Album 30C (Ars Alb 30C) can reduce sodium arsenite-induced toxicity in Escherichia coli.
7.An initial report on the efficacy of a millesimal potency Arsenicum Album LM 0/3 in ameliorating arsenic toxicity in humans living in a high-risk arsenic village.
Khuda-Bukhsh, Anisur Rahman ; Banerjee, Antara ; Biswas, Surjyo Jyoti ; Karmakar, Susanta Roy ; Banerjee, Pathikrit ; Pathak, Surajit ; Guha, Bibhas ; Haque, Saiful ; Das, Debarsi ; De, Arnab ; Das, Durba ; Boujedaini, Naoual
Journal of Integrative Medicine 2011;9(6):596-604
Background: Millions of people are at risk of groundwater arsenic contamination, and there is no known remedy that can effectively remove the symptoms of prolonged arsenic poisoning. A potentized homeopathic drug, Arsenicum Album LM 0/3 (Ars Alb LM 0/3), is claimed in homeopathic literature to have the ability to treat symptoms similar to that of arsenic poisoning. Objective: This study examines whether Ars Alb LM 0/3 could provide some degree of amelioration for the victims living in an arsenic-affected village where no arsenic-free drinking water is available. Design, setting, participants and interventions: This study was carried out on volunteers living in an arsenic-affected village where no arsenic-free drinking water is available. Twenty-eight volunteers from the village of Dasdiya, in Haringhata block under Nadia District, West Bengal, India, an arsenic-contaminated village where wells contain 55 to 95 μg/L arsenic, were selected to undertake a double-blind and placebo-controlled trial. The subjects provided samples of blood and urine before and after 2 months of taking either "verum" or "placebo". Another 18 subjects living in an arsenic-free village, served as the negative controls. Main outcome measures: Samples of blood and urine from the subjects were assayed for arsenic content, according to various toxicity biomarkers and pathophysiological parameters. Results: Out of the original 28 subjects, only 14 subjects provided samples while the other 14 dropped out. There were elevated levels of arsenic in the blood and urine, alkaline and acid phosphatases, lipid peroxidation, and glutathione activities and increased blood glucose, triacylglycerol, cholesterol, and low-density lipoprotein cholesterol contents, whereas there were decreased levels of aspartate and alanine aminotransferases, gamma glutamyl transferase, glucose-6-phosphate dehydrogenase contents, high-density lipoprotein cholesterol and packed cell volume in the subjects. After 2 months of homeopathic remedy administration, the verum-fed subjects showed positive modulations within these parameters with slight lowering of matrix metalloproteinase activity as compared with the placebo group. Conclusion: Ars Alb LM 0/3 shows potential for use in high-risk arsenic villages as an interim treatment for amelioration of arsenic toxicity until more extensive medical treatment and facilities can be provided to the numerous victims of arsenic poisoning.