Objective To evaluate the curative effect of normobaric oxygen therapy on fetal atrial premature contractions(PACs) with Doppler ultrasound. Methods Maternal normobaric oxygen therapy was performed in one hundred and seventy three fetus with PACs but without congenital heart disease diagnosed by Doppler echocardiography. Another 63 cases with isolated PACs receiving no therapy served as controls. Results (1) The average ratio of full recovery in the second course of treatment was 97.8 % in one hundred and seventy three fetus with PACs; (2) The valves′ regurgitation volume reduced or disappeared, the pericardial edema′s volume reduced or absorbed and the peripheral blood flow improved obviously (P

Objective To perform fetal karyotyping by percutaneous umbilical blood sampling guided by color Doppler ultrasonography in fetuses with congenital cardiac anomalies. Methods Fetal blood samples obtained by color Doppler ultrasound-guided cordocentesis in 56 fetuses with cardiac abnormalities detected by fetal echocardiography were taken for karyotyping.Fetuses were monitored post operation. Results The procedures were successfully performed in all cases and no procedure-related complications occurred.Six cases with abnormal karyotypes, 1 trisomy 21,2 trisomy 18,1 trisomy 13,1 trisomy AO and 1 cases 47XYY were identified and pre-operation ultrasonography detected multiple system anomalies besides cardiac anomalies in them. Conclusions Color Doppler ultrasonography facilitated percutaneous umbilical blood sampling by clear umbilical vein imaging and shortening the operation time.Abnormal karyotypes in fetuses with cardiac anomalies seemed to be related with multiple system anomalies.