Objective To explore the gene expression of nuclear receptor corepressor(NCoR) in androgen independent prostate cancer(AIPC) and its clinical significance.Methods The expression of NCoR and androgen receptor(AR) was detected by two-stage immunohistochemical method in 15 cases with AIPC,20 cases with androgen dependent prostate cancer(ADPC) and 20 cases with benign prostatic hyperplasia(BPH) respectively.Results The rate of NCoR expression in AIPC,ADPC and BPH was 20%,80% and 95% respectively and the difference of NCoR expression between AIPC and ADPC,BPH was significant(P

ObjectiveTo investigate the clinical therapeutic effect and safety of solifenacin suceinate in the treatment of overactive bladder symptom after benign prostatic hyperplasia (BPH)operation.MethodsAmong 115 patients receiving BPH surgery,58 cases were given solifenacin at bedtime 4 d after surgery for 20 d (treatment group),and 57 cases were given anisodamine after surgery (control group).The urination of patients before and after pulling out catheter were observed,and urodynamic examination,international prostatic symptoms score (IPSS) and overactive bladder symptom score (OABSS) were used to evaluate urination status.ResultsIn treatment group,IPSS and OABSS decreased from 28.3 to 11.3 score and from (14.2±1.2) to (2.9±0.7) score before and after treatment,respectively (P＜0.01).In control group,IPSS and OABSS decreased from 27.3 to 11.8 score (P＜0.01) and from (14.2±1.6) to (11.3±1.1) score before and after treatment,respectively (P＞0.05).ConclusionsThe proper use of solifenacin after prostate operation may release bladder distress and facilitate rehabilitation in patients with overactive bladder symptom.