Objective To explore the changes of pentraxin-3(PTX-3) in the normal left ventricular ejection fraction of patients with heart failure in patients of hypertention heart disease and discuss its clinical significance .Methods 156 outpatients or inpa-tients of department of Cardiovascular ,Geriatrics ,firstly diagnosed primary hypertension ,of Wuchang hospital in WuHan City were selected as research objects .the subjects were divided into two groups based on the results of echocardiography :simple primary hy-pertension(PH) group(42 cases)and hypertention heart disease(HHD) group(114 cases) ,the latter group were divided into with-out syptom of heart failure-NHF subgroup(34 cases) ,with normal left ventricular ejection fraction and syptom of heart failure-HF-NEF subgroup(36 cases)and with decreasing left ventricular ejection fraction and symptoms of heart failure-HFREF subgroup(44 cases) .To measure and analysis the level of PTX-3 ,high sensitivity c-reactive protein (hs-CRP) ,N-terminal pro-brain natriuretic peptide(NT-proBNP) in the blood plasm .Results Compared to HHD group ,the level of PTX3 ,hs-CRP ,NT-proBNP was lower (P<0 .01) .The level of PTX3 ,hs-CRP ,NT-proBNP was increased from NHF group ,HFNEF group to HFREF group ,significance differences were seen between each group .The level of PTX3 was positively correlated to hs-CRP(r=0 .573 ,P<0 .01) ,and was positively correlated to NT-proBNP(r=0 .452 ,P<0 .01) .Conclusion PTX3 increases with the progress of patients with primary hypertention heart disease ,It can be used as a biomarker of heart failure in the patients of hypertention heart disease with normal left ventricular ejetion fraction .