In a double blinded study which was conducted at 3 kindergartens of 3 communes of Thanh Ba district and Phu Tho district showed that the effectiveness of Vi-rEPA for typhoid fever in 2-5 year old children reached to 89% for 46 months. Vi-rEPA containing 25mg of Vi induced more than 8 fold rise of IgG anti-Vi in all vaccines. The dosage immunogenicity study of 5, 12.5 and 25mg of Vi-rEPA was injected 6 weeks apart and blood samples were taken before, 10 weeks and 1 year after the first injection. At 10 weeks, the antibody levels of children with 25 mg injections were higher than that of children with 12.5mg and 5mg injection, and all 3 groups had antibody levels declined 7 folds, but still remained significantly higher than before immunization. This study confirmed the safety and immunogenicity of Vi-rEPA
Vaccines ; Typhoid Fever ; child ; blood

A study was implemented to determine the frequency of Beijing family and atypical Beijing, two sub-groups of the Mycobacterium tuberculosis Beijing clade detected in Netherlands, Vietnam, and Hong Kong, and to assess the associations between these strains and patient characteristics. The typical Beijing family isolates were more prevalent than atypical Beijing strains and the former isolated from BCG-vaccinated individuals was also more frequently than the latter. The proportion of Beijing family strains was lowest among the patients aged over 75 years. Furthermore, atypical Beijing isolates were resistant to Isoniazide and several drugs, but less often resistant to Streptomycine than the Beijing family isolates
Drug Resistance ; Mycobacterium tuberculosis ; Vaccination ; Mycobacterium bovis

57 rifampicin-resistant tuberculosis strains isolated from Ha Noi Institute of Tuberculosis and Lung Diseases and Pham Ngoc Thach Tuberculosis Center of Ho Chi Minh City were involved in this study. The regimen included 2-month SHRZ and 4-month HR. All of these strains were resistant to rifampicin. It was found that rifampicin-resistant tuberculosis strains had mutations on rpoB gene. The mutation frequency of tuberculosis trains isolated from Ha Noi and Ho Chi Minh City was highest on 526 locus (55% and 41.6%, respectively) and 531 locus (30% and 33%, respectively).
Tuberculosis ; Mutation ; Rifampin

The cell-mediated immunity of extra-pulmonary tuberculosis patients was followed up during treatment with chemotherapy plus immunotherapy. The results showed that there was no significant difference between the group treated with chemotherapy and the group treated with chemotherapy plus immunotherapy
Tuberculosis ; drug therapy ; Immunotherapy

Population-based epidemiologic surveillance for bacterial meningitis in Hanoi from 2000 to 2002. The population under surveillance consists of children under 5 years of age, living in Hanoi urban districts. The results showed that bacterial meningitis represents an important cause of infant and childhood morbidity in Vietnam.
Meningitis, Bacterial ; epidemiology

A randomized investigation was conducted in 30 of total 80 private pharmacies registered enterprise at Nha Trang city from Mar to Apr 2004 to determine real situation of treatment diarrhea for children under advice of the pharmacies. Results: rate of pharmacies advising treatment for diarrhea by ORS are relatively low while ORS drug is used largely and effectively in treatment diarrhea. 87% pharmacies have provided incorrect counseling to their customers.
Diarrhea ; Child ; Pharmacies

Over 5 years we have conducted sentinel surveillance for rotavirus at six hospitals in Vietnam. More than 10,000 children less than 5 years old were admitted with diarrhea with fecal specimens screened for rotavirus. Overall, 55% were positive and there is variability in rates of rotavirus detection between sites (44%-62%). The older age children become infected, the higher percentage of rotavirus detected. the rotavirus strains appear to be the common type.
Diarrhea ; Rotavirus ; Child

The molecular characteristics of 44 H. influenzae strains were isolated from children with bacterial meningitis and 37 strains were isolated from children with acute respiratory infection were investigated. Of the 37 H. influenzae isolates from nasopharyngeal aspirates (NA), the serotype of 30 isolates were nontypeable, 4 were type b, 2 were type c and one was type a. Whereas those of 44 isolates from cerebrospinal fluid (CSF) were all type b. Twenty-six (70.3%) from NA and 23 strains from CSF were beta lactamase-producing, and the remaining strains were beta lactamase negative. PCR analysis to identify the resistant genes indicates 25 strains from NA and 21 strains from CSF had TEM-l-type-beta lactamase gene, 11 strains from NA and 22 strains from CSF lack all resistant genes, and each strain from NA and CSF had TEM-l-type beta lactamase gene and fts I gene with the same substitution as the low -betalactamase-negative ampicillin resistant (low-BLNAR) strain. No BLNAR strain was found. The MICs against 16 antibiotics between isolates from NA and CSF were similar except for penicillin G and ampicillin.
Haemophilus influenza ; Pediatrics ; Meningitis ; Bacterial Infections

From Jan. to Oct.2003, the rate of pathological bacteria H. influenzae and S. pneumoniae and viruses adeno, influenzae, entero, isolated from rhino-pharyngeal fluids of 198 pediatric under five years old of age patients with acute inflammation of respiratory tract treated at Hanoi’s St Paul Hospital was determined. The rate of isolated bacteria accounted for 41,9%, viruses 9,1%, and of both 2 bacterial and viral pathological agents in concomittence 4,55% of cases. Among them, isolated S. pneumoniae was the most- 35,8%, following by H.influenzae- 31,2%. 2 bacteria species were isolated in concomittance in 23 case samples. Among isolated viruses, adeno virus occupied 27%, influenzae 16% and entero virus 44%
Haemophilus influenzae ; Streptococcus pneumoniae ; viruses ; Respiratory System ; child ; Respiratory Tract Infections

The retrospective study reviewed 114 patients under 5 year old, hospitalized for intussusception (IS) over 3 years period (2000-2002) in General Hospital of Khanh Hoa province. The number of cases vary between 29 to 48 annually. Boy to girl ratio was 2:1. 64% of cases were children under 1 year old. The peak of IS was observed between 4 to 9 month old and had no difference in seasonal prevalence. Most common symptoms were abdominal pain, vomiting and abdominal mass. 88% of cases were diagnosed by ultrasound, 12% were confirmed by clinical diagnosis. Majority of cases was cured by radiological reduction. 5 cases must operated after failure of radiological reduction. No fatal case was reported
Intussusception ; child ; epidemiology ; diagnosis ; Therapeutics