Objective To evaluate the implementing effects of the first round malaria control project supported by the Global Fund on malaria control in Sichuan Province so as to provide the evidence for intensifying the control strategy of malaria. Meth?ods Based on the requirements of the malaria project of Globe Fund the comprehensive malaria control measures including case identification health education and training for doctors were carried out. Results In 2007 the malaria incidence was 0.12/10 000 while it was 1.66/10 000 in 2002 with a reduction rate of 92.77%. The number of malaria endemic towns reduced from 13 to 2. The awareness rate of knowledge about malaria of the local residents rose from 26.86%to 79.83% χ2=403.00 P<0.01 with an increase rate of 197.21%. The awareness rate of knowledge about malaria of the students rose from 36.87%to 99.22% χ2=359.62 P<0.01 with an increase rate of 169.11%. Conclusions With the support of Globe Fund the trans?mission of malaria has been effectively controlled. The capacity of malaria control and the malaria control knowledge of the inhab?itants have been enhanced. The implementation of the project has significant effects on malaria control in Sichuan Province.