0.05). The expression of VEGF121 mRNA and VEGF165mRNA in BC with lymph node metastasis was significantly higher than that in BC without lymph node metastasis(P=0.033,0.004).Conclusions The expression of VEGF121 mRNA and VEGF165mRNA in BC tissues is upregulated, and VEGF121mRNA is likely to play the major role. A high level expression of VEGF mRNA in BC patient indicates the likelihood of lymph node metastasis.